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Thread: Need advice on what to expect when PSA levels go up after Salvage Radiation Therapy.

  1. #11
    Newbie New User
    Join Date
    May 2019
    Posts
    8
    Excellent information, thanks a million.
    DOB 09/24/1961
    RP 06/30/2010 PSA 7.8 before surgery, PSA <0.10 post
    Path report:
    Gleason score 3+4=7
    Grade pT3a
    Positive margin at apex
    15% tumor involvement
    6 lymph nodes examined all neg.
    Seminal vesicles neg.
    Microscopic bladder neck invasion.

    PSA gradually increased to 0.07
    2016 SRT attempted
    PSA dropped to undetectable post SRT. (<0.01)
    05/2019 PSA at 0.03

  2. #12
    Top User garyi's Avatar
    Join Date
    Apr 2017
    Posts
    1,347
    Look at my numbers, doug....you're a long way off from having to worry about your microscopic reading. That PSA can creep up for a while, and then level off.

    Not to worry....cause it doesn't help. Enjoy the weekend!
    72...LUTS for the past 7 years
    TURP 2/16,
    G3+4 discovered
    3T MRI 5/16
    MRI fusion guided biopsy 6/16
    14 cores; four G 3+3, one G3+4,
    CIPRO antibiotic = C. Diff infection 7/16
    Cured with Vanco for 14 days
    Second 3T MRI 1/17
    Worsened bulging of posterior capsule
    Oncotype DX GPS 3/17, LFP risk 63%, Likelihood of Low
    Grade Disease 81%, Likelihood of Organ Confined 80%
    RALP 7/13/17 Dr. Gonzaglo @ Univ of Miami
    G3+4 Confirmed, Organ confined
    pT2 pNO pMn/a Grade Group 2
    PSA 0.32 to .54 over 3 months
    DCFPyl PET & ercMRI Scans - 11/17
    A one inch tumor still in prostate bed = failed surgery
    All met scans clear
    SRT, 2ADT, IMGT 70.2 Gys @1.8 per, completed 5/18
    Radiation Procitis, and Ulcerative Colitis flaired after 20 years
    PSA <.006 9/18, .054 11/18, .070 12/18, .067 2/19, .078 5/19, .074 7/19, .081 9/19
    We'll see....what is not known dwarfs what is thought to be fact

  3. #13
    Newbie New User
    Join Date
    May 2019
    Posts
    8

    Question

    I read on the Social Security website that recurrent prostate cancer makes you eligible for disability. Has anyone here tried to to apply?
    DOB 09/24/1961
    RP 06/30/2010 PSA 7.8 before surgery, PSA <0.10 post
    Path report:
    Gleason score 3+4=7
    Grade pT3a
    Positive margin at apex
    15% tumor involvement
    6 lymph nodes examined all neg.
    Seminal vesicles neg.
    Microscopic bladder neck invasion.

    PSA gradually increased to 0.07
    2016 SRT attempted
    PSA dropped to undetectable post SRT. (<0.01)
    05/2019 PSA at 0.03

  4. #14
    At .03, the median lead time to official BCR is 18 months.
    YOB 1957

    DX 12/18, GS 8, 4+4 6/12 cores, LL Apex 100%, LM Apex 60%, LL Mid 50%, LMM 40%, LL Base 5%, LM <5%, Right side negative.

    2/25/19 Robotic Laparoendoscopic Single Site Surgery outpatient Cleveland Clinic,

    3/6/19. Pathology - Grade Group 4 with Intraductal Carcinoma
    T3aNO, GS8, 21 mm unifocal tumor 10%. -7 Nodes, - SV, - Margins, - PNI,
    - bladder neck neg., +LVI, + EPE non focal apex/mid lateral 1mm max extension, Cribriform pattern present. Decipher .86 High Risk.

    PSA 3/27/19 .03. (29 days)
    4/25/19 <.03. (58 days)
    5/25/19 <.02. (88 days)
    9/10/2019. <.02. (198 days)

    ADT - 6/19 - 6/21
    ART - 8/19 - 9/19. (78 Gy, yes, I glow in the dark)

  5. #15
    (deleted....)

  6. #16
    Senior User
    Join Date
    Mar 2017
    Posts
    105
    Dougbla, I am right there now. RP went 1 year 2 months undetectable,PSA came back at .4 did trial study found BCR did SRT (42) Did ADT 2 years 1 month PSA up to .258 waiting Pet Scan w/Axumin MO says ADT working correctly just some Ca not responding. Will know more in 10 days. Believe me it gets easier each time after the first BCR! I knew it was going to be new drugs after each failed. This is what they do to prolong your life. Reason why they ussally say something else will kill you! This is based on starting in your 70's they can get 15 years? I started at 56 I'm hoping for as many as I can get...
    steve
    Diag. 56 DOB 2/59 PSA 01/14 (2.0) 6/15/15 (2.4)
    Biopsy 6/23/15 5 Gleason Score 8
    Pet Scan & Biopsy of rib Neg
    RP 10/15/15
    Path 54g 5x4.2x2.8cm 4+3=7 Tumor location quadrants Bilateral
    Extra-capsular extensions present,Semi vesicles no invasion
    Vascular invasion none, Perineural invasion identified ,Multicentricity : multifocal
    Margins involvement/Not present on inked margins lymph nodes : five negative pT3a,N0
    PSA 10/6/16 .1 1yr PSA 02/02/17 .4 PSA 02/15/17 .5
    Pet Scan 2/18/17 Neg
    PSA 03/17 .6
    03/17 Axumin trial 17.4mm recurrence rt. semi vascular bed
    03/17 Casodex + Trelstar 2yrs Casodex stopped 6/18 7/19 Trestar+Xtandi + Zoledronic Acid
    04/17 SRT (42) completed 6/3/17
    08/31/2017 PSA < .1 Last 6 uPSA <.006 uPSA 2/19 <.030 2nd BCR 5/19 <.235 5/19 <3.2 6/19 <.34 7/19 <.06
    06/10/2019 Pet w/Axumin inconclusive. Looking at Cyberknife for two possible bone Matastisis

  7. #17
    Newbie New User
    Join Date
    May 2019
    Posts
    8

    Iím with ya brother.

    Quote Originally Posted by steve135 View Post
    Dougbla, I am right there now. RP went 1 year 2 months undetectable,PSA came back at .4 did trial study found BCR did SRT (42) Did ADT 2 years 1 month PSA up to .258 waiting Pet Scan w/Axumin MO says ADT working correctly just some Ca not responding. Will know more in 10 days. Believe me it gets easier each time after the first BCR! I knew it was going to be new drugs after each failed. This is what they do to prolong your life. Reason why they ussally say something else will kill you! This is based on starting in your 70's they can get 15 years? I started at 56 I'm hoping for as many as I can get...
    steve
    Went in to the lab today to get my blood drawn for my follow up PSA test. So now I wait, wondering which road Iíll be going down from here on........Iím 57, Iíve had this cancer for nine years hanging over my head. Most times I forget about it and early in I told myself I was probably cured. Then it came back three years ago. I was told it was at a very low level (PSA) but I could start my SRT and likely take care of it, so I did. Nope, came back again. I have read many NIH studies that love to boast of the 10 year survival rates......well, that gets me to 67. Whooopie.
    DOB 09/24/1961
    RP 06/30/2010 PSA 7.8 before surgery, PSA <0.10 post
    Path report:
    Gleason score 3+4=7
    Grade pT3a
    Positive margin at apex
    15% tumor involvement
    6 lymph nodes examined all neg.
    Seminal vesicles neg.
    Microscopic bladder neck invasion.

    PSA gradually increased to 0.07
    2016 SRT attempted
    PSA dropped to undetectable post SRT. (<0.01)
    05/2019 PSA at 0.03

  8. #18
    Good luck Dougbla! Fingers crossed for a favorable result.

    As Tom Petty once crooned: "The waiting is the hardest part!"

    Remain confident and calm & send us an update.

    MF
    Last edited by Michael F; 08-14-2019 at 03:41 PM.

  9. #19
    Newbie New User
    Join Date
    May 2019
    Posts
    8

    Cool Undetectable......again!

    Quote Originally Posted by Michael F View Post
    Good luck Dougbla! Fingers crossed for a favorable result.

    As Tom Petty once crooned: "The waiting is the hardest part!"

    Remain confident and calm & send us an update.

    MF
    The results are back and itís back to undetectable! <0.01 ng/mL
    I see my Urologist Tuesday. I have never had a reading go down like this, Iím hoping the doc tells me the last reading was an anomaly, feeling soooooo relieved at the moment.
    DOB 09/24/1961
    RP 06/30/2010 PSA 7.8 before surgery, PSA <0.10 post
    Path report:
    Gleason score 3+4=7
    Grade pT3a
    Positive margin at apex
    15% tumor involvement
    6 lymph nodes examined all neg.
    Seminal vesicles neg.
    Microscopic bladder neck invasion.

    PSA gradually increased to 0.07
    2016 SRT attempted
    PSA dropped to undetectable post SRT. (<0.01)
    05/2019 PSA at 0.03

  10. #20
    Quote Originally Posted by Dougbla View Post
    The results are back and it’s back to undetectable! <0.01 ng/mL
    I see my Urologist Tuesday. I have never had a reading go down like this, I’m hoping the doc tells me the last reading was an anomaly, feeling soooooo relieved at the moment.
    Good deal.
    YOB 1957

    DX 12/18, GS 8, 4+4 6/12 cores, LL Apex 100%, LM Apex 60%, LL Mid 50%, LMM 40%, LL Base 5%, LM <5%, Right side negative.

    2/25/19 Robotic Laparoendoscopic Single Site Surgery outpatient Cleveland Clinic,

    3/6/19. Pathology - Grade Group 4 with Intraductal Carcinoma
    T3aNO, GS8, 21 mm unifocal tumor 10%. -7 Nodes, - SV, - Margins, - PNI,
    - bladder neck neg., +LVI, + EPE non focal apex/mid lateral 1mm max extension, Cribriform pattern present. Decipher .86 High Risk.

    PSA 3/27/19 .03. (29 days)
    4/25/19 <.03. (58 days)
    5/25/19 <.02. (88 days)
    9/10/2019. <.02. (198 days)

    ADT - 6/19 - 6/21
    ART - 8/19 - 9/19. (78 Gy, yes, I glow in the dark)

 

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