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PLX4032 clinical trials What is this ?

 
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Twain
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Joined: 12 Oct 2009
Posts: 3
Location: Memphis
PostPosted: Mon Oct 12, 2009 11:55 am    Post subject: PLX4032 clinical trials Reply with quote
Hi folks - My 67 year old dad has just found out that his melanoma has returned and has now metastasized on his lungs and liver. His doctor estimated he has 3 to 6 months, even though right now he looks and feels pretty healthy. We are looking at clinical trials and are impressed with what we're reading about PLX4032 and we think we can get him in to one of the trials taking place. Does anyone have any comments on the drug and the trials taking place right now?

Thanks.
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jmp55
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Joined: 13 Oct 2009
Posts: 3
PostPosted: Tue Oct 13, 2009 8:57 pm    Post subject: Re: PLX4032 clinical trials Reply with quote
twain,

I suggest you visit the "Melanoma International Foundation Forum"...they could be very helpful in answering this question for you. You can google it to get the web site. I Hope this helps you.
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Twain
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Joined: 12 Oct 2009
Posts: 3
Location: Memphis
PostPosted: Tue Oct 13, 2009 9:29 pm    Post subject: Re: PLX4032 clinical trials Reply with quote
[quote="jmp55"]twain,

I suggest you visit the "Melanoma International Foundation Forum"...they could be very helpful in answering this question for you. You can google it to get the web site. I Hope this helps you.[/quote]

Many thanks. That's a helpful site.
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PL123
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Joined: 14 Oct 2009
Posts: 1
Location: San Francisco
PostPosted: Thu Oct 15, 2009 12:18 am    Post subject: Re: PLX4032 clinical trials Reply with quote
This compound produced very good clinical responses in Phase I trials (ASCO meeting 2009). It's reported to selectively respond to the frequently occuring B-RafV600E mutation, so it's important to check for that. It appears to be quite safe, but for a fraction of patients drug-induced formation of squamous cell carcinoma was observed (may be manageable). Best of luck for your dad.
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Twain
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Joined: 12 Oct 2009
Posts: 3
Location: Memphis
PostPosted: Thu Oct 15, 2009 7:35 am    Post subject: Re: PLX4032 clinical trials Reply with quote
[quote="PL123"]This compound produced very good clinical responses in Phase I trials (ASCO meeting 2009). It's reported to selectively respond to the frequently occuring B-RafV600E mutation, so it's important to check for that. It appears to be quite safe, but for a fraction of patients drug-induced formation of squamous cell carcinoma was observed (may be manageable). Best of luck for your dad.[/quote]

Thanks. This looks to be the most promising drug we've found in our research. Hope he can get in to a trial.
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