Hypoxia and cancer: breathing patterns and oxygenation

artour · New User Joined: 31 May 2008 Posts: 4

Dear friends,

Hypoxia is the fundamental cause of cancer (see titles below). Do you know how to breathe in order to prevent and cure cancer? In other words, which breathing pattern provides maximum oxygenation of tissues?

Dr. Artour Rakhimov

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Harris AL, Hypoxia: a key regulatory factor in tumour growth, National Review in Cancer 2002 January; 2(1): p. 38-47.

Ryan H, Lo J, Johnson RS, The hypoxia inducible factor-1 gene is required for embryogenesis and solid tumor formation, EMBO Journal 1998, 17: p. 3005-3015.

Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM, Johnson RS, Hypoxia-inducible factor-1 is a positive factor in solid tumor growth, Cancer Res, August 1, 2000; 60(15): p. 4010 - 4015.

Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR, Dewhirst MW, Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma, Cancer Reserach 1996, 56: p. 941-943.

Chaplin DJ, Durand RE, Olive PL, Acute hypoxia in tumors: implications for modifiers of radiation effects, International Journal of Radiation, Oncololgy, Biolpgy, Physics 1986 August; 12( Cool

: p. 1279-1282.

Denko NC, Fontana LA, Hudson KM, Sutphin PD, Raychaudhuri S, Altman R, Giaccia AJ, Investigating hypoxic tumor physiology through gene expression patterns, Oncogene 2003 September 1; 22(37): p. 5907-5914.

Evans SM & Koch CJ, Prognostic significance of tumor oxygenation in humans, Cancer Letters 2003 May 30; 195(1): p. 1-16.

Kunz M & Ibrahim SM, Molecular responses to hypoxia in tumor cells, Molecular Cancer 2003; 2: p. 23-31.

Rockwell S, Oxygen delivery: implications for the biology and therapy of solid tumors, Oncology Research 1997; 9(6-7): p. 383-390.

Schmaltz C, Hardenbergh PH, Wells A, Fisher DE, Regulation of proliferation-survival decisions during tumor cell hypoxia, Molecular and Cellular Biology 1998 May, 18(5): p. 2845-2854.

Vee Smith · Moderator Joined: 12 Feb 2006 Posts: 790 Location: UK

It is not [b]the[/b] fundamental cause. It is a contributory cause.

In

artour

Please be careful in the Information you post and advise. This post is very close to "selling". For a very first post to be all about

:QUOTE: Hypoxia is the fundamental cause of cancer. Not only does it worry me why you'd post this as a first post- but why would you.

Please read our policies. Be careful or what you post, and how you post it. We like all sorts of new and improved information. If correct and not "selling the information or sites etc."

I have deleted your link- due to our policies.

Thankyou- admin
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ChemoMan

Oh dear sounds like spam to me. Sad

I checked out 'Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma' and its about exploring" the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. " AT A CELLULAR LEVEL ! nothing to do with breathing. Please re read all the articles and if necessary get a colleague to explain them to you.

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artour · New User Joined: 31 May 2008 Posts: 4

Hi, ChemoMan

You wrote:
AT A CELLULAR LEVEL ! nothing to do with breathing

Well, my friend, if you take 100 fast and deep breaths in succession and through the mouth, I will pass out due to ... hypoxia in your brain at a cellualr level. Hence, this is exactly what I am talking about. Cancer patients are hyperventilators and because of this they suffer from cellular hypoxia.

Regards, Artour

ChemoMan

Hi Artour

Hypoxia is lack of oxygen. You seem to be implying the opposite !

Cheers
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Diffuse Large B cell Lymphoma
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Finished six cycles of R chop 21 26th May 2008
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Remission confirmed 1st October 2008
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artour · New User Joined: 31 May 2008 Posts: 4

Hi,

No. I am talking about tissue hypoxia, not low O2 in the lungs or blood. This is where oxygen is required and where it is low in all sick people due to .... overbreathing. This is the paradox of breathing: sick people breathe 2-4 times more than the medicla norm, but tissue oxygenation is low.

Regards, Artour

brainman

I think we can all agree that hypoxia can be caused be caused by rapid breathing otherwise why would a person who is hyperventilating need to breath into a bag? (Breathing too rapidly does not give the body time to go through the normal O2/CO2 exchange process). The real question is does hypoxia have any thing to do with cancer? Probably very little so, please, let us move on.
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artour · New User Joined: 31 May 2008 Posts: 4

HI, Jim,

(Breathing too rapidly does not give the body time to go through the normal O2/CO2 exchange process).

Gas exchange in the lungs take place in a fraction of a second. During physical exercise we can breathe very rapidly, up to 50 times per minute with 3 l of air per breath, and there are no problems with gas exchange.

Deep breathing washes out CO2 and this results in 2 physiological effects: vasoconstriction and the suppressed Bohr effect. Both causes tissue hypoxia. There are 2 other phenomena: 99% people believe that big and deep breathing is good for health, but there are thousands of medical studies about negative effects of hyperventilation. Sick people have heavy breathing, cancer included, but oxygenation and stress-free breath holding time is short. Breathing of healthy people is invisible and inaudible, but breath holding time is long.

Dr. Otto Warburg, the Nobel Laureate, in his article “The Prime Cause and Prevention of Cancer” (1966) wrote, “Cancer, above all other diseases, has countless secondary causes. Almost anything can cause cancer. But, even for cancer, there is only one prime cause. The prime cause of cancer is the replacement of the respiration of oxygen (oxidation of sugar) in normal body cells by fermentation of sugar… In every case, during the cancer development, the oxygen respiration always falls, fermentation appears, and the highly differentiated cells are transformed into fermenting anaerobes, which have lost all their body functions and retain only the now useless property of growth and replication.“
Many websites has this paper, e.g.:
{link deleted by admin}

But there are other studies by Russian doctors who found that normalization of breathing and oxygenation assists disappearance of tumours (stages 1 and 2).

The breathing does not need to be fast for hyperventilation to exist. Even slow (15-20 times per min) but deep bretahing (1 l per breath) at rest will cause hypocapnia and hypoxia.

Best regards, Artour Rakhimov.

brainman

Since you opted NOT to move on, I have locked the topic. Please, do not start a new one on this topic.
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Site Administrator and long-term cancer survivor
1992 Astrocytoma grade 2, left motor strip
2005 Recurrence this time said to be an Oligodendoglioma grade 3, same location.
My Story Part 1: http://cancerforums.net/viewtopic.php?p=7350
My Story Part 2: http://cancerforums.net/viewtopic.php?t=8029
Blog http://jimhawkinsport.blogspot.com/

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