A website to provide support for people who have or have had any type of cancer, for their caregivers and for their family members.
Results 1 to 4 of 4

Thread: Why I Chose Immunotherapy for PanCan

  1. #1
    Super Moderator Top User ddessert's Avatar
    Join Date
    Oct 2013
    Posts
    2,239
    Blog Entries
    7

    Why I Chose Immunotherapy for PanCan

    FORCE, a hereditary cancer organization that I volunteer for, has published a blog posting of mine on why I chose an immunotherapy treatment for my pancreatic cancer.

    David

    http://www.facingourrisk.org/get-involved/HBOC-community/BRCA-HBOC-blogs/FORCE/research/chose-immunotherapy-pancreatic-cancer/
    BRCA2 3398del5
    Dec 2010 - back/abd pain
    May 2011 - Unresectable stage III, 2.5cm tumor
    Jun-Aug 2011 - Gem/Cis, 9 rounds
    Oct-Nov 2011 - Radiation+Xeloda, 25 days in 5 weeks
    Oct 2011-Sep 2012 - shrinking tumor
    Feb 2012 - National Familial Pancreatic Study
    Aug 2012 - Downgraded to stage IIA, PGP
    Sep 2012 - Whipple, T3N0M0, 0.5cm tumor, 0/16 lymph nodes
    Dec 2012 - Quebec PanCan Study
    Sep 2012-May 2018 - NED
    Mar 2013-present - NCT01088789
    @pancanology

  2. #2
    Experienced User Dand's Avatar
    Join Date
    Jul 2016
    Posts
    95
    David just read your blog posting... keep sharing your knowledge helping all of us past, present, future & adding many more NED years to your signature.
    BRCA2 Positive
    7/26/16-CT Scan with Liver Biopsy diagnosis Stage IV Pancreatic Cancer + metastatic of liver.
    8/2/16-Clinical Trial Cisplatin/Gemcitabine + Veliparib
    8/15/16- CA 19-9=37,750 U/mL/CEA 126.5 ng/mL
    9/05/16- CA 19-9=19,778 U/mL/CEA 74.9 ng/mL
    9/21/16- CT Scan -13.10% down from Bl (SD)
    9/26/16- CA 19-9=24,528 U/mL/CEA 61.3 ng/mL
    10/17/16- CA 19-9=24,792 U/mL/CEA 42.9 ng/mL
    11/2/16-CT Scan -22.30% down from Bl
    11/07/16- CA 19-9=24,895 U/mL/CEA 30.2 ng/mL
    12/09/16- IR VA Power Port
    12/14/16-CT Scan -26.20% down SD)
    12/19/16- ???? Skipping because of word limitations
    4/3/17- CT Scan -41.50% down (SD) (PR)
    5/24/17- CA 19-9=1,934 U/mL/CEA 10 ng/mL
    6/5/17-CT Scan -50% down (PR)
    6/19/17- Stage II Trial Mono Veliparib
    7/17/17- CA 19-9=1,336 U/mL/CEA 9.1 ng/mL
    8/6/17-CT Scan -65% down (PR) no new sites
    11/20/17- CA 19-9=380 U/mL/CEA 7.6 ng/mL
    1/1/18- CA 19-9=304
    4/22/18 CA 19-9=182 U/mL/CEA 6.5 ng/mL
    7/13/18-CT Scan -80% down (SD)

  3. #3
    Moderator Senior User IndyLou's Avatar
    Join Date
    Jan 2014
    Posts
    381
    Hello, David. What a fascinating and educational read...congrats on your publication, and on your success in being treated for pancreatic cancer!

    I've read with some interest, that there's a school of thought that suggests that immunotherapy drugs may not be needed to be given to patients indefinitely. The thinking is that once these drugs "prime" it, the immune system will continue to work as it should. There was even talk of designing randomized clinical trials to take patients off treatment at certain intervals; e.g., 2 months, 6 months, 12 months, etc. Do you think it's possible that your treatment would continue to work if you were taken off it?

    In any case, thanks again for sharing your blog. Best wishes!
    Age 52 Male
    early Feb, 2013 - Noticed almond-sized lump in shaving area, right side of neck. No other "classic" cancer symptoms
    late Feb, 2013 - Visited PCP for check-up, PCP advised as lymphoma. Did blood work, orders for CT-scan, referred to ENT
    3/7/13 - CT-scan inconclusive, endoscopy negative
    3/9/13 - FNA of neck mass
    3/14/13 - Received dx of squamous-cell carcinoma, unknown primary
    3/25/13 - CT-PET scan reveals no other active tumors
    3/26/13 - work/up for IMRT
    4/1/13 - W1, D1 of weekly cetuximab
    4/8/13 - W1, D1 of IMRT
    5/20/13 - complete 8 week regimen of weekly cetuximab
    5/24/13 - Complete 35-day regimen of daily IMRT
    mid-July 2013 - CT-PET scan reveals no active tumors, but shows necrotic tissue at site of original tumor
    early Sept 2013 - partial neck dissection to remove necrotic tissue. Assay shows no cancer present.
    Spring 2014 - No signs of cancer
    Spring 2015 - NED
    Spring 2016 - NED
    Spring 2017 - NED
    Spring 2018 - NED

  4. #4
    Super Moderator Top User ddessert's Avatar
    Join Date
    Oct 2013
    Posts
    2,239
    Blog Entries
    7
    Hi IndyLou,

    I think the longevity of this vaccine is something they may be looking at. They’ve purposefully set up the trial for boost shots every 6 months for 10 years.

    As you know, exposures to some diseases gives us life-long immunity to that disease. But for others, like the seasonal flu, we get shots every year that often cover the same strains because the protection declines over time.

    I have noticed that my body seems to react and recover more quickly from subsequent vaccine shots. The initial one(s) gave me a more prolonged reaction. That’s one indicator that it’s still providing some protection after 6 months.

    The pancreas G-VAX vaccine shots contain irradiated pancreas cancer cells that have genetically modified GM-CSF proteins. These GM-CSF proteins are (hopefully) recognized by the immune system as foreign invaders and wiped out.

    I suspect that as the body’s immune system is dismantling and destroying these cells, it may look through the other proteins inside and see some that others look foreign as well. If my cancer cells also contain GM-CSF or some of these other ‘foreign proteins’, they may take on my cancer cells as well.

    It’s hard to know which pathway of destruction is working and it may be different for each patient. So the longevity of the vaccine protection may also vary between patients.

    I guess by giving everyone boost shots every 6 months for 10 years, they bypass the possibility of short-lasting protection and can concentrate on the efficacy of the treatment no matter how long it lasts.

    But they’re also taking about a pint of blood a month after the shots to look at what immune cells are still circulating around. It’s kind of a pain to go to Quest and have them draw 28 tubes of blood and FedEx the package to Johns Hopkins. I try to go to the same one each time.
    BRCA2 3398del5
    Dec 2010 - back/abd pain
    May 2011 - Unresectable stage III, 2.5cm tumor
    Jun-Aug 2011 - Gem/Cis, 9 rounds
    Oct-Nov 2011 - Radiation+Xeloda, 25 days in 5 weeks
    Oct 2011-Sep 2012 - shrinking tumor
    Feb 2012 - National Familial Pancreatic Study
    Aug 2012 - Downgraded to stage IIA, PGP
    Sep 2012 - Whipple, T3N0M0, 0.5cm tumor, 0/16 lymph nodes
    Dec 2012 - Quebec PanCan Study
    Sep 2012-May 2018 - NED
    Mar 2013-present - NCT01088789
    @pancanology

 

Similar Threads

  1. Survey results from low risk patients who chose RP, RT, and AS
    By ASAdvocate in forum Prostate Cancer Forum
    Replies: 3
    Last Post: 03-15-2016, 12:58 PM
  2. Smelly gas - why why why?
    By Lisa Renee in forum Pancreatic Cancer Forum
    Replies: 12
    Last Post: 09-02-2015, 03:35 PM
  3. PCa and Protons....Why I chose RALP
    By DriscollOFD in forum Prostate Cancer Forum
    Replies: 3
    Last Post: 01-31-2015, 01:43 AM
  4. has anybody chose the wait and watch medtod and for how long
    By 240garth in forum Prostate Cancer Forum
    Replies: 7
    Last Post: 08-08-2010, 05:12 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •