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Thread: MRI Prostate Screening for High-Risk men

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    Super Moderator Top User ddessert's Avatar
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    MRI Prostate Screening for High-Risk men

    The National Institutes of Health has a clinical trial for men at high genetic risk for prostate cancer. This is trial is for men without prostate cancer, ages 30 to 70, who have tested positive for BRCA1, BRCA2, Lynch Syndrome (MLH1, MSH2, MSH6, PMS2, and EPCAM), HOXB13, ATM, NBN, TP53 CHEK2, PALB2, RAD51D, or FANCA. The trial involves screening MRI of the prostate every two years and biopsy of the prostate if the MRI is abnormal.

    There is no cost for travel or study-related tests.

    For more details and contact information, please contact Anna Couvillon, NP at [email protected], (240) 858-3148, and/or go to NCT03805919.
    BRCA2 3398del5
    Dec 2010 - back/abd pain
    May 2011 - Unresectable stage III, 2.5cm tumor
    Jun-Aug 2011 - Gem/Cis, 9 rounds
    Oct-Nov 2011 - IMRT+Xeloda
    Oct 2011-Sep 2012 - shrinking tumor
    Feb 2012 - National Familial Pancreatic Study
    Aug 2012 - Downgraded to stage IIA, PGP
    Sep 2012 - Whipple, T3N0M0, 0.5cm tumor, 0/16 lymph nodes
    Dec 2012 - Quebec PanCan Study
    Sep 2012-May 2019 - NED
    Mar 2013-present - NCT01088789
    Jun 2019- NCT03805919
    @pancanology

  2. #2
    Super Moderator Top User ddessert's Avatar
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    I joined this trial and had the physical exam and MRI yesterday. The trial nurse informed me that 5 of the first 9 screened had PIRADS scores of 3 or higher, indicating the need for a biopsy, which is also provided under the study for free.

    The biopsy rate is unexpectedly high and they are considering adding a control arm of men without those mutations.
    BRCA2 3398del5
    Dec 2010 - back/abd pain
    May 2011 - Unresectable stage III, 2.5cm tumor
    Jun-Aug 2011 - Gem/Cis, 9 rounds
    Oct-Nov 2011 - IMRT+Xeloda
    Oct 2011-Sep 2012 - shrinking tumor
    Feb 2012 - National Familial Pancreatic Study
    Aug 2012 - Downgraded to stage IIA, PGP
    Sep 2012 - Whipple, T3N0M0, 0.5cm tumor, 0/16 lymph nodes
    Dec 2012 - Quebec PanCan Study
    Sep 2012-May 2019 - NED
    Mar 2013-present - NCT01088789
    Jun 2019- NCT03805919
    @pancanology

 

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