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Thread: anti-mesothelin trials. 90 to 100% PC express mesothelin

  1. #1
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    anti-mesothelin trials. 90 to 100% PC express mesothelin

    More than 90% of pancreatic cancers express mesothelin. Several antibodies are developed that target cells expressing mesothelin and they are tested in clinical trials. E.g.
    https://clinicaltrials.gov/ct2/show/NCT02810418 Mesothelin-Targeted Immunotoxin LMB-100 Alone or in Combination With Nab-Paclitaxel in People With Previously Treated Metastatic and/or Locally Advanced Pancreatic Ductal Adenocarcinoma and Mesothelin Expressing Solid Tumors.
    66y female, dx @43 in 1992 - DLBCL (aggressive lymphoma) CHOP x 6, rads x 20. 2007- Follicular Lymphoma (FL) grade1-2, stage 2, rads x 20. 2013 relapsed FL, grade 1-2, stage 4. R-bendamustine x 6. Finished Jan 2015. Rituxan maintenance till 2017. 11/2014 bladder cancer, surgery end of Jan 2015.

  2. #2
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    Alberta, Canada
    Posts
    400
    Another trial for mesothelin expressing PanCan https://clinicaltrials.gov/ct2/show/NCT03023722 Phase II Anetumab Ravtansine in Pre-treated Mesothelin-expressing Pancreatic Cancer.
    66y female, dx @43 in 1992 - DLBCL (aggressive lymphoma) CHOP x 6, rads x 20. 2007- Follicular Lymphoma (FL) grade1-2, stage 2, rads x 20. 2013 relapsed FL, grade 1-2, stage 4. R-bendamustine x 6. Finished Jan 2015. Rituxan maintenance till 2017. 11/2014 bladder cancer, surgery end of Jan 2015.

 

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