Stage I or MGUS??

honoria · New User Joined: 27 Jun 2009 Posts: 3

New with questions. I have had MGUS since 1999, with an M-spike, sometimes 0.3, sometimes 0.6. Last exam showed 0.2.

The Freelite test shows increased Kappa to 3.18 mg/dL(norm 0.33-1.94), normal Lambda of 1.20 mg/dL(norm 0.57-2.63). Kappa/Lambda ratio showed 2.65 mg/dL (norm 0.26-1.65).

With the ratio being so out of range, does that increase to Stage I instead of MGUS? This ratio is the highest it's ever been, although, it's always above the norm.

The LDH was normal at 147 and IgG (800), IgA (234), IgM (162) were normal. I am told that I am IgA Kappa, and I don't know how to tell that, either. This is a very confusing disease!

I recently did a 24-hr urine, and the results showed small amount of protein, yet, on my serum albumin test, it was normal.

How worried should I be?

Thanks for any help.

Pat Killingsworth · Posted: Mon Jun 29, 2009 10:23 pm Post subject: Re: Stage I or MGUS??

Hello! Although I have authored a book on myeloma, Living with Multiple Myeloma and post daily on my blog

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I am not a physician. I would like to approach your situation from a different, positive perspective. Yes! I know it is difficult watching and waiting for your myeloma to appear. (and it will appear eventually) But look at it this way. Like many myeloma patients, by the time mine was diagnosed in April, 2007, I had suffered severe bone damage. My myeloma is under control. But the bone damage, although somewhat better, continues to be painful and limit my activity. So, the way I see it, you are in great shape! You can watch and monitor your myeloma, treating it before any damage becomes permanent. And, because the new drugs are working so well, your life expectancy should be measured in decades not years. Cool, right!? Good luck! Feel free to e-mail with questions anytime. Glad to help- Pat
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Pat Killingsworth

honoria · New User Joined: 27 Jun 2009 Posts: 3

Hi Pat,

Thank you for your very positive input of my condition. You are so up on myeloma to have written a book, which makes me feel even better when you state that the new drugs can help people measure their life expectancy in decades instead of years.

I also have bone loss, which is why the Dr. did the myeloma testing initially. FosamaxD has helped tremendously. I also had Aredia infusions some years back for 18 months, which also helped. So far, no jawbone injury!

I am happy to hear that your myeloma is under control, and I hope it stays that way for many, many years. I am hearing of some new drugs for this disease, so hopefully, they will all pan out.

I am also hearing, that one day sooner than we may think, myeloma may become chronic instead of terminal. There is hope.

I am reading your site which is very interesting and a learning process for me.

Thank you.

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