microbiological help

anb · New User Joined: 29 Jul 2009 Posts: 2

What pathogenic microbiological strains are apt to effectively eliminate non-pigmented nodular skin melanoma and its spreads at regional lymph nodes? (References are welcome.) The state of immune system and antibodies traffic are quite normal. The size of primary tumour is about 1.0x0.8 inch, 0.4 inch over skin, located 1.2 inch dorsolaterally against an ear bottom edge, lymph nodes are up to 1.2 inch size. Standard therapy (surgery, chemotherapy, and immunotherapy) is not set though good health because of last 50 years stable EKG and heart sounds "pathology" (the sequence of cured rheumatic myocarditis): «a hospice treatment if necessary» is suggested.

brainman · Posted: Wed Jul 29, 2009 10:08 am Post subject: Re: microbiological help

Hi anb. I do not think we have a member who is a pathologist. Nevertheless, one of our members might know the answer to your question.

Have you tried contacting the pathology lab are your own hospital? This would be my top suggestion.
Have you tried Google?
Have you tried going to the Medical Library of your local hospital?
Have you tried Yahoo!Answers? Have you tried any other forum? This would be my last option because of the potential for bad information.

I hope you find the answer. I am also sorry that you need to ask because, although you did not say, it probably means that you have or think you have a melanoma.
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2005 Recurrence this time said to be an Oligodendroglioma grade 3, same location.
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anb · New User Joined: 29 Jul 2009 Posts: 2

Thanks. I've found something at last, but it's too late - she died 2009/08/19...
Anyway I wonder: Why cancer is that popular now? Maybe some of germs that were humbly eating it are just slain or caged today?
"Virus therapy or virotherapy of cancer is an old theme. Almost every virus has been injected into humans in an attempt to treat cancer since early clinical observations of spontaneous cures after viral infections" (Alemany R. Cancer selective adenoviruses. Molecular Aspects of Medicine 2007; 28: 42–58 ).
Look at S pyrogenes action: "the tumour so extensively involved the deeper tissues of the neck that no attempt was made to remove it. A few days after the first attack of erysipelas had subsided, a second attack followed, lasting for a week. During these attacks of erysipelas, the tumour of the neck entirely disappeared and the patient left the hospital in good health. After great effort I finally succeeded in tracking the after history of this patient and found him alive and well, 7 years later" (Coley WB. Late results of the treatment of inoperable sarcoma by the mixed toxins of erysipelas and Bacillus prodigiosus. Am J Med Sci 1906; 131: 375–430).

Some more references:
Lynda K Hawkins, Nick R Lemoine, David Kirn. Oncolytic biotherapy: a novel therapeutic platform. THE LANCET Oncology 2002; 3: 17–26 (viruses – adenoviruses, herpesviruses, vaccinia virus, reovirus, poliovirus, vesicular stomatitis virus, newcastle disease virus, autonomous parvoviruses, some measles virus strains, dl1520, dl922/947; bacteria – Clostridium beijerinckii, Salmonella typhimurium).
Senior K. Bacterial protein causes cancer cells to self-destruct. THE LANCET Oncology 2002; 3: 712 (Pseudomonas aeruginosa).
John M Pawelek, K Brooks Low, David Bermudes. Bacteria as tumour-targeting vectors. THE LANCET Oncology 2003; 4: 548–56 (Salmonella strain YS1646).
Stefan J. Ries and Christian H. Brandts. Oncolytic viruses for the treatment of cancer: current strategies and clinical trials. Drug Discovery Today, Vol. 9, No. 17 September 2004, 759-768 (www.drugdiscoverytoday.com).
Ong HT, et al. Oncolytic measles virus targets high CD46 expression on multiple myeloma cells. Experimental Hematology 2006; 34: 713–720.
Thorne SH, Hwang TH, O•Gorman WE, et al. Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963. J Clin Invest 2007; 117: 335058.
Maura Reinblatt, MD, Richard H Pin, MD, Yuman Fong, MD. Herpes Viral Oncolysis: A Novel Cancer Therapy. J Am Coll Surg 2007; 205: No. 4S, October; S69-S75.
Stephen J. Russell and Kah-Whye Peng. Viruses as anticancer drugs. TRENDS in Pharmacological Sciences 2007; Vol.28 No.7, 326-333.
Markus J.V. Vaha-Koskela, Jari E. Heikkila, Ari E. Hinkkanen. Oncolytic viruses in cancer therapy. Cancer Letters 2007; 254: 178–216 (avian adenovirus, foamy virus, myxoma virus, yaba-like disease virus, echovirus type 1, bovine herpesvirus 4, Saimiri virus, feline panleukopenia virus, Sendai virus and the non-human coronaviruses).
Guo ZS, Thorne SH, Bartlett DL. Oncolytic virotherapy: molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses. Biochimica et Biophysica Acta – Reviews on Cancer 2008; 1785: 217–31.
Zeljko Bajzera, Thomas Carr, Kresimir Josic, Stephen J. Russell, David Dingli. Modeling of cancer virotherapy with recombinant measles viruses. Journal of Theoretical Biology 2008; 252: 109–122.
Alemany R. A smart move against cancer for vaccinia virus. THE LANCET Oncology 2008; 9: 507-508
Park B-H, Hwang T, Liu T-C, et al. Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial. THE LANCET Oncology 2008; 9: 533–42.
Pin-I Huang, Ju-Fang Chang, David H. Kirn and Ta-Chiang Liu. Targeted genetic and viral therapy for advanced head and neck cancers. Drug Discovery Today, Volume 14, Numbers 11/12, June 2009, 570-578.
Jacqueline Nuss Parker, David F. Bauer, James J. Cody, James M. Markert. Oncolytic Viral Therapy of Malignant Glioma. The Journal of the American Society for Experimental NeuroTherapeutics, Vol. 6, July 2009, 558–569.

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