Oligodendroma - Loss of heterozygosity 1p/19q

Derek

G'day all from Oz,
I was just curious as to how many (percentage) have been tested for the above-mentioned genetic test and have come back positive to 1p/19q deletions for this tumour.
My wife and I have only just been notified to go ahead with the chromosome test.
I have read that there is a better long term prognosis (response to chemo and radiotherapy) if these deletions are present.
I will relay our results when we get them back from pathology. (Fluorescent in situ hybridizaion) test.
Thank-you all for your previous replies, and I pray that everyone affected by this disease can be cured.
Derek

rlee · Site Admin Joined: 15 Jan 2006 Posts: 245

Derek,
Yes, what you said seems to be true, at the preliminary evidence show this. I did a quick pubmed search and found several articles supporting your statement that 1p/11q deletions are predictive with response.

Here is a link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16954518&itool=iconabstr&query_hl=1&itool=pubmed_docsum

Remember to take everything in context, it's predictive but not absolute. It's kind of like statistics on survival. There will always be a subgroup that responds even when the tests say they won't. Good luck.
_________________
RLee, MD

Any information provided is NOT intended to provide specific medical advice to users but rather to provide users with information to help them better understand their health condition and related care. All readers are strongly encouraged to consult with a qualified physician for answers to their personal medical questions.

brainman

Hi Derek,

I was tested for this genetic mutation... however, I do not remember the results... it has been a long time (anything over 1 year is a long time Laughing

). In any event, I took two cycles of chemotherapy (CCNU), then surgery, and then radiation therapy but have not had any additional chemotherapy. My last treatment was March 2006 and I am still here Very Happy

.
_________________
Jim
Site Administrator and long-term cancer survivor
1992 Astrocytoma grade 2, left motor strip
2005 Recurrence this time said to be an Oligodendoglioma grade 3, same location.
My Story Part 1: http://cancerforums.net/viewtopic.php?p=7350
My Story Part 2: http://cancerforums.net/viewtopic.php?t=8029
Blog http://jimhawkinsport.blogspot.com/

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