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Thread: Does Lupron wear off?

  1. #1
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    Does Lupron wear off?

    My PSA was at 158 prior to Lupron and then went to 2.14. I received the 30mg shot on Dec 11, 09. It has been right at 3 months and I am due for a shot now. My PSA is at 3.20. Does Lupron wear off towards the end of the 3 month cycle and the PSA goes back down again? My AlkPhos went from 69 to 89 in the last week also. Am I already looking at Hormone Refractory? Any experience with this is appreciated.
    Age 39 DRE 11/12/09, biopsy 11/23/09-positive in 12 of 13 cores, GS 9, PSA 158, CT Scan - bladder, lymph nodes, Bone Scan- Hips, Pelvis, Ribs, Spine, Shoulder Blades, Sternum. PSA after Lupron 1/6/10 of 19.5, 2/5/10 2.7 N2M1c

  2. #2
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    thetackle, - I have no personal experience with Lupron. Of course the effects of Lupron eventually wear off, hence the need for repeated treatments. However, whether that is the cause of your current elevating PSA is highly questionable.

    You are apparently a particularly young man with a highly aggressive form of Prostate Cancer. You are the exception to the rule and much of what is "normal" in PCa treatment is, quite possibly, not going to apply in your specific case. If you have not already, I would suggest that you investigate the currently available Clinical Studies, for which you may be eligible, if there are any.

    I would also suggest that you, or your attending Physician, contact the Oncology Department at the nearest University Medical Center, to see if they would have any special interest in your case. There would likely be benefit in a team approach to your care and this is likely to be more readily available at such an institution, particularly if they have research facilities.

    If nothing is available there, I would investigate any possible interest from the NCCN institutions nearest you. All of these possibilities are "long-shots", but if I was you, I would make the effort.

    I am NOT a physician but, if you wish to talk, I will be happy to provide my phone number. You can E-mail me in Scottsdale, AZ. at: - John@newPCa.org (aka) az4peaks

  3. #3
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    Well, Lupron doesn't really wear off that quickly. My PSA is rising and at 9.9. I have been on Lupron for about 6 months and became refractory after about 3. My oncologist put me back on Casodex (didn't help) and has now taken me off of Casodex to see if the withdrawal confuses the cancer and drops the PSA. Bone mets increased, but tumor mass in prostate and bladder appear to have decreased. I am working with the Kelley Protocol featuring Pancreatic Enzymes, but have no data on it's success yet. I will keep you all posted.

    Always in my prayers,
    thetackle
    Age 39 DRE 11/12/09, biopsy 11/23/09-positive in 12 of 13 cores, GS 9, PSA 158, CT Scan - bladder, lymph nodes, Bone Scan- Hips, Pelvis, Ribs, Spine, Shoulder Blades, Sternum. PSA after Lupron 1/6/10 of 19.5, 2/5/10 2.7 N2M1c

  4. #4
    The Prostate Cancer Research Institute website has a free DVD set by Dr Scholz and Dr Lam on HRPC that is very informative. There are also numerous articles on the website relating to HRPC. Also PAACT has a lot of information on HRPC.
    Good luck and learn as much as you can.
    JohnT
    psa at diagnosis 40 in nov-08
    gleason 6 and 7
    Treatment choice seeds and IMRT

  5. #5

    thetackle

    Good to hear from you again. Thanks for keeping us posted. All the best wishes your way.
    R.
    Replicant

    Dx Feb 2006, PSA 9 @age 43
    RRP Apr 2006 - Gleason 3+4, T2c, NXMX, pos margins
    PSA 5/06 <0.1, 8/06 0.2, 12/06 0.6, 1/07 0.7.
    Salvage radiation (IMRT) total dose 70.2 Gy, Jan-Mar 2007@ age 44
    PSA 6/07 0.1, 9/07 (and thereafter) <0.1
    http://pcabefore50.blogspot.com

  6. #6
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    Suggest if you cannot hire the best specialists-onco docs

    You might wish to look heavily at drugs that can work against HRPCa:
    like these- DES, estradiol patches, emcyt, ketoconazole and there are others. Join the group at www.hrpca.org (checkout yahoo groups for such) Howard Hansen is the lead mentor with alot of experience in this arena and other people whom are communicating globally with similar issues and what they have done or are doing or plan on doing.

    If you can hire Dr. Scholz, Strum, Volgelzang, Myers and these types it would be probably worthwhile even if you cannot win the war, you may win some battles. I had some bad stats, although not as high as your psa level and with total urinary blockage and 12/12 pos. biopsies (all 75-95% PCa) and gleasons 7,8,9's, scans appeared clear. Been over 8 yrs. thus far and in good health thus far. Dropped ADT3 drugs back around 2005 and used nothing for 1 year, then intermittent DES for the last 4-5 yrs. now with good results and basically no side effects. There are 18 variant types of PCa and 3 types of ploidity DNA analysis on each of those, as an idiot layperson I would say you may have a variant type that can easily go undected by pathologists. Some do not respond well to hormone therapies. Look into everything asap...is my advice. You may wish to reflect upon what is glorious and everlasting.

  7. #7
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    Thanks guys! I think we are looking at ketoconazole next. I have an appointment on June 15th to discuss. DES has also been discussed as another option available before or after keto. Provenge of course is there at some point, too. Have not done any chemo yet. Not sure what I think about that one. We have been researching tirelessly still about any and all options. I am not sure if I have confidence in my oncologist. She is very smart, just very much by the book with no real creative or independent ideas. She does not specialize in Prostate Cancer, just Cancer. Any more ideas on top notch PCa specialists would be greatly appreciated.
    Brian.
    Age 39 DRE 11/12/09, biopsy 11/23/09-positive in 12 of 13 cores, GS 9, PSA 158, CT Scan - bladder, lymph nodes, Bone Scan- Hips, Pelvis, Ribs, Spine, Shoulder Blades, Sternum. PSA after Lupron 1/6/10 of 19.5, 2/5/10 2.7 N2M1c

  8. #8
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    If you can afford to travel to one of the major cancer research centers like Johns-Hopkins or Dana-Farber and have the "A" team go over your case records it might be worth the effort. At your age, you need to be SURE you are doing everything possible.

  9. #9
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    I have an appointment with Dr. Scholz in LA on June 28 to discuss this treatment, etc. I am hopeful that we will get some new insight from someone who deals only in PCa.
    Age 39 DRE 11/12/09, biopsy 11/23/09-positive in 12 of 13 cores, GS 9, PSA 158, CT Scan - bladder, lymph nodes, Bone Scan- Hips, Pelvis, Ribs, Spine, Shoulder Blades, Sternum. PSA after Lupron 1/6/10 of 19.5, 2/5/10 2.7 N2M1c

 
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