Oligodendroglioma - Loss of alleles 1p/19q, cause and effect

Derek

Hello again,
First of all, great news for my wife, she is positive for 1p and 19q deletions on these chromosome arms.
Next, although this seems to be a "genetic signature" for the majority of oligodendrogliomas, I was curious as to whether anyone knows whether these abnormalities are acquired at some stage during adult life, or you are born with them.
In other words if you did a chromosome test say 10 years before the onset of the oligodendroma, would you get the same result?
Is there an increased likelihood of passing this down to the next generation.
Next, whether aquired or innate, as these deletions predispose one to oligo disease, is it possible to get another one totally unrelated to the first one. ie at a different location, and NOT a recurrence of the original one?
I ask a lot of questions I know.
Derek

brainman

Derek, ask away Laughing

. The only way we learn is by first asking questions. I know that there have been studies on familial connections with gliomas. However, I do not think any of them have ever been conclusive. Personally, based on the fact that my mother had a GBM and I had an Oligodendrogioma, I wonder about that too... worried that my children or grandchildren might someday develop a glioma. However, it is really too early to tell. I guess they could have a blood test to determine if that particular mutation of the alleles 1p/19q is present, but then what? Live a life in fear? Since, currently, there is nothing anyone can do to prevent a glioma, I say it is better (in this case) not to know. If you have read very many of my posts, you know that my stand of this particular issue is totally opposite of my usual attitude. I want to know everything! But in this case, I have to ask if it would not actually be better not to know... at least until latter in life. I guess earlier detection might help. Anyhow, this is just my humble opinion as one who has had to live with the threat of a recurrence for 15 years.

A second primary of any glioma is very rare. Glioma's themselves are rather rare with only about 17,000 patient being diagnosed each year in the USA: http://www.mayoclinic.org/glioma/ . Most common is a recurrence in the same location as the original.
_________________
Jim
Site Administrator and long-term cancer survivor
1992 Astrocytoma grade 2, left motor strip
2005 Recurrence this time said to be an Oligodendoglioma grade 3, same location.
My Story Part 1: http://cancerforums.net/viewtopic.php?p=7350
My Story Part 2: http://cancerforums.net/viewtopic.php?t=8029
Blog http://jimhawkinsport.blogspot.com/

Trigggl · Regular Joined: 20 Dec 2004 Posts: 25 Location: LR, Ar

From my experience, I wish I had known about my tumor before the seizures happened. I still would have had to go through the chemo, but the effects of the seizures were severe. Hindsight is 20/20, but I did notice some strange things with my vision before I had the seizures. I noticed one eye would be off vertically if I relaxed them. Of course, my tumor was in the frontal lobe. I mentioned it to a coworker and she suggested an MRI. I wish I'd listened to her.

I wouldn't worry about a tumor unless you experience some new really weird symptom.

As for me, my life is pretty normal now. I'm a glioma survivor.
_________________
Greg --> 3 years and counting
http://www.geocities.com/trigggl/
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