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    There is an argument to be made to wait until...

    There is an argument to be made to wait until one's PSA is higher than 0.2 for the very reason that higher PSAs are more likely to result in positive scans. SRT done in the 0.2-0.5 range is still...
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    I would suggest that when typing decimal numbers...

    I would suggest that when typing decimal numbers less than one, we always use a leading zero. For example, 0.2 rather than .2, 0.34 rather than .34, and <0.1 rather than <.1 -- this is the way these...
  3. Thread: MRI Results

    by DjinTonic
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    899

    I don't see a way out of risk categories because...

    I don't see a way out of risk categories because (1) numbers aren't usually available, and (2) professional organizations and journal papers/studies use these precisely defined risk categories.
    ...
  4. Thread: MRI Results

    by DjinTonic
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    Yes, we each may evaluate risk differently. I...

    Yes, we each may evaluate risk differently. I would point out that the AS vs. treatment risk isn't all-or-nothing. Extremely few men who have to leave AS programs do so because of mPCa -- at the...
  5. Thread: MRI Results

    by DjinTonic
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    899

    Genomic testing, especially of biopsied tissue,...

    Genomic testing, especially of biopsied tissue, is not a prefect predictor by any means. But we shouldn't confuse genomic risk/prediction with Gleason score. We now know that low, average, and high...
  6. Thread: MRI Results

    by DjinTonic
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    38
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    899

    Whether or not a man of a certain advanced age...

    Whether or not a man of a certain advanced age with given PCa lesions needs treatment is an issue that's separate from the incidence of high-grade or aggressive lesions. If age is correlated with...
  7. Thread: MRI Results

    by DjinTonic
    Replies
    38
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    899

    With regard to age at diagnosis: More...

    With regard to age at diagnosis:

    More Aggressive Prostate Cancer in Elderly Men [2013, Full Text]



    Definitive Radiotherapy for Older Patients with Prostate Cancer: Experience of a Medical...
  8. Anticholinergics like oxybutynin are...

    Anticholinergics like oxybutynin are hit-and-miss. I had excruciating bladder spasms in the hospital after my TURP (triggered by tension put on the catheter to press again the surgical wound to stop...
  9. I posted the two sides of the recent Canadian...

    I posted the two sides of the recent Canadian debate to show that this is still just that -- an ongoing debate -- Also, for the near future at least, there may or may not be one treatment that has a...
  10. Primary treatment of the fossa is nonetheless...

    Primary treatment of the fossa is nonetheless recommended in many cases of mPCA because it leads to better outcomes. "Effective" is relative -- for some, it could mean a few years extra of...
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    Oligometastic PCa can be limited to the fossa and...

    Oligometastic PCa can be limited to the fossa and pelvis nodes and show PSA levels very much higher. (a PSA of 40 is not "ballistic"). All is not lost -- We don't have to speak about a "cure," but...
  12. BT-boost studies were indeed discussed, and I...

    BT-boost studies were indeed discussed, and I believe there were good reasons SBRT studies were not. Klotz points out the problems with using PSA recurrence rates rather than PCa-specific survival,...
  13. The High-Risk PCa Debate: Surgery vs Radiation

    CUOS 2019: High-Risk Prostate Cancer Debate: Surgery [2019, Full Text]

    [CUOS = Canadian Uro-Oncology Summit]



    (See Full Text)

    CUOS 2019: High-Risk Prostate Cancer Debate: Radiation [2019,...
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    [#148] CUOS 2019: High-Risk Prostate Cancer...

    [#148]
    CUOS 2019: High-Risk Prostate Cancer Debate: Surgery [2019, Full Text]

    [CUOS = Canadian Uro-Oncology Summit]
    ...
  15. [#127] Association between 5α-reductase...

    [#127]
    Association between 5α-reductase inhibitors therapy and incidence, cancer-specific mortality, and progression of prostate cancer: evidence from a meta-analysis [2019, Full Text]
    ...
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    [#147] How to choose proper local treatment in...

    [#147]
    How to choose proper local treatment in men aged ≥75 years with cT2 localized prostate cancer? [2019, Full Text]

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601593/
  17. Thread: MRI Results

    by DjinTonic
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    The reason for the additional tests is that the...

    The reason for the additional tests is that the patient has not disqualified AS. My hunch is, since the genomics test was favorable, only a G7 biopsy core might persuade him to treat.

    Djin
  18. Thread: MRI Results

    by DjinTonic
    Replies
    38
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    899

    That would speak only to formal AS programs at...

    That would speak only to formal AS programs at institutions. A doctor in practice wouldn't decline to actively monitor a patient who declines treatment, at least for now. Otherwise. what was the...
  19. Indeed, if the Phase III trial results are...

    Indeed, if the Phase III trial results are favorable, RT should gain more ground.

    See also this, just published:

    Hypofractionated radiotherapy versus conventional radiotherapy in patients with...
  20. Seven or less Fractions is Not the Standard of Care for Intermediate-Risk PCa

    Seven or less Fractions is Not the Standard of Care for Intermediate-Risk Prostate Cancer [2019, Review, Full Text]

    https://www.sciencedirect.com/science/article/pii/S0936655519304558



    Full...
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    [#129] Seven or less Fractions is Not the...

    [#129]
    Seven or less Fractions is Not the Standard of Care for Intermediate-Risk Prostate Cancer [2019, Review, Full Text]

    https://www.sciencedirect.com/science/article/pii/S0936655519304558

    ...
  22. [#75] Resveratrol induces depletion of TRAF6 and...

    [#75]
    Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proliferation and migration [2019]

    https://www.sciencedirect.com/science/article/abs/pii/S1357272519302213
  23. Thread: MRI Results

    by DjinTonic
    Replies
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    899

    Yes, surgery would solve both the PSA and BPH...

    Yes, surgery would solve both the PSA and BPH issue, but from other threads I understood that the purpose of the genomics test plus MRI and biopsy was because Murphy's husband was adamant about...
  24. Thread: MRI Results

    by DjinTonic
    Replies
    38
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    899

    OK, that's what I suspected ;). A score of 3 is...

    OK, that's what I suspected ;). A score of 3 is the gray area -- just as likely to be or not be cancer. But you already know G6 was found on prior biopsy, so I would take this as good MRI news: no...
  25. Thread: MRI Results

    by DjinTonic
    Replies
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    899

    Hi Murphy. There were three PIRAD lesions, which...

    Hi Murphy. There were three PIRAD lesions, which you list. These lesions are usually each given a PIRADS score from 1 to 5. Do you have these? Or were all three lesions PIRAD 3 lesions by...
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