A website to provide support for people who have or have had any type of cancer, for their caregivers and for their family members.
Results 1 to 4 of 4

Thread: Gut bacteria may affect pancreatic cancer

  1. #1

    Gut bacteria may affect pancreatic cancer

    https://www.sciencedaily.com/release...0322103236.htm

    Gut bacteria may affect pancreatic cancer.

    Specifically, the study found that removing bacteria from the gut and pancreas by treating mice with antibiotics slowed cancer growth and reprogrammed immune cells to again "take notice" of cancer cells. Oral antibiotics also increased roughly threefold the efficacy of checkpoint inhibitors, a form of immunotherapy that had previously failed in pancreatic cancer clinical trials, to bring about a strong anti-tumor shift in immunity
    Last edited by lancepeace; 10-14-2018 at 12:50 PM.

  2. #2
    Moderator Senior User BrigitteM's Avatar
    Join Date
    Sep 2016
    Posts
    345
    Wow! I hope these findings are confirmed.... Treating pancreatic cancer by adding a few antibiotics into the treatment cocktail, that would be so easy!
    __________________________________________________ ___________________
    1/12/2016 No symptoms except ongoing fatigue; blood test revealed elevated liver enzymes
    1/18/2016 Liver ultrasound, then MRI confirmed enlarged bile duct
    1/21/2016 ERCP and placement of a temporary stent
    1/28/2016 CT-Scan showed a lesion on the head of pancreas
    2/09/2016 2nd ERCP + EUS + FNA
    2/12/2016 DX Borderline resectable pancreas ductal adenocarcinoma - Stage 3 @ 61
    2/24/2016 FOLFIRINOX 3 cycles (6 infusions)
    5/12/2016 CYBER-KNIFE Stereotactic Radiation 3 sessions
    6/16/2016 WHIPPLE + portal vein and right hepatic artery reconstructions - 0/19 nodes pos - no mets. Restaged to 1A
    8/31/2016 FOLFOX for 3 cycles (6 infusions)
    Sept 2016 Know Your Tumor - PANCAN.org
    11/4/2016 CT Scan clear - NED
    May 2017 Liver lesion - DX mild fatty liver disease - NED
    Aug 2017 Several tiny lung nodules - NED
    Feb 2018 Stable lung nodules - NED
    May 2018. Lung nodules are growing; possibly mets, but still considered NED
    Aug 2018 One lung nodule has reached 1.7 cm. Pancreatic metastasis confirmed by biopsy.
    Sept 2018 Starting clinical trial with RX-3117 and Abraxane (NCT03189914)
    Nov 2028 CT-scan: Lung nodules are shrinking

  3. #3
    Reporting in the Journal of Clinical Investigation Insights, a team led by senior author Andrea Facciabene, PhD, a research assistant professor of Radiation Oncology and Obstetrics/Gynecology, found that the effectiveness of adoptive T cell therapy (ACT) in mice with cancer is significantly affected by differences in the natural makeup of gut bacteria and treatment with antibiotics. The team also found that the use of fecal transplants -- which are increasingly used for treating recurrent C. difficile colitis -- affected the efficacy of ACT between different strains of lab rodents. ACT enlists a patient's own immune system to fight diseases, such as cancer and certain infections. T cells are collected from a patient and grown in the lab to increase the number of tumor-killing T cells. . The pumped-up cells are then given back to the patient as reinforcements to the body's natural anti-tumor immune response.


    https://www.sciencedaily.com/release...0402171038.htm
    Last edited by lancepeace; 10-14-2018 at 12:54 PM. Reason: fix link

  4. #4
    Senior User
    Join Date
    Mar 2018
    Posts
    100
    Derek Lowe (always a good read) has a couple of blogs about this worth reading. Here is a link to one - especially noticed by me - pancreatic patient being treated with a Gemcitabine combination therapy. So far my oncologist does not see the need, and I hear some think that doing antibiotics will strip needed gut bacteria. Wish I knew the answer.

    http://blogs.sciencemag.org/pipeline...e-tumors-worse
    Mar. '18 - Diagnosed Stage IV with liver mets CA-19 124,000
    Apr. '18 - Started chemo - Gem, Abrx, Cis
    July and Sept '18 - Ct scan - all tumors shrinking
    Oct. '18 - CA-19 - 1,495
    Oct. '18 - Started Gem, Abrx 1/2 dose

 

Similar Threads

  1. A punch to the gut
    By Joe1 in forum Worried About Possible Cancer
    Replies: 5
    Last Post: 11-08-2015, 03:41 AM
  2. Awaiting Biopsy Results...The Panic Monsters in my Gut!!!
    By frustratednik in forum Lymphoma - Hodgkin's and Non-Hodgkin's Lymphoma Forum
    Replies: 10
    Last Post: 11-08-2015, 12:34 AM
  3. Replies: 0
    Last Post: 07-08-2005, 04:00 AM
  4. Replies: 0
    Last Post: 05-23-2005, 04:00 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •