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Thread: Mayo Clinic clears woman's Multiple Myeloma

  1. #1
    Moderator Top User HighlanderCFH's Avatar
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    Mayo Clinic clears woman's Multiple Myeloma

    Hello everyone,

    I'm jumping over for a moment from the Prostate Cancer forum to relate some exciting news I just saw a few minutes ago on the Fox News Channel.

    I don't know if anyone else has posted this yet, but Mayo Clinic just announced it has completely cleared up a woman's Multiple Myeloma with an experimental treatment.

    Thus, I thought this might be something significant that people in this forum wiill be interested in. I copy-pasted an article down below that I found from a Google search.

    I truly hope this development might lead to great hope for everyone afflicted with this disease.

    Take care,
    Chuck
    Moderator, Prostate Cancer forum

    ********************************

    Massive dose of measles vaccine clears woman's cancer

    Lindsey Seavert, KARE10:51 a.m. EDT May 15, 2014

    ROCHESTER, Minn. - Mayo Clinic researchers announced a landmark study where a massive dose of the measles vaccine, enough to inoculate 10 million people, wiped out a Minnesota woman's incurable blood cancer.

    The Mayo Clinic conducted the clinical trial last year using virotherapy. The method discovered the measles virus wiped out multiple myeloma cancer calls. Researchers engineered the measles virus (MV-NIS) in a single intravenous dose, making it selectively toxic to cancer cells.

    Stacy Erholtz, 49, of Pequot Lakes, was one of two patients in the study who received the dose last year, and after 10 years with multiple myeloma has been clear of the disease for over six months.

    "My mindset was I didn't have any other options available, so why wouldn't I do it? I had to have failed all conventional treatment to do that trial. That actually happened last March," Erholtz told KARE. "It was the easiest treatment by far with very few side effects. I hope it's the future of treating cancer infusion."

    Steven Russell, a Mayo Clinic hematologist, spearheaded the study and said the concept was previously tested in mice, but never in humans.

    "It's a huge milestone in that regard," said Russell. "We have known for some time viruses act like a vaccine. If you inject a virus into a tumor you can provoke the immune system to destroy that cancer and other cancers. This is different, it puts the virus into bloodstream, it infects and destroys the cancer, debulks it, and then the immune system can come and mop up the residue."

    Two multiple myeloma patients were chosen because they are immune-compromised, and can't fight off the measles before it has time to attack cancer. Both had limited previous exposure to measles, and therefore fewer antibodies to the virus, and essentially had no remaining treatment options. Of the two subjects in the study, Stacy was the only to reach full remission. The other patient's cancer returned after nine months.

    Russell believes it's still a medical milestone, and he hopes his team can one day transform this research into a single shot cure.

    "It's like a call to action. It's not just good for our virus. It's good for every virus everybody's developing as a cancer therapy. We know this can happen," said Russell.

    Mayo researchers are also testing the measles virus's effectiveness at fighting ovarian, brain, head and neck cancers and mesothelioma. They are also developing other viruses that seem to have potential to kill cancer cells.

    "I think it's just remarkable. Who would have thought?" said Erholtz, who said she returns to the Mayo in June for a check up.

    The Mayo is moving immediately into a phase two clinical trial involving more patients with a goal of FDA approval within four years.

    Patients interested in the upcoming clinic trial using measles vaccines to treat cancer can inquire here.

    http://www.usatoday.com/story/news/n...linic/9115363/
    July 2011 local PSA lab reading 6.41 (from 4.1 in 2009). Mayo Clinic PSA 9/ 2011 = 5.7.
    Local uro DRE revealed significant BPH, no lumps.
    PCa Dx Aug. 2011 age of 61.
    Biopsy DXd adenocarcinoma in 3/20 cores (one 5%, two 20%). T2C.
    Gleason 3+3=6. CT abdomen, bone scan negative.
    DaVinci prostatectomy 11/1/11 at Mayo Clinic (Rochester, MN), nerve sparing, age 62.
    Surgeon was Dr. Matthew Tollefson, who I highly recommend.
    Final pathology shows tumor confined to prostate.
    5 lymph nodes, seminal vesicules, extraprostatic soft tissue all negative.
    1.0 x 0.6 x 0.6 cm mass involving right posterior inferior, right posterior apex & left
    mid posterior prostate. Right posterior apex margin involved by tumor over 0.2 cm length,
    doctor says this is insignificant.
    Prostate 98 grams, tumor 2 grams.
    Catheter out in 7 days. No incontinence, minor dripping for a few weeks.
    Eight annual post-op exams 2012 through 2019: PSA <0.1
    Semi-firm erections without "training wheels," usable erections with 100mg Sildenafil.
    NOTE: ED caused by BPH, not the surgery.

  2. #2
    Moderator Top User HighlanderCFH's Avatar
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    I thought I should also seek out the Fox News Channel website to find their article on this, so here it is:

    Woman's cancer wiped out ... by measles virus
    By Rob QuinnPublished May 15, 2014Newser
    In a breakthrough that could offer new hope to people with some kinds of cancer, Mayo Clinic researchers say they managed to wipe out a woman's cancer with a blast of measles vaccine strong enough to inoculate 10 million people.

    The 50-year-old woman's blood cancer, which had spread through her body, went into complete remission after the vaccine dose and Stacy Erholtz has been clear of the disease for more than six months.

    "It's a landmark," lead researcher Dr. Stephen Russell tells the Minneapolis Star Tribune. "We've known for a long time that we can give a virus intravenously and destroy metastatic cancer in mice. Nobody's shown that you can do that in people before." And Erholtz's take on the approach is more than positive: "It was the easiest treatment by far with very few side effects. I hope it's the future of treating cancer infusion." The trial involved two patients with multiple myeloma, and the second failed to go into complete remission, with the cancer returning after nine months.

    KARE-11 reports the trial involved patients with multiple myeloma because their immune systems are so compromised they lack the ability to immediately fight off the measles, giving the virus time to attack the cancer; they also had no conventional treatment options left.

    Russell explains how the process works in layman's terms: "It puts the virus into bloodstream, it infects and destroys the cancer, debulks it, and then the immune system can come and mop up the residue." Up next: larger-scale studies, and tests of the vaccine's effectiveness against ovarian, brain, head, and neck cancers, as well as mesothelioma.

    They also plan to test vaccines for viruses other than measles, with the goal being to find a "single-shot" cure for many cancers.

    http://www.foxnews.com/health/2014/0...measles-virus/
    July 2011 local PSA lab reading 6.41 (from 4.1 in 2009). Mayo Clinic PSA 9/ 2011 = 5.7.
    Local uro DRE revealed significant BPH, no lumps.
    PCa Dx Aug. 2011 age of 61.
    Biopsy DXd adenocarcinoma in 3/20 cores (one 5%, two 20%). T2C.
    Gleason 3+3=6. CT abdomen, bone scan negative.
    DaVinci prostatectomy 11/1/11 at Mayo Clinic (Rochester, MN), nerve sparing, age 62.
    Surgeon was Dr. Matthew Tollefson, who I highly recommend.
    Final pathology shows tumor confined to prostate.
    5 lymph nodes, seminal vesicules, extraprostatic soft tissue all negative.
    1.0 x 0.6 x 0.6 cm mass involving right posterior inferior, right posterior apex & left
    mid posterior prostate. Right posterior apex margin involved by tumor over 0.2 cm length,
    doctor says this is insignificant.
    Prostate 98 grams, tumor 2 grams.
    Catheter out in 7 days. No incontinence, minor dripping for a few weeks.
    Eight annual post-op exams 2012 through 2019: PSA <0.1
    Semi-firm erections without "training wheels," usable erections with 100mg Sildenafil.
    NOTE: ED caused by BPH, not the surgery.

 

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