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Thread: LCIS vs cancerization of lobules

  1. #1
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    LCIS vs cancerization of lobules

    Dr. Leo, what is the difference between these two?

    A.A.
    Dx Dec 2001 at age 50
    Lumpectomy Jan 2002, 1.6 cm IDC plus some DCIS
    Node neg
    ER+, PR+, HER2+++
    CAF x 6, 35 rads+boost, 1 3/4 yr tamoxifen,
    No taxane, no trastuzumab, no aromatase inhibitor
    NED
    Tamoxfen 1 3/4 yrs
    In 2 clinical trials
    bc for mom and 1 sis and 1 aunt and 1 granny
    ovarian cancer for 1 aunt

  2. #2
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    Are you asking about Invasive Lobular vs. Lobular In Situ?
    Nancy
    2/14/02 ILC 43 - 5.5 cm 9+/16 nodes
    Stage IIIA er/pr+ Her2-
    2/02 MRM
    FECx6 radsx33
    Tamoxifen - Arimidex (chemo induced menopause)
    4/03 SM w/bilat. recon.
    9/03 expanders removed
    5/04 repair reconst. disaster
    10/04 Actonel for bone/joint pain from Arimidex
    NED - 5 years
    3/07 Diabetes
    In memory of Kim 12/1/04

  3. #3
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    LCIS vs cancerization of lobules

    RE: LCIS vs cancerization of lobules

    I don't know.... In the report I was reading I got the impression that cancerization of the lobules wasn't the same thing as invasive lobular cancer, so I'm confused.
    Dx Dec 2001 at age 50
    Lumpectomy Jan 2002, 1.6 cm IDC plus some DCIS
    Node neg
    ER+, PR+, HER2+++
    CAF x 6, 35 rads+boost, 1 3/4 yr tamoxifen,
    No taxane, no trastuzumab, no aromatase inhibitor
    NED
    Tamoxfen 1 3/4 yrs
    In 2 clinical trials
    bc for mom and 1 sis and 1 aunt and 1 granny
    ovarian cancer for 1 aunt

  4. #4
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    Check these out until Leo can answer you directly.
    http://www.breastdiseases.com/dcispat2.htm

    http://www.medhelp.org/forums/Breast...ges/1748a.html

    Cancerization of lobules" refers to extension into the lobules and should be ... Q. What histology code for: excisional breast BX "Invasive ductal CA ...
    http://fcds.med.miami.edu/memos/99-0708memo.html

    Nancy
    Nancy
    2/14/02 ILC 43 - 5.5 cm 9+/16 nodes
    Stage IIIA er/pr+ Her2-
    2/02 MRM
    FECx6 radsx33
    Tamoxifen - Arimidex (chemo induced menopause)
    4/03 SM w/bilat. recon.
    9/03 expanders removed
    5/04 repair reconst. disaster
    10/04 Actonel for bone/joint pain from Arimidex
    NED - 5 years
    3/07 Diabetes
    In memory of Kim 12/1/04

  5. #5
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    DCIS vs cancerization of lobules

    RE: DCIS vs cancerization of lobules

    Thanks. The mental picture I have of "cancerization of lobules" is that the type of cells that normally line the ducts and have become DCIS have "spilled over" into the lobules, as either they have outgrown the space available inside the ducts... or else maybe they are ductal lining cells that were at the edge of the lobules and are simply multiplying into the lobules...??? and so these are cells that are in some way distinguishable in appearance from those that normally line the lobules (as well as distinguishable from LCIS)...?
    Dx Dec 2001 at age 50
    Lumpectomy Jan 2002, 1.6 cm IDC plus some DCIS
    Node neg
    ER+, PR+, HER2+++
    CAF x 6, 35 rads+boost, 1 3/4 yr tamoxifen,
    No taxane, no trastuzumab, no aromatase inhibitor
    NED
    Tamoxfen 1 3/4 yrs
    In 2 clinical trials
    bc for mom and 1 sis and 1 aunt and 1 granny
    ovarian cancer for 1 aunt

  6. #6
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    That's one thing about this disease. We know more then we wish we ever had to, but on the other hand, know very little.
    I was dx ILC so I definately don't know alot about IDC besides the fact that it is the most "common" kind of BC. I would think they couldn't call it DCIS if it had spilled over into the lobules. Isn't DCIS incapulated? I thought that is what in situ meant, but I could be very wrong so if it spilled over into the lobules, it would be IDC???????? Thank God for Leo because he can explain what it means and we can both learn. I wasn't trying to butt in, but wanted to give you those sites to look at until Leo could answer your question in case they could explain it.
    Sorry I was no help.
    Nancy
    Nancy
    2/14/02 ILC 43 - 5.5 cm 9+/16 nodes
    Stage IIIA er/pr+ Her2-
    2/02 MRM
    FECx6 radsx33
    Tamoxifen - Arimidex (chemo induced menopause)
    4/03 SM w/bilat. recon.
    9/03 expanders removed
    5/04 repair reconst. disaster
    10/04 Actonel for bone/joint pain from Arimidex
    NED - 5 years
    3/07 Diabetes
    In memory of Kim 12/1/04

  7. #7
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    Another good site with information on breast cancer is imaginis.com.
    Diagnosed 4/11/1996
    Lumpectomy, 6 mm tumor
    Neg. nodes
    ER/PR+
    33 rads
    Tamoxifen, 5 yrs.
    NED

  8. #8
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    DCIS vs cancerization of lobules

    RE: DCIS vs cancerization of lobules

    On the contrary, Muttsmom, I found your references helpful and interesting, so thanks very much for them. I just sort of fed back to you my interpretation of all of what I'd seen and read. Hopefully Leo will straighten all of us out if any of it is off-kilter!

    A.A.
    Dx Dec 2001 at age 50
    Lumpectomy Jan 2002, 1.6 cm IDC plus some DCIS
    Node neg
    ER+, PR+, HER2+++
    CAF x 6, 35 rads+boost, 1 3/4 yr tamoxifen,
    No taxane, no trastuzumab, no aromatase inhibitor
    NED
    Tamoxfen 1 3/4 yrs
    In 2 clinical trials
    bc for mom and 1 sis and 1 aunt and 1 granny
    ovarian cancer for 1 aunt

  9. #9
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    cancerization of lobules / DCIS

    Hello

    While it is an interesting question, these are all pathologist's terms that I often don't know what they mean. I'd have to call the pathologist and ask him what that exactly means. But by definition LCIS is in situ i.e. *no* invasion of the ductal lining.

    What cancerization of lobules means is that a *ductal* cancer extended into the lobular area. That does not mean it is a lobular tumor, it is just the DCIS growing into the lobule. It is only a finding, and does not make it invasive.

    best regards,
    Leo
    Leonardo F - Webmaster Cancer Forums
    Disclaimer: this information is for informational purposes only. It is not medical advice.

  10. #10
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    LCIS vs cancerization of lobules

    Thank you Dr. Leo.

    I didn't want to get any more complicated than necessary, or confuse anyone. I just didn't understand why cancerization of lobules (COL) wasn't the same thing as what is called lobular cancer, since the lobules were "cancerized"....

    It does make a difference for me personally with my path report and now I understand it better.

    A.A.
    Dx Dec 2001 at age 50
    Lumpectomy Jan 2002, 1.6 cm IDC plus some DCIS
    Node neg
    ER+, PR+, HER2+++
    CAF x 6, 35 rads+boost, 1 3/4 yr tamoxifen,
    No taxane, no trastuzumab, no aromatase inhibitor
    NED
    Tamoxfen 1 3/4 yrs
    In 2 clinical trials
    bc for mom and 1 sis and 1 aunt and 1 granny
    ovarian cancer for 1 aunt

  11. #11
    Top User
    Join Date
    Sep 2004
    Posts
    1,549
    Glad to help

    regards,
    Leo
    Leonardo F - Webmaster Cancer Forums
    Disclaimer: this information is for informational purposes only. It is not medical advice.

 
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