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Thread: Intravenous Viral Therapy Phase I

  1. #1

    JX-594 Intravenous Viral Therapy Phase I

    http://www.nature.com/nature/journal...ture10358.html

    http://health.usnews.com/health-news...-shows-promise

    WEDNESDAY, Aug. 31 (HealthDay News) -- A new type of cancer treatment that uses a virus to infect and destroy tumor cells without harming normal cells is showing promise in early clinical trials.

    The small, Phase 1 trial involved 23 patients with advanced cancers that had spread to multiple organs and who had exhausted other treatment options.

    Each received an intravenous infusion of a virus called JX-594 at one of several dose levels. The virus was genetically engineered to contain an immune-stimulating gene to enhance its cancer-fighting properties, explained study co-senior author John Bell, a senior scientist at Ottawa Hospital Research Institution in Ontario, Canada.

    Patients underwent biopsies eight to 10 days later. In seven of eight patients (87 percent) who received the highest two doses, researchers found evidence that the virus had not only infected the tumor cells while sparing healthy cells, but that the virus was replicating. Replication means that the virus is reproducing and infecting neighboring cancer cells, rather than just infecting tumor cells it directly came into contact with.
    There was also evidence that the foreign immune-stimulating gene was expressed inside the tumor cells.

    "This is a landmark observation in that it shows it's possible that a virus can find tumors, specifically grow in tumors but not in regular tissues, replicate and destroy them," Bell said.

    The current trial was designed primarily to prove that it was both possible and safe to use a virus to infect tumor cells, and that the virus would then replicate. Side effects were minimal, with the main being brief and mild flu-like symptoms, researchers said.

    Though larger trials are needed to determine efficacy, about 75 percent of patients in the two highest dose groups also saw a shrinking or stabilization of their tumor, while those in lower dose groups were less likely to experience this effect, according to the study.

    "We didn't measure how well that specific immune-stimulating gene worked," Bell said. "But we definitely demonstrated the virus can go into the tumor, replicate only in the tumor and express a specific gene within the tumor."

    The findings are published in the September issue of Nature.

    One of the challenges in treating cancer is that cancer cells can spread into hard to find areas of the body, as well as in areas that can't be reached by a surgeon.

    "The holy grail is a virus that could travel through the blood, find the tumors where they may be hiding, infect them and kill them," Bell explained.

    Bell and his colleagues have been investigating cancer-fighting viruses for more than a decade. The virus, JX-594, is a distant relative of the smallpox virus; it's derived from a strain of vaccinia virus that has been used as a live vaccine in millions of people to vaccinate against small pox, Bell said.

    In another bit of good news, the virus still infected the tumor cells even though all of the people in the study had previously been exposed to it as part of their child vaccinations, according to the study.

    People in the study had several types of inoperable, advanced cancers, including lung, colorectal, melanoma, thyroid, pancreatic and ovarian. The virus can infect any type of epithelial, or surface cell, which are found throughout the digestive, reproductive, respiratory and urinary systems.

    Researchers are currently planning a larger randomized clinical trial for patients with liver cancer.

    William Phelps, director of preclinical and translational cancer research for the American Cancer Society, characterized the research as "preliminary, but really exciting."

    "Viruses have a great capacity for finding cells in certain parts of the body. They often tend to infect only certain types of cells," Phelps said. "If we can manipulate that and take advantage of the natural capacity of the virus to spread throughout the body and to very selectively infect only certain types of cells, that could be very promising."

    In this case, the virus contains "payload," or an extra gene that stimulates the immune system. "When the virus expresses that gene, it causes the immune system to kill the cell," he added. "It's very clever."
    Last edited by lancepeace; 09-01-2011 at 07:06 PM. Reason: amend title
    DOB Sept. 1947. Prostate cancer Gleason 7 (3+4), PSA 5 in Oct 2010. Cryoablation Jan. 2011. Had some complications.
    Experienced nocturia, irritable bladder summer 2011. "Agent Orange"compensation from VA Oct 2011.
    PSA: .05 01/26/2012, .06 6/26/2012, .04 12/24/2012, .04 6/26/13, .05 1/27/14, .05 10/21/14, .04 10/15
    I am eating vegan mostly plus a little fish. Take some supplements.
    (Any advice given is the personal opinion of a layman and is not intended to replace the advice of a health professional.)

  2. #2

    Virus therapy to cause cancer cell suicide.

    http://www.sciencedaily.com/releases...1018084639.htm

    The link above is about another viral therapy also from Canada.
    DOB Sept. 1947. Prostate cancer Gleason 7 (3+4), PSA 5 in Oct 2010. Cryoablation Jan. 2011. Had some complications.
    Experienced nocturia, irritable bladder summer 2011. "Agent Orange"compensation from VA Oct 2011.
    PSA: .05 01/26/2012, .06 6/26/2012, .04 12/24/2012, .04 6/26/13, .05 1/27/14, .05 10/21/14, .04 10/15
    I am eating vegan mostly plus a little fish. Take some supplements.
    (Any advice given is the personal opinion of a layman and is not intended to replace the advice of a health professional.)

  3. #3

    Virus Therapy at Ohio State Glioblastoma (animal study)

    http://www.sciencedaily.com/releases...1027173537.htm

    The link above is virus therapy for glioblastoma at Ohio State (animal study)
    DOB Sept. 1947. Prostate cancer Gleason 7 (3+4), PSA 5 in Oct 2010. Cryoablation Jan. 2011. Had some complications.
    Experienced nocturia, irritable bladder summer 2011. "Agent Orange"compensation from VA Oct 2011.
    PSA: .05 01/26/2012, .06 6/26/2012, .04 12/24/2012, .04 6/26/13, .05 1/27/14, .05 10/21/14, .04 10/15
    I am eating vegan mostly plus a little fish. Take some supplements.
    (Any advice given is the personal opinion of a layman and is not intended to replace the advice of a health professional.)

  4. #4
    Good information! Thanks for the links.
    Jim
    Long-term cancer survivor
    1992 Astrocytoma grade 2, left motor strip
    2005 Recurrence this time said to be an Oligodendroglioma grade 3, same location.
    http://cancerforums.net/viewtopic.php?t=2405
    My Story Part 1: http://cancerforums.net/viewtopic.php?t=2528
    My Story Part 2: http://cancerforums.net/viewtopic.php?p=7350
    My Story Part 3: http://cancerforums.net/viewtopic.php?t=8029

  5. #5
    Brainman, glad you liked the info.
    The article below is further results of JX-594 virus therapy:

    Smallpox vaccine extends life in cancer trial
    9:03am EDT 11/05/2011
    By Deena Beasley
    (Reuters) - A genetically engineered smallpox vaccine reduced the risk of death for patients with advanced liver cancer by nearly 60 percent in a mid-stage study, prompting the launch of a later-stage trial.
    Scientists at institutions including the University of California, San Diego, and privately held biotech company Jennerex Inc presented Phase 2 trial data on Saturday showing that patients given high doses of the altered vaccine, known as JX-594, lived for a median of 13.8 months compared with 6.7 months for patients treated with one-tenth of that dose.
    The small 30-patient study found that 66 percent of the high-dose patients were alive after one year, compared with 23 percent of the low-dose group.
    Temporary flu-like symptoms were the main side effect seen in the trial, which was presented in San Francisco at a meeting of the American Association for the Study of Liver Diseases.
    He said the first patient has been enrolled in a Phase 2b study comparing JX-594 with standard care in 120 liver cancer patients who have stopped responding to Nexavar, also known as sorafenib, sold by Onyx Pharmaceuticals.
    Patients in the trial will first be given an intravenous infusion of JX-594, followed by direct injections into the tumor. Dr. Kirn said the trial will also allow for more continuous dosing than in earlier studies.
    Jennerex plans to launch next year a Phase 3 head-to-head trial comparing JX-594 with Nexavar and is conducting earlier-stage trials in other types of cancer.
    Other forays into using engineered viruses include biotech giant Amgen Inc's deal in January to pay up to $1 billion for BioVex and its cancer drug development platform based on the herpes simplex virus.
    Amgen said last month that it had completed enrollment in a Phase 3 trial of the therapy in melanoma patients.
    (Reporting by Deena Beasley; Editing by Steve Orlofsky)
    Last edited by lancepeace; 11-05-2011 at 02:00 PM.

  6. #6
    Regular User
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    Don`t know if anyone follows this post any longer, but wanted to say that I really support such new discoveries and am glad to see progress!
    I can add virotherapy with Rigvir (cannot post a link, but you can try google it) which is very popular in east Europe, but, as my local media predicts, will be exported widely soon enough.

  7. #7
    Top User
    Join Date
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    Not in the U.S. anytime soon. I don't see where it's even undergone clinical trials yet.

  8. #8
    http://www.sciencedaily.com/releases...0301142941.htm

    http://en.wikipedia.org/wiki/Viral_vector

    Injection of viral vector into brain for glioblastoma. One Phase I trial and one Phase I/II trial.

  9. #9
    http://www.sciencedaily.com/releases...0613145352.htm

    Injection of virus in UK hitchhikes on blood cells to find and fight cancer cells.

    http://stm.sciencemag.org/content/4/138/138ra77

  10. #10
    Experienced User
    Join Date
    Aug 2012
    Posts
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    Interesting... it seems that science sometimes revisits their own flaws...

    "The relationship between intercurrent infection and fever and cancer remission has been recorded in the medical literature since the 1700s. In the late 1800s, Dr. William B. Coley, a young surgeon in New York, was prompted by the loss of his first patient to a sarcoma on her arm to search for information that might help him treat other patients with similar conditions. In his search, he found many reports where cancer remission occurred after an acute bacterial infection, usually erysipelas. Coley reasoned if he injected tumors with erysipelas perhaps he could cause remission. He pursued his ideas, and, after many experiments with different combinations of bacteria and preparation techniques, Coley developed a mixture of two heat-killed bacterias, Streptococcus pyogenes (the causative bacteria for erysipelas) and Serratia marcescens, that successfully induced remission in a number of cancer patients. This mixture became known as Coley’s toxins, or Mixed Bacterial Toxins as it is now called. The treatment caused a high fever, and, in fact, Coley found that a sustained fever of 102 to 105 degrees F. for at least 24 hours was necessary to produce any effect. Coley’s toxins were used in 210 cases of inoperable cancer before 1940. In 104 cases of soft tissue sarcomas, 50% of those injected with the toxins lived from 5 to over 20 years. The success rate with other types of cancer was not as high. For example, out of 50 cases of lymphomas, 19 or 38% lived from 5 to over 20 years, but out of 14 cases of breast cancer, only 2 people survived five years."

    Of course, erysipella treatment is no longer used...

    See http://media.noetic.org/uploads/files/App4.pdf for some articles on this issue, from the early XX century almost to nineties.

    Hugs
    Oct. 2009, My wife, 55, massive pleural effusion, Stage IV NSCLC - Adenocarcinoma
    Nov. 2009, Pleurodesis, excellent outcome
    Dec. 2009, CT did not show any lung nodule...only a small < 1cm lung fibrosis (scar)
    Dec. 2009, Began Carboplatin+Paclitaxel, 6 cycles
    Mar. 2010, CT, 2,4 cm left lower lung nodule
    Oct. 2010, Tumor progressed, 3,5 cm,
    Oct. 2010, Failed cisplatin+vinolrebine, after 1 cycle, low platelet count
    Feb. 2011, Failed pemetrexed after 2 cycles, strong anemia, skin edema and infection
    Mar. 2011, tumor progression 5 cm
    Apr. 2011, strong dyspnea, need for 24h/day O2, oncologist had no additional resources. Fentanyl failure, strong dizziness.
    Mai. 2011, tumor progression 6 cm, 2 mets detected in the liver. Daily morphine
    Jun. 2011, palliative radiation to chest, 22 sessions, partial sucesss, managed to walk again after 4 months in bed
    Aug. 2011 kidney and respiratory failure.

 

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