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Thread: Folfirinox did not work

  1. #1
    Senior User angelamylove's Avatar
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    Folfirinox did not work

    Hello everyone: When to go see the oncologist this morning about getting results from the latest CT Scan that was done in late December. It was not good news. More cancer showed up in her liver and some of the existing tumours increased in size. Did not go over very well when my wife heard the doctor telling. The doctor could only do so much to console after the news came out and I myself wanted to cry with her, but had to stay strong and be her shoulder to cry on. We are now going to start another regime with another chemo, it starts with a G, my mind is playing tricks on me while I type this. It will be 3 weeks in a row once a week and hen a week off then again and then again. Then another CT Scan and see where everything stands. It is a worse waiting game now because all you think about now is that is this chemo going to work better than the other.

    We hope and pray that this will be controlled after this chemo or we try something else if my wife wants to.

    Sorry for the bad news, just had to get it out of me.

    Thanks

    Peter

  2. #2
    Senior User angelamylove's Avatar
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    Folfirinox did not work

    Hello everyone: When to go see the oncologist this morning about getting results from the latest CT Scan that was done in late December. It was not good news. More cancer showed up in her liver and some of the existing tumours increased in size. Did not go over very well when my wife heard the doctor telling. The doctor could only do so much to console after the news came out and I myself wanted to cry with her, but had to stay strong and be her shoulder to cry on. We are now going to start another regime with another chemo, it starts with a G, my mind is playing tricks on me while I type this. It will be 3 weeks in a row once a week and hen a week off then again and then again. Then another CT Scan and see where everything stands. It is a worse waiting game now because all you think about now is that is this chemo going to work better than the other.

    We hope and pray that this will be controlled after this chemo or we try something else if my wife wants to.

    Sorry for the bad news, just had to get it out of me.

    Thanks

    Peter

  3. #3
    Top User Queensville's Avatar
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    Hi Peter, I'm so sorry to hear this news. Would it be Gemcitabine that she is starting? It's important to get this info you can make an informed choice. Call the doctors office and ask now before it starts because in ontario we only get three types of treatment that OHIP will pay for and if it is something that you are not in agreement with then you will have time to consider other options. Also have a look at the clinical trial thread. My hubby took Abraxane and that is a good option.

    I think it may still be in the trial phase but it's worth a shot.

    One of the things that helped us with decision making was to research the chemo that was being offered and what the prognosis was while on it.

    Queensville
    July 22 2011 Hubby (64) Diagnosed PanCan. Sept2011- Feb 2012: Abraxane/Gemcitabine. Feb-May 2012:Gemcitabine only. June-Sept 2012 5FU. Sept 4-no more chemo - Just living life. Multiple stents. Jan 2013/18 month mark. Mets everywhere. Looking for a bumper sticker that says 'Stay at safe distance - Driver suffering caregiver burnout'. Hospice Thurs Feb 28 2013. March 12 2013 he went off to his new adventure where we will one day meet again. It was 20 months from date of diagnosis until now.

  4. #4
    Senior User Martha56's Avatar
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    Hi Peter. I'm so sorry to hear that the Folfirinox has stopped working. I know how you feel because the same thing happened with my Husband. He is now on a chemo combination of Gemcitibine with Abraxane. It is the same schedule as your wife's new chemo. Three weeks in a row then a week off. My husband will have his 4th treatment tomorrow. It sounds like your wife may only be getting the Gemcitibine. We have the Abraxane approved for my Husband through a compassionate care program. If you want to try this chemo you could ask your oncologist about it. We live in Ontario also so you should be able to access this program if your doctor thinks it is suitable for your wife. There is a "sticky" at the top of the page regarding this type of chemo combination. I know the bad news knocked the wind out of us for awhile but try to regroup and get your strength up for the next chemo....there is still hope!! My prayers are with you both.
    Martha
    Husband 51 yrs. old diagnosed May 11, 2012 StageIV PC, 7.3 cm tumour on tail of pancreas with mets to liver, lungs, caked omentum, malignant ascites.
    June 2012 started Folfirinox
    CT scan after 6 treatments shows cancer is stable with slight shrinkage to studding on abdominal wall.
    Going for 6 more treatments then another CT.
    October: oncologist says bloodwork is excellent, same as someone not having chemo!
    After 12 treatments the CT shows folfirinox no longer working.
    Cancer has grown and spread more in lymph nodes in chest.
    Started abraxane /gemcitibine December 6th.
    Bone scan on Jan 24th shows mets to bones.
    No more abraxane / gemcitibine treatments
    Meeting with radiation oncologist & primary oncologist Feb. 14th.
    Since January been having thoracentisis for fluid around the lungs in addition to the paracentisis for ascites.
    Went to Emergency Feb.12/13 due to numbness in legs. Started 1st of 5 radiation treatments for acute spinal cord compression. Also diagnosed with blood infection, iv antibiotics started and blood cultures done.
    No improvement from radiation treatments. Paralyzed from waist down.
    Blood cultures identify bacteria, antibiotic is correct according to infection specialist but after 10 days still septic.
    Doctors meet with us and state they have no other treatment available and hubby's health is too poor for a clinical trial
    Feb.24/13 come home from hospital
    March 7, 2013 @ 11:55 am passed away with his loving family at his side.

    "Forever In My Heart" - Derek Joseph Greene, 1961 - 2013



    "Never Give Up"

  5. #5
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    Dear Peter, I am sorry that the Folfirinox didn't work well for her. It worked for my husband for a while. He is now on the Gemzar (Gemcitibine). He gets scanned on the 7th so see if it is doing any good. Different chemos work for different people, so maybe this will be the right one for your wife. It is supposed to have fewer side effects. Sending you good wishes and prayers.
    Lise
    "May you be held in compassion; May your pain and suffering be eased; May you be at Peace"

  6. #6
    Senior User
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    Well, we are all here to listen, Peter.
    Maybe the new drug is Gemzar? That's what my husband is on...same schedule that they have outlined for your wife. We have 2 more weeks, then a week off, then the CT scan. And, like you, we will be hoping for some good news...
    Your wife is lucky to have you there to support her and be strong for her. I sometimes wonder how people who do not have partners manage to get through something like this.
    Wishing you both better luck with the new chemo,
    Dori
    Nov 12, 2012 - husband diagnosed with pancreatic cancer. Sky fell. (Well, it felt like it did.)
    Nov 13, 2012 - canceled trips to Europe, New Orleans, and an 80 day cruise.
    Nov 29, 2012 - began chemo with Gemzar
    January 7, 2013 - ended chemo, began hospice
    March 17, 2013 - lost my best friend

  7. #7
    Regular User
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    Peter I'm so sorry to hear about your wife. Unfortunately, most pancan stage IV patients will receive this horrible news at one point (some sooner than others).

    I try to think of it the way my mother's doctor explained it last month. His outlook was that its not about the length of time that someone lives with pancan, but their quality of life. It is so difficult and I battle with it daily, but I also have to be realistic about the prognosis. As long as chemo is helping manage my mother's pain, then its ok in my book regardless of the progression of the tumors. Ultimately, I think that's the best you can ask for in this awful position that we are in

    If your wife is going on Gemcitibine, ask about pairing it with Abraxane. Clinical trials show that combination to have a statistically better result than Gemcitibine alone.

  8. #8
    Newbie Regular User
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    Hello Peter. My Dad is going through the same thing right now. I took him for a CT scan on New Year's Eve. We had a PET scan done before, which led to the CT. We spoke with the Doc, and it sounds like we are switching to Gemcitabine also. My thoughts and prayers are with you and your wife. This is such a challenging time, all you want is some sort of good news to keep the hope alive. My dad has not received a lick of good news since diagnosis. He broke down to me yesterday and said "I'm going to beat this." He's exhausted from the folfirinox and everything is a challenge. Here's to hoping that the Gemcitabine does wonders for our loved ones!

  9. #9

    Us Too..

    We had this same oncologist visit in August, Peter. I know how hard it is. Like you, we were strong for Mom who actually handled the news remarkably well, but I wanted to hug her and cry. I was just thankful we were not out of options. I am so, so sorry Peter. I will be praying the Gemzar is very effective at knocking the cancer back down. We just have to live one day at a time with our loved one who is sick, remember to breathe, and pray! Blessings to you and your family!!!

  10. #10
    Senior User
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    I would go all out to combine with abraxine. My dad had gemcetabine alone it did nothing. They are trialing various things with gemcetabine to make it more effective. Good luck, it's good you have other options, try stay positive...

 

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