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Thread: Ca125 high before chemo

  1. #1
    Newbie New User
    Join Date
    Dec 2018

    Ca125 high before chemo

    Hello, mother was diagnosed beginning of November with ovarian cancer stage 3b with ca125 3800, surgery after 2 weeks considered optimal debulking ca125 went down to 390. She is starting chemo therapy today both ip and iv, and they ran another ca125 showing now 2000. The doctor seemed concerned about that , as well as confused why it jumped so much in such a short time . Now has anyone experienced the same ? Or could the big jump be due to something else in addition to her diagnosis? Please share

  2. #2
    Moderator Top User jorola's Avatar
    Join Date
    May 2014
    Hello Telep81,
    While I have no had personal experiences with this I can offer you this from the Mayo Clinic:

    "If you've been diagnosed with ovarian, endometrial, peritoneal or fallopian tube cancer, a decreasing CA 125 level often indicates that the cancer is responding to treatment. A rising CA 125 level may indicate a return or continued growth of the cancer.

    A number of normal and noncancerous conditions can cause an elevated CA 125 level, including:

    Liver disease
    Pelvic inflammatory disease
    Uterine fibroids

    None of the major professional organizations recommend using the CA125 as a screening test for those with an average risk of ovarian cancer."

    The best thing is for your mom to follow up with her doctors regarding this concern as they are treating her and have the ful information as to what is going on and most importantly are the medical experts.

    All the best to your Mom in treatment and you as a caregiver as well.

    Wife to husband with squamous lung cancer stage 3 b
    dx - April 20/14
    tx started May 20/14 - radiation and chemo
    June 23 - chemo finished
    July 4 - radiation finished
    July 8 - PET scan shows tumor almost gone, lymph nodes back to normal
    Married July 19/14
    Sept 9/14 - repeat can shows tumor continues to shrink more, no new spots. New coughing and pain due to chest infection or side effect of radiation.
    Sept 19/14 - not infection but pneumonitis, place on dex for 4 weeks
    Oct 22/14 - now off of dex and facing even more symptoms of withdrawal
    Dec 16/14 - pretty much nothing left but a scar
    April 7/15 - ditto scan and screw you stats
    Oct 6/15 - more scarring but still cancer still gone
    Feb 2016 -scan the same
    Aug 2016 - more of the same
    Aug 2017 - and ditto
    Aug 2018 - 4 yrs NED - no evidence of disease
    Aug 2019 - 5 yrs NED and discharged from cancer clinic!!!!!


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