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Researchers find BRCA1 tumor suppression nullified by cycli What is this ?

 
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leo
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PostPosted: Mon Aug 08, 2005 8:06 am    Post subject: Researchers find BRCA1 tumor suppression nullified by cycli Reply with quote
Scientists have discovered that a protein called cyclin D1, grossly overproduced in about half of all cases of breast cancer, can also disrupt BRCA1's normal role as a cancer inhibitor. Because cyclin D1 binds to the same estrogen receptor as does BRCA1, when the cell is flooded with cyclin D1, BRCA1 is unable to activate a pathway that stops cancer development.Study results reaffirm cyclin D1 as a candidate target for molecular therapeutic control of breast tumor development.

[url=http://www.eurekalert.org/pub_releases/2005-08/gumc-rfb080505.php]Read more...[/url]
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