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  1. The particular sequence of DNA that an organism...

    The particular sequence of DNA that an organism possesses (genotype), or mutational assay, does not determine what bodily or behavioral form (phenotype), or cellular assay, the organism will finally...
  2. Top 10 Reasons Against Routine Genomic Profiling of Tumors in Patient Care

    When they did comprehensive screening for gene mutations at MD Anderson, in a huge number of patients, they found an actionable target in 31%, but, of these 31%, only 10% responded to the targeted...
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    Immunotherapy actually works

    Larry M. Weisenthal, M.D., PhD., has the patent for a laboratory-testing method that identifies cancer patients who can benefit from new drugs designed to strengthen their immune systems. The testing...
  4. Paving the Way Forward with Biomarkers for Immunotherapy

    Thanks for these articles.

    Immune therapy drugs work by coaxing white blood cells that usually fight bacteria and viruses to kill cancer cells. For now, the drugs usually work in only about 20 to...
  5. The robust performance of drugs that target ALK...

    The robust performance of drugs that target ALK and EGFR has made testing for mutations in these genes routine. But as the cost of sequencing plummets, some clinicians believe that it makes more...
  6. Genomic analysis has proven to be harder to realize than expected

    Therapies targeted at the specific genetics of a patient's lung cancer have proved harder to realize than expected.

    Ramaswamy Govindan vividly remembers the first time he treated his patients with...
  7. Employing multi-dimensional analyses of both genomic and phenotypic platforms

    Robert A. Nagourney, M.D.

    Oncologists confront numerous hurdles as they attempt to apply the new cancer prognostic and predictive tests. Among them are the complexities of gene arrays that...
  8. Quest for Targeted Therapeutic 'Cocktails' Hits Roadblocks

    Mark Pegram, M.D.

    The use of cutting-edge technology and bioinformatics to inform clinical decision-making in oncology is still a ways off, according to Mark Pegram, MD, the Susy Yuan-Huey Hung...
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    United States vs Caris Life Sciences, Caris Diagnostics, Miraca Life Sciences

    It is familiar and makes me somewhat feel slightly ill, but it was refreshing to see that action is being taken. Just a note, however, that the fraud was not discovered by CMS but instead the case...
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    Mario I would agree with Didee about...

    Mario

    I would agree with Didee about participating on a heart forum. What is unique about this posting was the "interlocking" discovery from cancer research of a heart disease problem.

    The...
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    Big Data Meets Cancer: Neil Hunt at TEDxBeaconStreet

    https://www.youtube.com/watch?v=IWu6XWzbPBs

    The consistent and specific cure or control of cancer will require multiple drugs administered in combination targeted to abnormal patterns of normal...
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    An illustrated executive summary to explain what MCED is all about

    They made another discovery, a refinement to the elusive mechanism of arterial inflammation, which is in turn the triggering event in atherosclerosis. It's not simply massive calcium accumulation...
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    16th International Symposium on Anti-Angiogenic Therapy

    The 16th International Symposium on Anti-Angiogenic Therapy: Recent Advances and Future Directions in Basic and Clinical Cancer Research.

    Date:February 6-8, 2014

    Location:San Diego, California...
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    Predictive Biomarker for Anti-Angiogenic Therapy

    Endothelial Massive Calcium Accumulation Death (MCAD): Mechanism, Target, and Predictive Biomarker for Anti-Angiogenic Therapy

    Presented at the 13th international symposium on anti-angiogenic...
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    New Discoveries in Cancer and Heart Disease

    MCED: A newly-discovered mechanism of endothelial cell death

    Using a patented laboratory test, we have discovered a new cell death pathway in endothelial cells which we refer to as Massively...
  16. Those that can: do. Those that can't: change the rules!

    "These measures are 'the most important aims of treatment' in these patients because improvements in overall and progression-free survival (OS and PFS) have hit a ceiling in trial after trial of...
  17. Another One: New Endpoints Proposed for Chemotherapy in Ovarian Cancer

    Quality of life (QoL) and symptom benefit should be accepted by clinicians and regulators as additional coprimary endpoints in clinical trials of chemotherapies for platinum-resistant and refractory...
  18. The Meaning of Meaningful Improvement in Lung Cancer

    Robert A. Nagourney, M.D.

    When asked to define what constituted pornography in his 1964 Supreme Court decision (Jacobellis versus Ohio 1964) Justice Potter Stewart stated, “I know it when I see...
  19. Shifting Patterns in the Interpretation of Phase III Clinical Trial Outcomes in NSCLC

    Shifting Patterns in the Interpretation of Phase III Clinical Trial Outcomes in Advanced Non–Small-Cell Lung Cancer: The Bar Is Dropping

    Adrian G. Sacher, Lisa W. Le and Natasha B. Leighl
    ...
  20. Cyclin-dependent kinases as therapeutic targets

    Cyclin-dependent kinases as therapeutic targets: Examination of palbociclib (PD 0332991) and flavopiridol in human tumor primary culture microspheroids.

    Author(s): Robert Alan Nagourney, Eknath A....
  21. Those on Xalkori (crizotinib) but their NSCLC worsened or cannot tolerate taking it?

    Zykadia (ceritinib) is a new FDA-approved prescription medicine that is used to treat people with non-small cell lung cancer (NSCLC) that:

    * Is caused by a defect in a gene called anaplastic...
  22. The problem with ALK-rearranged NSCLC targeted drug Zykadia (ceritinib)

    Zykadia (ceritinib) being approved is a good thing as it is yet another drug that may provide good benefit for some or even possibly many people. The real question is whether it is right for a...
  23. FDA Approves Zykadia (Ceritinib) for ALK-Positive Lung Cancer

    A second drug that specifically targets non-small cell lung cancer (NSCLC) that is positive for the ALK gene rearrangement has been approved by the US Food and Drug Administration (FDA).

    The new...
  24. Palbociclib Extends PFS in ER-positive/HER2-negative Breast Cancer

    Treatment with palbociclib combined with letrozole resulted in significantly improved progression-free survival (PFS) compared with letrozole alone in patients with hormone receptor-positive...
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    Pati Your husband had a craniotomy already, so...

    Pati

    Your husband had a craniotomy already, so that rules out any suggestion of contacting Dr. Weisenthal (above) about having an assay done on his tumor to match which chemotherapy would have the...
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