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Tamoxifen and endometrial cancer What is this ?

 
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ritavv
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PostPosted: Sun Nov 21, 2004 11:13 pm    Post subject: Tamoxifen and endometrial cancer Reply with quote
I have been on Tamoxifen for 3.5 years after having been diagnosed with stage 1 invasive breast cancer. At age 50, I was premenopausal and with my cancer 98% ER+, I went on Lupron for 18 months. Since then, my E2 and FSH levels indicate that I'm post-menopausal. This summer at 3yrs, I started spotting 4-5 days per week. An endometrial biopsy said there was no cancer. I should mention that I had an endometrial ablation in 1991 and therefore any procedure is complicated by that. They attempted a sonohysterogram but were only marginally successful because of the scar tissue. My gynocologist recommended that my oncologist switch me to one of the aromatase inhibitors instead of Tamoxifen which my oncologist agreed. I started arimidex this week.

However, I am not comfortable that there is no cancer. How accurate is an endometrial biopsy? Can I be sure that it is sampling the correct area? Wouldn't having my uterus removed solve all the problems... stop the bleeding and answer my questions. Am I overreacting because of previous cancer diagnosis? Any answers would be greatl appreciated.
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k1v1n
Guest
PostPosted: Sun Dec 05, 2004 6:25 pm    Post subject: Your endometrial biopsy Reply with quote
My wife had a negative endometrial biopsy the week before her hysterectomy. After removing her uterus they found endometrial stromal sarcoma (ESS). In her case, her endometrial biospy most definitely missed her cancer.

I believe that routine uterine biopsies will detect cancers in the endometrium but not in the deeper stromal cells.
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MissouriDJ
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Joined: 18 Mar 2005
Posts: 2
Location: Joplin Mo
PostPosted: Fri Mar 18, 2005 2:42 am    Post subject: Re: Tamoxifen and endometrial cancer Reply with quote
I had a hysteroscopy, a D&C, and a uterine biopsy done almost 2 weeks ago, and they found stage 1 endometrial cancer....in the lining only. I am worried about trying to take tamox to have a baby before I HAVE to have a hystorectomy....but that appears to have too many risks involved. I understand your anxiety about the tests not being conclusive enough...so yes...a hysto would more than likely be the only way of making sure.
_________________
Newly diagnosed stage 1 endometrial cancer, age 34...no children.
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