DRE Normal, PSA 30

Otago · Regular Joined: 20 Jan 2008 Posts: 28

I was just wondering if anyone knew whether taking ibuprofen in the weeks leading up to a retest PSA could in any way lead to a false negative?

Otherwise, might it not be beneficial to allow for the fact that a "itis" might not be caused by a bacteria but rather be non-bacterial prostatitis.
Seems I've read that the majority of prostatitis is non-bacterial. Thus antibiotics may not do the entire job at calming it down.
In that case it would seem allowing a anti-inflammatory to help reduce the "itis" might give a truer reading.

Any thoughts. I've seen mention of this on the site run by Don Cooley.

That site says the following...
"Take six weeks of Cipro (an antibiotic) and at the same time take NSAID's (Ibuprofen is fine if your system can tolerate them). If Ibuprofen is a problem use Celebrex or similar prescription drug."

This before accepting a high PSA test as valid.......leading to biopsy.

Otago

LizNDale · Posted: Tue Jul 01, 2008 2:26 pm Post subject: Re: DRE Normal, PSA 30

Brainman, Replicant,

You are both so right... Thanks for the perspective - I shared it with Dale right away, and even though he said he's not worried, I could tell it made him feel better.

Liz
_________________
My Mother - Stage IV NSCLC - Adenocarcinoma
Mets to Adrenal Glands and Brain
Diagnosed Thursday June 12th 2008
Died Sunday September 7th 2008

Her Story:
http://cancerforums.net/about9639.html
Her Statement of Faith Memorial:
http://cancerforums.net/viewtopic.php?t=10528

LizNDale · Posted: Fri Aug 22, 2008 1:33 pm Post subject: Re: DRE Normal, PSA 30

Back again!

We met with urologist today, Dale had his 4th PSA last week, and is still trending down, is now 8.3.

DRE still shows enlargement, "no big lumps or bumps".

Dr. recommends biopsy, but stressed he is pretty sure his high PSA is due to BPH and not cancer, but can't say definitively without the biopsy. We'll hear next week when it will be scheduled.

Ironic, his urologist is in the same bldng as my mom's onc. Maybe we can have his biopsy the same day as her next (and last!) chemo.

We both feel pretty positive about this. Sure, there's that little nagging "what if" hanging around the back of our minds, but our assumption is that the Drs vibes are the right ones.

So, I should know more in a couple weeks.

Regards to all,

Liz
_________________
My Mother - Stage IV NSCLC - Adenocarcinoma
Mets to Adrenal Glands and Brain
Diagnosed Thursday June 12th 2008
Died Sunday September 7th 2008

Her Story:
http://cancerforums.net/about9639.html
Her Statement of Faith Memorial:
http://cancerforums.net/viewtopic.php?t=10528

Replicant · Moderator Joined: 01 Nov 2006 Posts: 254

Glad to hear Dale's PSA is still headed in the right direction. I'll be interested in hearing the biopsy results, so please post! I'm betting it will be good news.
_________________
Replicant

Dx Feb 2006, PSA 9 @age 43
RRP Apr 2006 - Gleason 3+4, T3a, N0M0, pos margins
PSA 5/06 <0.1, 8/06 0.2, 12/06 0.6, 1/07 0.7.
Salvage radiation (IMRT) total dose 70.2 Gy, Jan-Mar 2007@ age 44
PSA 6/07 0.1, 9/07 <0.1, 12/07 <0.1, 4/08 <0.1, 11/08 <0.1
http://pcabefore50.blogspot.com

LizNDale · Posted: Fri Sep 12, 2008 1:16 pm Post subject: Re: DRE Normal, PSA 30

Dale's biopsy is in 2 hours.

My siblings and spouses and us are heading up to Lake Superior to spread some of mom's ashes (her lung cancer got the better of her and I'm sad beyond belief to report that she died this past Sunday).

This is a 3-4 hour car ride. We planned on going after his biopsy, but is it wise for us to do so? He would not have to drive.

Thanks for advice,

LiznDale
_________________
My Mother - Stage IV NSCLC - Adenocarcinoma
Mets to Adrenal Glands and Brain
Diagnosed Thursday June 12th 2008
Died Sunday September 7th 2008

Her Story:
http://cancerforums.net/about9639.html
Her Statement of Faith Memorial:
http://cancerforums.net/viewtopic.php?t=10528

Replicant · Moderator Joined: 01 Nov 2006 Posts: 254

He probably will be fine. I think I would have been okay on a trip like that after my biopsies. You might want to stop and let him move around a little bit. I'd just be ready to adapt to what he needs.

I'm sorry about your mom.

Best wishes.
_________________
Replicant

Dx Feb 2006, PSA 9 @age 43
RRP Apr 2006 - Gleason 3+4, T3a, N0M0, pos margins
PSA 5/06 <0.1, 8/06 0.2, 12/06 0.6, 1/07 0.7.
Salvage radiation (IMRT) total dose 70.2 Gy, Jan-Mar 2007@ age 44
PSA 6/07 0.1, 9/07 <0.1, 12/07 <0.1, 4/08 <0.1, 11/08 <0.1
http://pcabefore50.blogspot.com

LizNDale · Posted: Fri Sep 12, 2008 2:02 pm Post subject: Re: DRE Normal, PSA 30

Ok, thanks Replicant, for both the advice and your condolences.

Regards,

Liz
_________________
My Mother - Stage IV NSCLC - Adenocarcinoma
Mets to Adrenal Glands and Brain
Diagnosed Thursday June 12th 2008
Died Sunday September 7th 2008

Her Story:
http://cancerforums.net/about9639.html
Her Statement of Faith Memorial:
http://cancerforums.net/viewtopic.php?t=10528

LizNDale · Posted: Tue Sep 16, 2008 1:42 pm Post subject: Re: DRE Normal, PSA 30

Dale got good news from his biopsy, there is no cancer.

One quadrant does have pre-cancerous cells, and he will have another biopsy in 6 months.

What is generally done for pre-c cells, watchful waiting?

Is there anything Dale can do to reduce or change the cells?

Thanks,

Liz
_________________
My Mother - Stage IV NSCLC - Adenocarcinoma
Mets to Adrenal Glands and Brain
Diagnosed Thursday June 12th 2008
Died Sunday September 7th 2008

Her Story:
http://cancerforums.net/about9639.html
Her Statement of Faith Memorial:
http://cancerforums.net/viewtopic.php?t=10528

Replicant · Moderator Joined: 01 Nov 2006 Posts: 254

If it was high grade PIN, there's a strong chance (30% or higher) that prostate cancer will be found in a subsequent biopsy. Google "high grade PIN" for more (or low grade, if that's what it was.) I'm traveling and my Internet access is awful, or I'd look some of this up for you.
There have been efforts to see if drugs can prevent PIN from turning into PCa. Not sure about how successful (my uro unsuccessfully tried Avodart after finding high grade PIN in me).
Wish I could help more--I'll check back when I get home.
Good luck!
_________________
Replicant

Dx Feb 2006, PSA 9 @age 43
RRP Apr 2006 - Gleason 3+4, T3a, N0M0, pos margins
PSA 5/06 <0.1, 8/06 0.2, 12/06 0.6, 1/07 0.7.
Salvage radiation (IMRT) total dose 70.2 Gy, Jan-Mar 2007@ age 44
PSA 6/07 0.1, 9/07 <0.1, 12/07 <0.1, 4/08 <0.1, 11/08 <0.1
http://pcabefore50.blogspot.com

LizNDale · Posted: Tue Sep 16, 2008 4:51 pm Post subject: Re: DRE Normal, PSA 30

Thanks replicant,

Not sure if this is hgpin (or low) or asap, Dale has a call into the dr to find out.

I spent quite a bit of time on google, at cancer.org I found stat of 20% if hgpin, 40-50% if asap. They also say that half of all men have PIN by the time they reach 50.

They also talk about PIA. We'll get more info from dr.

We feel pretty good about this, if the PIN does turn to PCa, then at least it's been caught early!

I've read that there has been some possible success with lycopene, best source processed tomato, as the heating makes the lycopene more easily absorbed by the body, especially if heated with oil. So i think we'll have spaghetti once a week from now on!

Liz
_________________
My Mother - Stage IV NSCLC - Adenocarcinoma
Mets to Adrenal Glands and Brain
Diagnosed Thursday June 12th 2008
Died Sunday September 7th 2008

Her Story:
http://cancerforums.net/about9639.html
Her Statement of Faith Memorial:
http://cancerforums.net/viewtopic.php?t=10528

LizNDale · Posted: Wed Sep 17, 2008 2:47 pm Post subject: Re: DRE Normal, PSA 30

It is HGPIN. Stats are all over the place, older studies showing the higher rate of morph to PCa, new studies showing about 22%. Newer studies also show that the greater number of cores w/PIN, the greater % of PCa dx in subsequent biopsies. Dale had only 1 core with HGPIN. (Dale used the word quadrant, so perhaps we need clairification.)

So Replicant, is this how your battle started, with a HGPIN finding at biopsy?

Liz
_________________
My Mother - Stage IV NSCLC - Adenocarcinoma
Mets to Adrenal Glands and Brain
Diagnosed Thursday June 12th 2008
Died Sunday September 7th 2008

Her Story:
http://cancerforums.net/about9639.html
Her Statement of Faith Memorial:
http://cancerforums.net/viewtopic.php?t=10528

Replicant · Moderator Joined: 01 Nov 2006 Posts: 254

Liz n Dale,

Well, it sounds like you're going to stay on top of it--sounds like Dale has a good uro.

Mine actually started with me getting up a lot a night to use the bathroom. Now, if at that time I would have actually been afflicted with PCa and that was causing my problem, I would have been in deep trouble, because PCa that is causing symptoms is often advanced. As it turned out, the symptom was probably BPH-related.

My PSA was high for my age (4 something at age 43) and I got referred to a urologist. On first biopsy, everything was fine--some signs of calcification maybe. So I think at that point we tried antibiotics and high dose Motrin to see if it would come down. I think it did, but not much. So it was time for biopsy 2. At that point he found high grade PIN, but no cancer, so we tried a long course of Avodart. Avodart dropped my PSA in half to 2 something--that's a well known fact that Avodart does that, so to get your real PSA you multiply by 2.

The Avodart relieved my mild BPH, which had been keeping me awake at night having to urinate.

I stayed at that relatively low PSA for a year or so, and then suddenly my PSA doubled--while still on Avodart. That alarmed my urologist, and when he did a DRE, he found a bump. Or lump. Whatever.

So it was off for biopsy #3. I had been kind of a whiner about the first two, so the uro did this one in the hospital under general anesthetic. Cost me $700 but boy was that an easy procedure!

And that's when they found the cancer.

The rest is pretty well outlined in my blog.

Good luck and best wishes for Dale's health!
_________________
Replicant

Dx Feb 2006, PSA 9 @age 43
RRP Apr 2006 - Gleason 3+4, T3a, N0M0, pos margins
PSA 5/06 <0.1, 8/06 0.2, 12/06 0.6, 1/07 0.7.
Salvage radiation (IMRT) total dose 70.2 Gy, Jan-Mar 2007@ age 44
PSA 6/07 0.1, 9/07 <0.1, 12/07 <0.1, 4/08 <0.1, 11/08 <0.1
http://pcabefore50.blogspot.com

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