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Thread: Innovative breast cancer treatment UK

  1. #1
    Super Moderator Top User Baz10's Avatar
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    Innovative breast cancer treatment UK

    Watched on the ITV UK evening news a report on a new procedure for the treatment of breast cancer and as they stated it could be applicable to other forms of cancer.
    I'll condense the report as best I can
    This procedure requires a one day hospital stay, where the patient is given a shallow general anesthetic , chemotherapy drugs are introduced slowly intravenously injected.30 minutes after chemo is given, the specialist introduces a small diameter probe to the tumor or cancer sites(s) and commences passing a electrical current through the probe.
    As the report stated the electrical current apparently breaks down the resistance of the cancer cells to chemotherapy drugs.
    Although it was not specific, seems that they mix some form of carrier into the chemo cocktail which carries the chemotherapy drugs directly to the site of the cancer. So it is targeted treatment which according to the report makes the chemotherapy drugs 8,000 times more effective than conventional general chemotherapy.
    In effect all the chemotherapy drugs given during this procedure are attracted to the area of the probe and the site it literally overwhelmed by the drugs.
    The report stated that within days all cancer cells are destroyed.
    As there is only 1 chemotherapy treatment given there are negligible side affects and generally the patient is discharged the same day.
    Apparently this procedure has Ben trialled and tested and will become the NHS first line of treatment for breast cancer and other forms of cancer.
    It showed a mother and daughter who had the hereditary gene where the mom had had previously 6 breast cancer occurences and following this procedure was pronounced cancer free, the daughter similarly after 1 procedure was given the same result.
    The report can be viewed
    ITV.com/news
    Heading Latest weapon in the treatment of breast cancer and other forms of cancer.
    It's definitely worth viewing and may give hope to this treatment being generally introduced within our NHS system in the UK
    Barry
    Diagnosed stage 3 March 011
    Radical resection April 011
    Restaged 2b April 011.
    12/09 Colonoscopy clear but picked up hospital infection.
    Aorta & femoral arteries occluded.
    Clot buster drugs put me in ICU with internal bleeding. 9 blood units later they got it under control.
    Aortobifemoral surgery 5th May. yughh.
    PET scan indicates clear
    DEXA bone scan clear
    13/5 CT showed "unknown" but no concern from docs.
    Inguinal lymph nodes and severe groin pain.
    Ultrasound and MRI show no nasties. Pheww
    Groin pain and enlarged lymph nodes still there.
    October -still the same pains but under semi control.
    Additional chest CT scan ordered for 11th November prior to surgery.
    Sinus surgery done and dusted.
    July 2014 PSA at 5.10. 2months of antibiotics in case of UTI, jan 2015 PSA at 7.20.
    Prostate Cancer confirmed Gleason 3+3.
    Active surveillance for time being.
    Just a little recurrence and another 20 cm of colon vanished under the knife.

    Not all's rosy in the garden, but see following.
    Stop grumbling Baz, your still alive and kicking so far.
    Age and illness doesn't define who we are, but more what we are able to do.
    Motto
    Do what I love doing, when I can until I can't.
    and dodging bullets in the meanwhile.

  2. #2
    Administrator Top User Didee's Avatar
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    THank you Baz.

    I am going to sticky this so it doesn't get lost.
    Aussie, age 59
    1987 CIN 111. Cervix lasered, no further problems.

    Years of pain, bleeding, women's plumbing problems. TV ultrasound, tests, eventual hysterectomy 2007, fibroids in lining of Uterus.

    Dx Peripheral T Cell Lymphoma stage 2B bulky, aggressive Dec/09.
    6 chop14 and Neulasta.
    Clean PET April/10, 18 rads 36gy mop up. All done May 2010
    Iffy scan Nov. 2011. Scan Feb 2012 .still in remission.Still NED Nov 2012.
    Discharged Nov 2014.

    May/2012. U/sound, thyroid scan, FNB. Benign adenoma.

    Relapse Apr 2016. AITL. Some chemos then on to allo or hap transplant. Onc says long remission was good. Still very fixable. All I needed to hear. I am pumped and ready. BRING IT ON

  3. #3
    Super Moderator Top User Baz10's Avatar
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    Hi Didee, hope your doing well,
    It was a seriously interesting report although only about 5 minutes showing the procedure and interviewing the consultant and the mom and daughter, it was extremely enlightening that what apparently is a relatively simple procedure can be so effective and appears so effective as it stated that generally only 1 procedure was required as it is so effective.
    Best regards
    Barry
    Diagnosed stage 3 March 011
    Radical resection April 011
    Restaged 2b April 011.
    12/09 Colonoscopy clear but picked up hospital infection.
    Aorta & femoral arteries occluded.
    Clot buster drugs put me in ICU with internal bleeding. 9 blood units later they got it under control.
    Aortobifemoral surgery 5th May. yughh.
    PET scan indicates clear
    DEXA bone scan clear
    13/5 CT showed "unknown" but no concern from docs.
    Inguinal lymph nodes and severe groin pain.
    Ultrasound and MRI show no nasties. Pheww
    Groin pain and enlarged lymph nodes still there.
    October -still the same pains but under semi control.
    Additional chest CT scan ordered for 11th November prior to surgery.
    Sinus surgery done and dusted.
    July 2014 PSA at 5.10. 2months of antibiotics in case of UTI, jan 2015 PSA at 7.20.
    Prostate Cancer confirmed Gleason 3+3.
    Active surveillance for time being.
    Just a little recurrence and another 20 cm of colon vanished under the knife.

    Not all's rosy in the garden, but see following.
    Stop grumbling Baz, your still alive and kicking so far.
    Age and illness doesn't define who we are, but more what we are able to do.
    Motto
    Do what I love doing, when I can until I can't.
    and dodging bullets in the meanwhile.

  4. #4
    Top User lancepeace's Avatar
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    http://en.wikipedia.org/wiki/Electrochemotherapy
    Posted: 09/30/2011
    By: NBC News
    LONDON (NBC) - British doctors believe they have a new weapon in the fight against breast cancer.
    Carol Wallace has had breast cancer six times.
    She and her daughter Lisa both have the gene that makes them susceptible to it.
    Carol has had surgery, radiotherapy and chemotherapy and when the cancer came back this year she was running out of options.
    So she tried an experimental operation being pioneered and offered at the Royal Hospital in London.
    It's called electrochemotherapy.
    It starts with a nurse slowly and carefully injecting an anti-cancer drug into Carol's arm.
    Doctors then wait eight minutes until it spreads through her body to the cancer on her chest and afterwards they will give an electric pulse which will make that chemotherapy even more effective.
    The surgeon uses these electrodes to pass a current into cancer cells that opens their cell walls and makes them eight [8,000 according to video] times more vulnerable to the chemotherapy.
    The operation takes about an hour.
    Conventional chemo can take six months and can have side-effects.
    Consulting Sugeon Mo Keschtgar said "whenever I give the electrical stimulation the cancer cells, the anti-cancer drug rushes into that area and basically starts killing the cancer within days."
    A month later and Carol's cancer has disappeared. It may return but the treatment can be repeated.
    "I would definitely have the treatment again should it reappear,” Carol said. “I wouldn't hesitate not for a minute. It's uncomfortable for a while, but better than chemotherapy."
    It will take many more patients like Carol to show just effective the new treatment really is.
    Last edited by lancepeace; 10-19-2011 at 01:33 PM. Reason: add 8,000 number from video
    DOB Sept. 1947. Prostate cancer Gleason 7 (3+4), PSA 5 in Oct 2010. Cryoablation Jan. 2011. Had some complications.
    Experienced nocturia, irritable bladder summer 2011. "Agent Orange"compensation from VA Oct 2011.
    PSA: .05 01/26/2012, .06 6/26/2012, .04 12/24/2012, .04 6/26/13, .05 1/27/14, .05 10/21/14, .04 10/15
    I am eating vegan mostly plus a little fish. Take some supplements.
    (Any advice given is the personal opinion of a layman and is not intended to replace the advice of a health professional.)

  5. #5
    Super Moderator Top User Baz10's Avatar
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    Lance,
    Good summary of the report I watched, just revisited the report and the only difference is that quote" this procedure makes the chemotherapy drugs 8,000 more effective than conventional chemotherapy".
    Best regards
    Barry
    Diagnosed stage 3 March 011
    Radical resection April 011
    Restaged 2b April 011.
    12/09 Colonoscopy clear but picked up hospital infection.
    Aorta & femoral arteries occluded.
    Clot buster drugs put me in ICU with internal bleeding. 9 blood units later they got it under control.
    Aortobifemoral surgery 5th May. yughh.
    PET scan indicates clear
    DEXA bone scan clear
    13/5 CT showed "unknown" but no concern from docs.
    Inguinal lymph nodes and severe groin pain.
    Ultrasound and MRI show no nasties. Pheww
    Groin pain and enlarged lymph nodes still there.
    October -still the same pains but under semi control.
    Additional chest CT scan ordered for 11th November prior to surgery.
    Sinus surgery done and dusted.
    July 2014 PSA at 5.10. 2months of antibiotics in case of UTI, jan 2015 PSA at 7.20.
    Prostate Cancer confirmed Gleason 3+3.
    Active surveillance for time being.
    Just a little recurrence and another 20 cm of colon vanished under the knife.

    Not all's rosy in the garden, but see following.
    Stop grumbling Baz, your still alive and kicking so far.
    Age and illness doesn't define who we are, but more what we are able to do.
    Motto
    Do what I love doing, when I can until I can't.
    and dodging bullets in the meanwhile.

  6. #6
    Regular User
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    I thought this sounded too good to be true so I researched the actual trials. The trouble with reporters and those who manage trials is that they have financial stakes in the efficacy of the drug. While a trial run by the pharmaceutical company that developed the drug often meets FDA standards enough to earn FDA approval, later trials that are independent are generally given more weight. It seems statistics may have been manipulated in this report. One patient's success is significant for us, because we are all on the cancer journey. For the FDA, they are not enough. Nor are they enough for the majority of patients. Here is a copy and paste that may provide some enlightenment on the issue. It was published earlier this month. Just to add, though, this is referring to a trial for electrochemotherapy for head and neck cancer. I don't have the time to unpack all the data on other trials, but the earlier trials for breast cancer on humans showed that the method could only be used to investigate whether or not chemotherapy was an option--in other words, it could be used only as a diagnostic tool. I would be curious to see what new information comes to light about the current phase of this trial that has just been reported, and whether or not it gets approval. For now, investors have all dropped their shares in the drug, which has been somewhat of a financial crisis for the pharmaceutical company.

    OncoSec's (ONCS.OB) phase 3 data announcement for its OMS ElectroChemotherapy trial using bleomycin for the treatment of head and neck cancer appeared to be positive. The company reported "no statistically significant differences between time to death or local control rate at eight months between the control and experimental groups for HNBE-01 or HNBE-02 or the combination of both studies. Median time to death was statistically indistinguishable between surgery at 209 days versus 231 days for electrochemotherapy (p=0.55). Local tumor control at eight months was achieved in 92% of control group patients versus 90% of electrochemotherapy patients." The Data Monitoring Committee (DCM) had recommended that enrollment of the two-part phase 3 trial be terminated back in May of 2007 due to both safety and efficacy concerns. However, OncoSec reported that after they had completed their own analysis of the data, they had concluded "there were no statistically significant differences between time to death or duration of local control between the control or ElectroChemotherapy experimental arms in either the HNBE-01 or HNBE-02 trials, or the combined groups across studies." The only truly noteworthy issue observed from the trials by the company was via comparisons of pain after treatment by surgery versus by the ElectroChemotherapy treatment with pain reported by 35.4% and 46% of patients, respectively. Although a concern, the difference may not be significant considering the OMS treatment doesn't have the scarring and disfigurement propensity that surgery may have in many patients, depending on the severity of the resections.
    Last edited by Kirsten; 08-30-2012 at 10:52 AM. Reason: post script

  7. #7
    Super Moderator Top User Baz10's Avatar
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    Kirtsen.
    The UK report was made by ITV (Independent Television Authority), it was neither sponsored or promoted by a drug manufacturer.
    The news report was based on a review by BMA (British Medical Association and Cancer Research UK) as was stated in the news report.
    It appears that you are referring to the US and not UK.
    I have revisited the news item and there is categorically no link between drug manufacturers and this report.
    The efficacy of this treatment appears to be very high, I assume for the selected recipients.
    I think it is wrong to infer that this applies to the US as it most definately does not in this case.
    The consultant and hospital stand by the results, and further please remember this treatment is carried out under our National Health
    Service which is a free to anyone at point of treatment government service, unlike the US or other parts of the world.
    I cant comment on the in depth analysis you have done, but it seems your referring to similar but different treatment methodology in another country, Not the UK hich as I said is national health service Not private hospitals
    Diagnosed stage 3 March 011
    Radical resection April 011
    Restaged 2b April 011.
    12/09 Colonoscopy clear but picked up hospital infection.
    Aorta & femoral arteries occluded.
    Clot buster drugs put me in ICU with internal bleeding. 9 blood units later they got it under control.
    Aortobifemoral surgery 5th May. yughh.
    PET scan indicates clear
    DEXA bone scan clear
    13/5 CT showed "unknown" but no concern from docs.
    Inguinal lymph nodes and severe groin pain.
    Ultrasound and MRI show no nasties. Pheww
    Groin pain and enlarged lymph nodes still there.
    October -still the same pains but under semi control.
    Additional chest CT scan ordered for 11th November prior to surgery.
    Sinus surgery done and dusted.
    July 2014 PSA at 5.10. 2months of antibiotics in case of UTI, jan 2015 PSA at 7.20.
    Prostate Cancer confirmed Gleason 3+3.
    Active surveillance for time being.
    Just a little recurrence and another 20 cm of colon vanished under the knife.

    Not all's rosy in the garden, but see following.
    Stop grumbling Baz, your still alive and kicking so far.
    Age and illness doesn't define who we are, but more what we are able to do.
    Motto
    Do what I love doing, when I can until I can't.
    and dodging bullets in the meanwhile.

  8. #8
    Regular User
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    I make no inference of any US association. The FDA's decisions affect the global medical community on a huge scale. In my country we don't receive drugs until they're FDA approved--I live in Africa. How localised a trial is also bares no impact on how countries treat them. The UK, for example, will demand certain trial criteria but will take into account what has been revealed in clinical trials on a global scale. Baz, it's not my intention to debate. It's just that I am a medical journalist and my eyes are very much open to the bias in reporting. Take into consideration the motives of the reporter--to break a great story. On top of that, who conducted the actual trial and who communicated its results to the journalist in question? These are the questions I ask when reading any medical reports. Electrochemotherapy has been in use since 1995. What the ITV report refers to is electrochemotherapy with a surgical delivery in which a particular agent is used for enhancement. Breast cancer is of particular interest to me as my mom is currently dying from it. I have gone through trial after trial on this treatment and it is indeed promising. I only state here that it is not a cure all, or a sure cure. It has, as yet, shown the promise required to encourage other trials. For this particular method, we need larger trial participant groups, as well as clinical trials for more cancers.

  9. #9
    Administrator Top User Didee's Avatar
    Join Date
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    Aussie, age 59
    1987 CIN 111. Cervix lasered, no further problems.

    Years of pain, bleeding, women's plumbing problems. TV ultrasound, tests, eventual hysterectomy 2007, fibroids in lining of Uterus.

    Dx Peripheral T Cell Lymphoma stage 2B bulky, aggressive Dec/09.
    6 chop14 and Neulasta.
    Clean PET April/10, 18 rads 36gy mop up. All done May 2010
    Iffy scan Nov. 2011. Scan Feb 2012 .still in remission.Still NED Nov 2012.
    Discharged Nov 2014.

    May/2012. U/sound, thyroid scan, FNB. Benign adenoma.

    Relapse Apr 2016. AITL. Some chemos then on to allo or hap transplant. Onc says long remission was good. Still very fixable. All I needed to hear. I am pumped and ready. BRING IT ON

  10. #10
    Super Moderator Top User Baz10's Avatar
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    Kirsten,
    There was no intention on my part to be critical. It appeared that as you referred to the FDA thereby a wrong assumption by me.
    I think we come from differing perspectives, you professionally, I from a point of interest where a "hopeful " treatment regime is reported as being highly successful for the participants.
    To hopefully clarify, I'm not promoting this treatment just reporting, as I have no involvement or connection with any drug company, nor from a medical perspective.
    I believe your third paragraph is in essence what I posted.
    I'm sorry to hear of your moms prognosis.
    My wife's mom and then stepmom died from breast cancer also my sister in law has had long term breast frights which has developed into an auto immune disease (Polychondritis), she is one of three known cases in the UK and knows she is living on borrowed time.
    Wish your mom and your family the very best.
    Barry
    Diagnosed stage 3 March 011
    Radical resection April 011
    Restaged 2b April 011.
    12/09 Colonoscopy clear but picked up hospital infection.
    Aorta & femoral arteries occluded.
    Clot buster drugs put me in ICU with internal bleeding. 9 blood units later they got it under control.
    Aortobifemoral surgery 5th May. yughh.
    PET scan indicates clear
    DEXA bone scan clear
    13/5 CT showed "unknown" but no concern from docs.
    Inguinal lymph nodes and severe groin pain.
    Ultrasound and MRI show no nasties. Pheww
    Groin pain and enlarged lymph nodes still there.
    October -still the same pains but under semi control.
    Additional chest CT scan ordered for 11th November prior to surgery.
    Sinus surgery done and dusted.
    July 2014 PSA at 5.10. 2months of antibiotics in case of UTI, jan 2015 PSA at 7.20.
    Prostate Cancer confirmed Gleason 3+3.
    Active surveillance for time being.
    Just a little recurrence and another 20 cm of colon vanished under the knife.

    Not all's rosy in the garden, but see following.
    Stop grumbling Baz, your still alive and kicking so far.
    Age and illness doesn't define who we are, but more what we are able to do.
    Motto
    Do what I love doing, when I can until I can't.
    and dodging bullets in the meanwhile.

 

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