do you know about mushroom Extract Maitake D-fraction?
I was told by a friend to take Maitake D-fraction extract, which apparently fights against cancer cells and boost your immune system. I have been reading a lot about that mushroom extract and it sounds like a miracle cure. So, i bought it and started taking it a few days ago. But my husband says that i should check with my oncologist before doing so, as we don't know if there is any interference with Arimidex. Does anyone know about Maitake D-fraction and does it have any interactions? Thanks. Nicole
Hi Nicole. I 100% agree with your husband. ALWAYS consult with your own medical team before starting any supplement or alternative therapy. There is a risk of a supplement preventing your chemo from doing its work.
Another comment: If it sounds too good, like a "miracle cure" it probably is not. I do not even believe in a cancer being curable. It has been nearly 16 years since I was first diagnosed (Nov 1992). But it recurred almost 13 years later (June 2005). I use the term No Evidence of Disease (NED) instead of CURE (Complete and Utterly Ridiculous Expression ).
I am sorry about your cancer. You mind if I ask you what type of cancer you have?
It is being tested at the moment, and its effects on Chemotherapy is unknown, so I would suggest not taking it during treatment and waiting till after chemo has finished, until such times as it is pronounced safe. If this stuff costs a fortune I wouldn't bother and I would stick to the stuff that really works.
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Maitake mushrooms are widely eaten food. There's doesn't appear to be any problems with using Maitake D-fraction. If anything, you'll probably only have upside with it, since it's one of the more widely used and tested of the medical mushrooms and it's not new.
Many doctors are prescribing Maitake D-Fraction in Japan together with chemotherapy, especially for breast cancer, but also other cancers. In many cases it works synergistically so it enhances the effects of chemo and it protects the immune system by increasing NK cells and T cells which is what chemo will impact. Another one that is widely prescribed in hospitals in Japan is AHCC.
Our doctor usually prescribes 400-600 mg Maitake D-Fraction. Choose a high-potency Pro product for cancer, rather than the standard grade stuff. I guess sometimes you have to pay more for quality and potency. Too low a dose may not produce results. So far no problems taking 600mg of this for the last 2 months. NK cells increased from 29% to 41%, and T cell number increased from 491 to 1080 ul.
Although I completely trust my doctor's recommendations regarding alternative protocols I still like to do research on the supplements etc. that he suggests would be of benefit so that I have a better understanding of what effect they will have. Mushroom extracts have been a part of the daily supplement protocol I have followed since my diagnosis in early 2004.
There are many clinical trial reports available through such reliable sources as PubMed which clearly state that not only do many mushroom extracts (Maitake included) strengthen and optimize the capacity of the immune system, they also enhance the effectiveness of chemotherapy.
"Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity.1,2 In this non-random case series, a combination of MD-fraction and whole maitake powder was investigated to determine its effectiveness for 22- to 57-year-old cancer patients in stages II-IV. Cancer regression or significant symptom improvement was observed in 58.3 percent of liver cancer patients, 68.8 percent of breast cancer patients, and 62.5 percent of lung cancer patients. The trial found a less than 10-20 percent improvement for leukemia, stomach cancer, and brain cancer patients. Furthermore, when maitake was taken in addition to chemotherapy, immune-competent cell activities were enhanced 1.2-1.4 times, compared with chemotherapy alone. Animal studies have supported the use of maitake MD-fraction for cancer."
I wanted to comment on this discussion since I have a lot of inside information on this topic.
First I want to make clear that there is a big misunderstanding in terminology surrounding this topic. And it has to do with the words D fraction or MD fraction.
These words were originally created by Dr. Nanba of Kobe pharmaceutical university to name the series of fractions he purified from his extraction of the Maitake mushroom. Using column chromatography, he labeled different fractions of compounds A fraction, B fraction, C fraction, D fraction, etc.
And found that the purified, high molecular weight 1,6 beta glucans with 1,3 branches in this fraction (labeled D = the fourth fraction taken off the chromatography column)) had significant activity for stimulating immunocompetent cells.
He and his group of researchers have been publishing for over 15 years in Japan using these words to describe their patent protected extract. And ther research results are fantastic.
However these same terms "D fraction" and "MD fraction" have been trademarked by an American company in America, who also sells their own type of Maitake extracts.
So, it appears that 15 years of research in Japan and clinical trials at sloan kettering all are done on the commercial "D fraction" term patented in America. But that is not the case.
Please understand that the word "D fraction" published in most scientific papers is absolutely not the same as the "D fraction" being sold to you at your health food store.
The "D fraction" that is made by Dr. Nanba and his research team is a patented extract that has been further purified by chromatography methods to produce a super concentrated family of high molecualar weight compounds. It cannot be bought in the market place anywhere in the world because it is only an experimental scientific compound and no company currently makes this to sell.
To emphasize "you cannot actually buy the real D fraction published by Dr. Nanba anywhere in the world. It's not for sale. It does not exist on the market".
So issues about optimal dosage concentration and the dosages published in scientific papers do not correspond with any available Maitake extracts on the market.
I don't want to be a downer on this forum. Because actually I am a huge believer in the immune enhancing effects of Maitake extracts.
But I just wanted to shed some light on this subject, since I am one of the only people who have had access to this information.
PS. in America, Dr. Nanba's real patented Maitake extracts can be confirmed by the patent number 5,854,404. That is his patented Maitake extract.
Hope this helps to clarify the very blury naming and terminology surrounding this issue.
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Hi pbj11. That product mostly looks like a holistic type, since it contains alot of whole maitake mushroom. That is good, if you don't have access to fresh Maitake in your area.
For the extract it looks like one serving contains 10% of 30 mg. So 3mg of total extract (if my math is right). Please somebody correct me if I'm wrong.
This is not a very large dose of extract. But would probably be suitable for daily use for someone who is already healthy. Similar to putting a handfull mushrooms in your recipe for dinner.
So there IS benefit to be had from eating them.