A website for discussions about any type of cancer, including lung cancer, breast cancer, prostate cancer, laryngeal cancer, leukemia, lymphoma, multiple myeloma and others
+ Reply to Thread
Results 1 to 4 of 4

Thread: rapidly rising psa bx neg x1

  1. #1
    Newbie New User
    Join Date
    Jun 2011
    Posts
    2

    rapidly rising psa bx neg x1

    Hi

    Here are my details:
    age 60 in excellent health Father died at 93 unrelated to his PCa or his low grade Bladder Ca which he had for over 15 years PCa treated with hormones and Bladder Ca treated 6 month periodic scrapings on cystoscopies
    psa 23.5 March 20, 2011
    psa 25.2 with simultaneous free psa of 9% May 17
    psa 34.00! on may 23 AM
    POST blood test: DRE and prosatic massage normal ( nothing expressed) May 23 evening
    Biposy on May 24 neg cores 12/12 no sign of inflammation or PIN totally benign
    Prosate size 61
    normal bone scan and cystoscopy
    Urologist doesn't want to refer me to MSKCC since bx neg
    MRI scheduled in 4 weeks presumably to be followed by repeat bx or I will try to talk them into MRI directed bx

    Anyone with an explanation how psa could rise 9 points in 6 days after rising 1.5 points in 2 months? Could that be a result of inflammation despite none found on bx?

    tia
    Last edited by freepsa; 06-05-2011 at 05:12 PM. Reason: clarification

  2. #2
    Top User
    Join Date
    Jun 2010
    Location
    Denver
    Posts
    1,280
    Your prostate is twice normal size, but that alone does not produce a PSA of 34...First step would be a run of antibiotics and see how the PSA responds to that..If no response, I would have a Color Doppler Ultrasound examination performed by an expert, even if if it means traveling to have this examination performed..Another option is a 40 core saturation biopsy..

    In a few rare cases, the PC can hide in spots unreachable by the TRUS 12 core biopsy procedure..But with a PSA of 34, SOMETHING is going on and Urologists get paid to find out what that something is....
    PSA at age 55: 3.5, DRE negative.
    65: 8.5, DRE " normal", biopsy, 12 core, negative...
    66 9.0 DRE "normal", BPH, (Proscar)
    67 4.5 DRE "normal" second biopsy, negative.
    67.5 5.6, DRE "normal" U-doc worried..
    age 68, 7.0, third biopsy (June 2010) positive for cancer in 4 cores, 2 cores Gleason 6, one core Gleason 7. one core Gleason 9. RALP on Sept. 3, 2010, Positive margin, post-op PSA. 0.9, SRT , HT. Feb.2011 PSA <0.1 Oct 2011 <0.1 Feb 2012 <0.01 Sept 2012 0.8 June 2013 1.1, Casodex added, PSA 0.04 10/2013. PSA 0.32 1/14. On 6/14 PSA 0.4, "T"-5. 10/14 PSA 0.6, T-11

  3. #3
    Newbie New User
    Join Date
    Jun 2011
    Posts
    2
    Ok, let me try this: A jump of 25 to 34 in 6 days could be explained by:
    a) normal fluctuations with large margin of error
    b) rapid malignant PCa curently confined mainly to anterior or transition zone and thus not found on 12 core
    c) an inflammatory process that got suddenly worse

    I bet on c as the most logical. Why would PSA climb 1-1/2 points in 2 months and then jump 9 points in 6 days. Any takers other than my insurance company?

  4. #4
    Top User
    Join Date
    Jun 2010
    Location
    Denver
    Posts
    1,280
    Any "insult" to the prostate gland..Having sex, horseback riding, bicycle riding, any major physical exertion can cause a temporary spike in PSA levels...Having wild swings in PSA levels while not common happen often enough so that, BY ITSELF, is no a cause for great concern..Again, have you been treated with a run of antibiotics to see what the response to that is? If you move the decimal point in one notch, you went from 2.5 to 3.4, a fairly common fluctuation percentage-wise..I would be MUCH more concerned that my PSA was over 20 and I needed to find out what was going on...

 
+ Reply to Thread

Similar Threads

  1. How rapid is a rapidly growing lymph node?
    By lumpy in forum Lymphoma - Hodgkin's and Non-Hodgkin's Lymphoma Forum
    Replies: 1
    Last Post: 08-24-2012, 07:15 AM
  2. Dad is deteriorating rapidly
    By MarDav in forum Pancreatic Cancer Forum
    Replies: 13
    Last Post: 01-29-2012, 11:46 AM
  3. Rapidly appearing moles
    By Rubin in forum Melanoma and Skin Cancer Forum
    Replies: 1
    Last Post: 11-15-2011, 02:22 AM
  4. Mel Metastatic Tumors Shrink Rapidly in Euro-PLX4032 Trial
    By HaoleBoy in forum Melanoma and Skin Cancer Forum
    Replies: 0
    Last Post: 10-28-2009, 01:46 AM
  5. PSA Rising (I think) after RP - (SRT ???)
    By Hawk in forum Prostate Cancer Forum
    Replies: 1
    Last Post: 08-21-2008, 07:07 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts