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Question on Bladder Cancer? What is this ?

 
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sanjis
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Joined: 12 Oct 2007
Posts: 29
PostPosted: Tue Feb 12, 2008 11:13 am    Post subject: Question on Bladder Cancer? Reply with quote
My husband had the DaVinci Prostatectomy done Dec. 13th. The margins came back negative. His PSA level has returned to undetectible. But they found Adencarcinoma at the base of the bladder and at the Apex.
If it starts to spread will PSA levels go back up?

Right now it is just wait and see.

Last edited by sanjis on Tue Feb 12, 2008 1:46 pm; edited 1 time in total
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Replicant
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Joined: 01 Nov 2006
Posts: 167
PostPosted: Tue Feb 12, 2008 12:55 pm    Post subject: prostate vs. bladder cancer Reply with quote
Yes, if your husband were to have a recurrence, PSA should start climbing. After surgery, PSA is a MUCH more useful screening tool.

If prostate cancer spreads elsewhere, it is still prostate cancer. Under a microscope, the cells would look like deformed prostate cells, and they produce PSA. So it wouldn't be bladder cancer per se, it would be prostate cancer in the bladder.

A study at Indiana University ( http://www3.interscience.wiley.com/cgi-bin/abstract/109594246/ABSTRACT?CRETRY=1&SRETRY=0 ) showed that bladder neck involvement is a risk factor for PSA recurrence, although it's not as bad as if there were seminal vesicles involved ( http://www.oncolink.com/resources/article.cfm?c=3&s=8&ss=23&id=756&month=11&year=2000 ) leading some researchers to question whether or not bladder neck involvement really puts the patient into a T4 stage or whether it's really more appropriate to be classified T3.

You will indeed want to monitor PSA closely, and be prepared to consult with a radiation oncologist and medical oncologist if you see a rise.

Don't take this as medical advice, of course. I'm just a patient with some research skills.
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Dx Feb 2006, PSA 9 @age 43
RRP Apr 2006 - Gleason 3+4, T3a, N0M0, pos margins
PSA 5/06 <0.1, 8/06 0.2, 12/06 0.6, 1/07 0.7.
Salvage radiation (IMRT) total dose 70.2 Gy, Jan-Mar 2007@ age 44
PSA 6/07 0.1, 9/07 <0.1, 12/07 <0.1, 4/08 <0.1
http://pcabefore50.blogspot.com
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