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Thread: Books on Prostate Cancer

  1. #11
    Moderator Top User HighlanderCFH's Avatar
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    Nov 2011
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    7,186
    This isn't a book, but here is a link to an interesting summary of prostate cancer & its main treatments. It is from Web MD.

    https://www.webmd.com/prostate-cance...bO9j0WnT5B8%3d
    July 2011 local PSA lab reading 6.41 (from 4.1 in 2009). Mayo Clinic PSA 9/ 2011 = 5.7.
    Local uro DRE revealed significant BPH, no lumps.
    PCa Dx Aug. 2011 age of 61.
    Biopsy DXd adenocarcinoma in 3/20 cores (one 5%, two 20%). T2C.
    Gleason 3+3=6. CT abdomen, bone scan negative.
    DaVinci prostatectomy 11/1/11 at Mayo Clinic (Rochester, MN), nerve sparing, age 62.
    Surgeon was Dr. Matthew Tollefson, who I highly recommend.
    Final pathology shows tumor confined to prostate.
    5 lymph nodes, seminal vesicules, extraprostatic soft tissue all negative.
    1.0 x 0.6 x 0.6 cm mass involving right posterior inferior, right posterior apex & left
    mid posterior prostate. Right posterior apex margin involved by tumor over 0.2 cm length,
    doctor says this is insignificant.
    Prostate 98 grams, tumor 2 grams.
    Catheter out in 7 days. No incontinence, minor dripping for a few weeks.
    Seven annual post-op exams 2012 through 2018: PSA <0.1
    Semi-firm erections without "training wheels," usable erections with 100mg Sildenafil.
    NOTE: ED caused by BPH, not the surgery.

  2. #12
    IMHO, this is useful and has good graphics. But, it was written by a family practice physician, who is neither a urologist nor a radiologist, nor an oncologist. It does not even mention SBRT, HIFU, or FLA, and it refers to vaccine (immunotherapy) as intended for advanced cases, when, in fact, active surveillance patients are being tested on it right now.

    Worthwhile, but with caveats.
    DOB: May 1944
    In Active Surveillance program at Johns Hopkins
    Strict protocol of tests, including PHI, DRE, MRI, and biopsy.
    Six biopsies from 2009 to 2019. Numbers 1, 2, and 5 were negative. Numbers 3,4, and 6 were positive with 5% Gleason(3+3) found. Last one was Precision Point transperineal.
    PSA 4.4, fPSA 24, PHI 32
    Hopefully, I can remain untreated. So far, so good.

  3. #13
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    In the literature I'm reading, I'm comeing across the terms sterols and beta-siteosterols. What I can't figure out after googling is do they effect prostate cancer cells in different ways? Or are they the same thing but from different sources? Thank you

  4. #14
    Moderator Top User HighlanderCFH's Avatar
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    Welcome to the forum, Blair.

    I'm not sure about the answer to your question. So let's see if others have some info on this over the next few days.

    Take care,
    Chuck
    July 2011 local PSA lab reading 6.41 (from 4.1 in 2009). Mayo Clinic PSA 9/ 2011 = 5.7.
    Local uro DRE revealed significant BPH, no lumps.
    PCa Dx Aug. 2011 age of 61.
    Biopsy DXd adenocarcinoma in 3/20 cores (one 5%, two 20%). T2C.
    Gleason 3+3=6. CT abdomen, bone scan negative.
    DaVinci prostatectomy 11/1/11 at Mayo Clinic (Rochester, MN), nerve sparing, age 62.
    Surgeon was Dr. Matthew Tollefson, who I highly recommend.
    Final pathology shows tumor confined to prostate.
    5 lymph nodes, seminal vesicules, extraprostatic soft tissue all negative.
    1.0 x 0.6 x 0.6 cm mass involving right posterior inferior, right posterior apex & left
    mid posterior prostate. Right posterior apex margin involved by tumor over 0.2 cm length,
    doctor says this is insignificant.
    Prostate 98 grams, tumor 2 grams.
    Catheter out in 7 days. No incontinence, minor dripping for a few weeks.
    Seven annual post-op exams 2012 through 2018: PSA <0.1
    Semi-firm erections without "training wheels," usable erections with 100mg Sildenafil.
    NOTE: ED caused by BPH, not the surgery.

  5. #15
    Quote Originally Posted by blairollie View Post
    In the literature I'm reading, I'm comeing across the terms sterols and beta-siteosterols. What I can't figure out after googling is do they effect prostate cancer cells in different ways? Or are they the same thing but from different sources? Thank you
    Blair, from what I can find, these are components widely found in plants. They are often studied along with saw palmetto as a natural aid to fight the problems from benign prostatic hypertrophy. I only found one French study that suggested they are active against prostate cancer, and that was in-vitro, and nothing else has been published since 2006. If you have prostate cancer, or are concerned about getting prostate cancer, these pills should not, IMHO, be what you should be thinking about.
    DOB: May 1944
    In Active Surveillance program at Johns Hopkins
    Strict protocol of tests, including PHI, DRE, MRI, and biopsy.
    Six biopsies from 2009 to 2019. Numbers 1, 2, and 5 were negative. Numbers 3,4, and 6 were positive with 5% Gleason(3+3) found. Last one was Precision Point transperineal.
    PSA 4.4, fPSA 24, PHI 32
    Hopefully, I can remain untreated. So far, so good.

  6. #16

    Prostate Cancer, an Online Overview [2017]

    Cancer, Prostate [Dec 2017, Full Text, 139 References, NCBI Bookshelf]

    Stephen W. Leslie1; Larry E. Siref2.
    1Creighton University Medical Center
    2Creighton University School of Medicine

    A broad online review, perhaps most of interest to newly diagnosed patients and family.

    Introduction
    Worldwide, prostate cancer is the most commonly diagnosed malignancy and the sixth leading cause of cancer death in men. In 2012, this amounted to 1,100,000 newly diagnosed cases and 307,000 deaths around the world from this disease.

    Fortunately, the majority of prostate cancers tend to grow slowly and are low-grade with relatively low risk and limited aggressiveness.

    There are no initial or early symptoms in most cases, but late symptoms may include fatigue due to anemia, bone pain and paralysis from spinal metastases, and renal failure from bilateral ureteral obstruction.

    Diagnosis is primarily based on prostate-specific antigen (PSA) testing, and transrectal ultrasound-guided (TRUS) prostate tissue biopsies, although PSA testing for screening remains controversial.

    Newer diagnostic modalities include free and total PSA levels, PCA3 urine testing, Prostate Health Index scoring (PHI), the"4K" test, genomic analysis, MRI imaging, PIRADS scoring, and MRI-TRUS fusion guided biopsies.

    When the cancer is limited to the prostate, it is considered localized and potentially curable.

    If the disease has spread to the bones or elsewhere outside the prostate, pain medications, bisphosphonates, rank ligand inhibitors, hormonal treatment, chemotherapy, radiopharmaceuticals, immunotherapy, focused radiation, and other targeted therapies can be used. Outcomes depend on age, associated health problems, tumor histology and the extent of the cancer.
    ...
    Summary

    Prostate cancer diagnosis and treatment can be complex and is often controversial. Contributing factors include:

    Unrealistic patient expectations.
    Recommendations and guidelines that seem to be changing almost daily.
    Conflicting recommendations and guidelines from the USPSTF and other professional organizations like the American Medical Association, the American Cancer Society and the American Urological Association.
    Decreased PSA screenings following the USPSTF report of 2012, a drop of 30%.
    The entire PSA testing controversy.
    Confusion about how best to use the newly available genomic tests.
    The need to better define the role and improve the diagnostic accuracy and reliability of prostatic MRI.
    Fully implementing MRI image directed biopsy technology such as MRI-TRUS fusion guidance.
    Clarifying the proper use of active surveillance and finding acceptable alternatives to mandatory repeat biopsies.
    The lack of good, minimally invasive curative therapies for localized disease that are less expensive and better tolerated than definitive radiation therapy or radical surgery.
    These and many more issues continue to challenge clinicians who deal with prostate cancer patients and men at risk for this common, potentially lethal male malignancy.
    Last edited by DjinTonic; 12-27-2017 at 02:32 PM.
    69 yr at Dx, BPH x 20 yr, 9 (!) neg. Bx, PCA3 -
    2013 TURP (90→30 g) path neg. then 6-mo. checks
    6-06-17 Nodule on R + PSA rise on finasteride: 3.6→4.3
    6-28-17 Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM
    Bone scan, CTs, X-rays: neg.
    8-7-17 Open RP, neg. frozen sections, Duke Regional
    SM EPE BNI LVI SVI LNI(16): negative, PNI+, nerves spared
    pT2c pN0 pMX acinar adenocarcinoma G9 (4+5) 5% of prostate (4.5x5x4 cm, 64 g)
    11-10-17 Decipher 0.37 Low Risk: 5-yr met risk 2.4%, 10-yr PCa-specific mortality 3.3%
    Dry; ED OK with sildenafil
    9-16-17 (5 wk) PSA <0.1
    LabCorp uPSA, Roche ECLIA:
    11-28-17 (3 m ) 0.010
    02-26-18 (6 m ) 0.009
    05-30-18 (9 m ) 0.007
    08-27-18 (1 yr.) 0.018 (?)
    09-26-18 (13 m) 0.013 (30-day check)
    11-26-18 (15 m) 0.012
    02-25-19 (18 m) 0.015
    05-22-19 (21 m) 0.015

  7. #17
    Top User garyi's Avatar
    Join Date
    Apr 2017
    Posts
    1,293
    Prostate cancer diagnosis and treatment can be complex and is often controversial. Contributing factors include:

    Unrealistic patient expectations.
    Recommendations and guidelines that seem to be changing almost daily.
    Conflicting recommendations and guidelines from the USPSTF and other professional organizations like the American Medical Association, the American Cancer Society and the American Urological Association.
    Decreased PSA screenings following the USPSTF report of 2012, a drop of 30%.
    The entire PSA testing controversy.
    Confusion about how best to use the newly available genomic tests.
    The need to better define the role and improve the diagnostic accuracy and reliability of prostatic MRI.
    Fully implementing MRI image directed biopsy technology such as MRI-TRUS fusion guidance.
    Clarifying the proper use of active surveillance and finding acceptable alternatives to mandatory repeat biopsies.
    The lack of good, minimally invasive curative therapies for localized disease that are less expensive and better tolerated than definitive radiation therapy or radical surgery.
    These and many more issues continue to challenge clinicians who deal with prostate cancer patients and men at risk for this common, potentially lethal male malignancy.

    ...............is that all?
    72...LUTS for the past 7 years
    TURP 2/16,
    G3+4 discovered
    3T MRI 5/16
    MRI fusion guided biopsy 6/16
    14 cores; four G 3+3, one G3+4,
    CIPRO antibiotic = C. Diff infection 7/16
    Cured with Vanco for 14 days
    Second 3T MRI 1/17
    Worsened bulging of posterior capsule
    Oncotype DX GPS 3/17, LFP risk 63%, Likelihood of Low
    Grade Disease 81%, Likelihood of Organ Confined 80%
    RALP 7/13/17 Dr. Gonzaglo @ Univ of Miami
    G3+4 Confirmed, Organ confined
    pT2 pNO pMn/a Grade Group 2
    PSA 0.32 to .54 over 3 months
    DCFPyl PET & ercMRI Scans - 11/17
    A one inch tumor still in prostate bed = failed surgery
    All met scans clear
    SRT, 2ADT, IMGT 70.2 Gys @1.8 per, completed 5/18
    Radiation Procitis, and Ulcerative Colitis flaired after 20 years
    PSA <.006 9/18, .054 11/18, .070 12/18, .067 2/19, .078 5/19, .074 7/19
    We'll see....what is not known dwarfs what is thought to be fact

  8. #18
    Release date of the new edition of Dr. Patrick Walsh's Guide to Surviving Prostate Cancer?

    At Amazon I was trying, without success, to find the publication date of the new edition of Walsh's book. I was finally able to generate a search that got me to this page, which, although it pictures the current (3rd) edition, has a release date of May 15, 2018 and a pre-order (paper) price of $20.99. So I'm assuming this is the new 4th edition. (The current 3rd edition is $11.90 in paper at Amazon.)

    Djin
    Last edited by DjinTonic; 12-29-2017 at 09:39 AM.
    69 yr at Dx, BPH x 20 yr, 9 (!) neg. Bx, PCA3 -
    2013 TURP (90→30 g) path neg. then 6-mo. checks
    6-06-17 Nodule on R + PSA rise on finasteride: 3.6→4.3
    6-28-17 Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM
    Bone scan, CTs, X-rays: neg.
    8-7-17 Open RP, neg. frozen sections, Duke Regional
    SM EPE BNI LVI SVI LNI(16): negative, PNI+, nerves spared
    pT2c pN0 pMX acinar adenocarcinoma G9 (4+5) 5% of prostate (4.5x5x4 cm, 64 g)
    11-10-17 Decipher 0.37 Low Risk: 5-yr met risk 2.4%, 10-yr PCa-specific mortality 3.3%
    Dry; ED OK with sildenafil
    9-16-17 (5 wk) PSA <0.1
    LabCorp uPSA, Roche ECLIA:
    11-28-17 (3 m ) 0.010
    02-26-18 (6 m ) 0.009
    05-30-18 (9 m ) 0.007
    08-27-18 (1 yr.) 0.018 (?)
    09-26-18 (13 m) 0.013 (30-day check)
    11-26-18 (15 m) 0.012
    02-25-19 (18 m) 0.015
    05-22-19 (21 m) 0.015

  9. #19
    Moderator Top User HighlanderCFH's Avatar
    Join Date
    Nov 2011
    Posts
    7,186
    Thanks for this info, Djin.
    July 2011 local PSA lab reading 6.41 (from 4.1 in 2009). Mayo Clinic PSA 9/ 2011 = 5.7.
    Local uro DRE revealed significant BPH, no lumps.
    PCa Dx Aug. 2011 age of 61.
    Biopsy DXd adenocarcinoma in 3/20 cores (one 5%, two 20%). T2C.
    Gleason 3+3=6. CT abdomen, bone scan negative.
    DaVinci prostatectomy 11/1/11 at Mayo Clinic (Rochester, MN), nerve sparing, age 62.
    Surgeon was Dr. Matthew Tollefson, who I highly recommend.
    Final pathology shows tumor confined to prostate.
    5 lymph nodes, seminal vesicules, extraprostatic soft tissue all negative.
    1.0 x 0.6 x 0.6 cm mass involving right posterior inferior, right posterior apex & left
    mid posterior prostate. Right posterior apex margin involved by tumor over 0.2 cm length,
    doctor says this is insignificant.
    Prostate 98 grams, tumor 2 grams.
    Catheter out in 7 days. No incontinence, minor dripping for a few weeks.
    Seven annual post-op exams 2012 through 2018: PSA <0.1
    Semi-firm erections without "training wheels," usable erections with 100mg Sildenafil.
    NOTE: ED caused by BPH, not the surgery.

  10. #20
    Top User garyi's Avatar
    Join Date
    Apr 2017
    Posts
    1,293
    That, more or less, matches what I was told, Djin.

    Release of 4th edition ~ the end of the first quarter, 2018.
    72...LUTS for the past 7 years
    TURP 2/16,
    G3+4 discovered
    3T MRI 5/16
    MRI fusion guided biopsy 6/16
    14 cores; four G 3+3, one G3+4,
    CIPRO antibiotic = C. Diff infection 7/16
    Cured with Vanco for 14 days
    Second 3T MRI 1/17
    Worsened bulging of posterior capsule
    Oncotype DX GPS 3/17, LFP risk 63%, Likelihood of Low
    Grade Disease 81%, Likelihood of Organ Confined 80%
    RALP 7/13/17 Dr. Gonzaglo @ Univ of Miami
    G3+4 Confirmed, Organ confined
    pT2 pNO pMn/a Grade Group 2
    PSA 0.32 to .54 over 3 months
    DCFPyl PET & ercMRI Scans - 11/17
    A one inch tumor still in prostate bed = failed surgery
    All met scans clear
    SRT, 2ADT, IMGT 70.2 Gys @1.8 per, completed 5/18
    Radiation Procitis, and Ulcerative Colitis flaired after 20 years
    PSA <.006 9/18, .054 11/18, .070 12/18, .067 2/19, .078 5/19, .074 7/19
    We'll see....what is not known dwarfs what is thought to be fact

 

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