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Thread: Lymphoma ABVD / BEACOPP Response adapted trial.

  1. #1
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    Lymphoma ABVD / BEACOPP Response adapted trial.

    http://clinicaltrials.gov/ct2/show/N...opp+pet&rank=1

    I am starting this trial this week, Oct 24 2010.

    It's in the national registry (Thanks Brainman) but I thought I'd add it specifically in case anyone wants to ask me questions after or during the trial.

    Using pet scans after 2 cycles of ABVD, the trial weighs the effectiveness of switching to BEACOPP if the patient is not progressing well enough with just ABVD.

    As I see it, it gives me an option to switch if ABVD is not working. A choice I'd not have in standard treatment.

  2. #2
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    Hi Jim,
    Didn't see any update on the status of your trial, just wondering if you felt it was fruitful.
    Natasha

  3. #3
    Administrator Top User Didee's Avatar
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    I don't know that you will get any reply as the thread is from 2010.
    Aussie, age 57
    1987 CIN 111. Cervix lasered, no further problems.

    Dx Peripheral T Cell Lymphoma stage 2B bulky, aggressive Dec/09.
    6 chop14 and Neulasta.
    Clean PET April/10, 18 rads 36gy mop up. All done May 2010
    Iffy scan Nov. 2011.
    Scan Feb 2012 .still in remission.
    Still NED Nov 2012. On to yearly bloods now.

    May/2012. U/sound, thyroid scan, FNB. Benign adenoma. A lump in otherwords, nodule if you wish to be specific.

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  4. #4
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    Well I guess I should stop by here more often than every 6months. I'm happy I participated in this particular trial. To be honest the treatment wasn't all that different from standard ABVD. The purpose was to determine if a PET scan after 2 cycles can predict "sort of" the outcome of the treatment. In the US, mostly ABVD is used for HL. According to study if after two cycles you are PET positive, you switch to BEACOPP for the remainder of treatment. My PET was negative after two cycles so I continued ABVD for 4 more cycles.

    The odd thing was that after 6cycles my PET showed a few new areas of concern, 3 months later all clear again.

    The main benefits of the trial were that I had more extensive testing on Lungs, heart etc. before treatment started. When I had some pulmonary embolisms and pneumonia during the 5th month of treatment, they had a good benchmark to determine the extent of the damage. I also felt better knowing that the data collected may help others make decisions in the future if you have a choice between ABVD or BEACOPP.

    18 months after finishing chemo, still clear and no regrets about choices. Sorry reply took so long, I'll try to stick around for awhile this time if anyone has questions about the trial or cancer care in upstate NewYork.
    Age 52 Rochester, NY
    2001 Diagnosed Stage 1 testicular Cancer
    Orchiectomy, Abdominal lymph system radiation 20 treatments
    August 2010 Diagnosed Stage 3b Hodgkins Lymphoma Mixed Cellularity
    6 Cycles ABVD
    Pneumonia, blood clots in legs, pulmonary embolism
    6 months Lovenox and fragmin injections, 2x daily
    Remission July 2012

    2013 August some b symptoms returning.
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