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AML with MDS What is this ?

 
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Bunny
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Joined: 08 Dec 2004
Posts: 1
PostPosted: Wed Dec 08, 2004 5:20 pm    Post subject: AML with MDS Reply with quote
My 67-year-old father was recently diagnosed with AML and went through the first round of chemo. We got the result of a post-chemo bone marrow biopsy yesterday, and it was reported to us that his AML is in remission, but he has myelodisplastic cells (and he hasn't been able to maintain normal levels of white or red blood cells on his own, but is well enough to be out of the hospital with transfusions and supportive care). We don't know what that means in terms of prognosis, except that it seems to be one of the worst scenarios. Information that we can find about MDS discusses the possibility of devleping AML. Does it mean that he had undiagnosed MDS that has already progressed to AML? How does that compare to AML with myelodisplastic cells? What is the prognosis? How long do most people survive?
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leo
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Joined: 23 Sep 2004
Posts: 1575
PostPosted: Thu Dec 09, 2004 6:10 pm    Post subject: Re: AML with MDS Reply with quote
Hello

Thanks for posting. Like you said, when someone with MDS evolves to AML it is pretty bad. It tends to be very aggressive. Nonetheless, after someone receives chemotherapy it is difficult to interpret the findings in the bone marrow. If it was thought by the doctors that his AML was one that progressed from MDS, it is likely that he had MDS for many years, and this is not easy to diagnose until it gets fairly advanced and the bone marrow starts to fail. It is impossible to tell you about a prognosis for our father, since I don't know what he has, because the are so many details such as cytogenetics and specific bone marrow features that modify his prognosis. You should talk to his hematologist about this. Regardless, the only established cure is an allogeneic bone marrow transplant, and unfortunately he is not a candidate for this given his age. But we never know who will do well. Maybe he will stay in remission for a long time, but we never know for sure.

best regards,
Leo
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