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Thread: Endonmetroid cell grade 3 cancer

  1. #1
    Newbie New User
    Join Date
    Jun 2019

    Endonmetroid cell grade 3 cancer

    Best health wishes to everyone on this forum.
    Passing blood, was first worry, no other pain issues, as cramps, pelvic pain, etc. BUT my knee became very sore and painful to the point
    I could not walk up or down steps, so went got a cane to help. Went had xrays and such, given pain killers to help, which not strong enough, etc'

    The blood kept leaking , some days none, like every other day, so went see gyn, he found polyp on cervix, then did biopsy, found cell grade 3 he told me cancer.
    Endometroid . said hysterectomy plus all others has to be removed, cervix, lymph nodes, tubes, etc. He had cat, pet, chest xrays done, told me all is ok, no cancer throughout body.

    Was told, my knee is advanced arthritis, needs knee replacement down the road. QUESTION: does anyone know or have info , if the knee issues and pain has anything to do with the endonometroid (spell ?) cancer, or if this is just two different health issues that do not reflect one another?

    Surgery very near for hysterectomy, then few months later knee replacement considered, right now very limited walking, steps, use of cane and walker.

    any info would be great, thanks BAS,

  2. #2
    Moderator Top User jorola's Avatar
    Join Date
    May 2014
    Welcome to forum BAS. Sorry you had to look us up.
    Unless cancer was in your knee I would say your arthritic knee has nothing to do with the endometroid cancer. These are two different types of health conditions. However I am not a dr. The best person to ask is your oncologist.
    Please keep in touch and lets us know how you are doing, ok?
    All the best,
    Wife to husband with squamous lung cancer stage 3 b
    dx - April 20/14
    tx started May 20/14 - radiation and chemo
    June 23 - chemo finished
    July 4 - radiation finished
    July 8 - PET scan shows tumor almost gone, lymph nodes back to normal
    Married July 19/14
    Sept 9/14 - repeat can shows tumor continues to shrink more, no new spots. New coughing and pain due to chest infection or side effect of radiation.
    Sept 19/14 - not infection but pneumonitis, place on dex for 4 weeks
    Oct 22/14 - now off of dex and facing even more symptoms of withdrawal
    Dec 16/14 - pretty much nothing left but a scar
    April 7/15 - ditto scan and screw you stats
    Oct 6/15 - more scarring but still cancer still gone
    Feb 2016 -scan the same
    Aug 2016 - more of the same
    Aug 2017 - and ditto
    Aug 2018 - 4 yrs NED - no evidence of disease
    Aug 2019 - 5 yrs NED and discharged from cancer clinic!!!!!

  3. #3
    Newbie New User
    Join Date
    Jun 2019
    Thanks for reply.
    Just saw ortho. Gave me cortonozine shot. Walker use . i will get thru it all.

    Ok now getting ready for surgery not far away. Praying

    All this so sudden. Only leakage or spotting blood mucus.
    All so sudden. Told if surgey not done within 1 yr will spread thru body.
    I said ok surgery.
    Told I came in and caught this in time.
    Thanks for taking time to reply back to me.

  4. #4
    Super Moderator Top User po18guy's Avatar
    Join Date
    Feb 2012
    Sorry to hear this, but glad that you are doing OK, and with a good attitude. It is a long shot, but one possible link "might" be if the endometrial tumor cells were releasing cytokines which triggered your immune system to begin attacking your body. I know of one lymphoma which does this - but lymphoma is a completely different cancer of the immune system.
    05/08-07/08 Tumor appears behind left ear. Followed by serial medical incompetence on the parts of PCP, veteran oncologist and pathologist (misdiagnosis via non-diagnosis). Providential guidance to proper care at an NCI designated comprehensive cancer center.
    07/08 Age 56 DX 1) Peripheral T-Cell Lymphoma-Not Otherwise Specified. Stage IV-B, >50 ("innumerable") tumors, bone marrow involvement.
    08/08-12/08 Four cycles CHOEP14 + four cycles GND (Cyclofosfamide, Doxorubicin, Vincristine, Etoposide, Prednisone & Gemcitabine, Navelbine, Doxil)
    02/09 2) Relapse.
    03/09-06/13 Clinical trial of Romidepsin > long-term study. NED for 64 twenty-eight day cycles, dose tapered.
    07/13 3) Relapse, 4) Suspected Mutation.
    08/13-02/14 Romidepsin increased, stopped for lack of response. Watch & Wait.
    09/14 Relapse/Progression. Visible cervical nodes appear within 4 days of being checked clear.
    10/06/14 One cycle Belinostat. Discontinued to enter second clinical trial.
    10/25/14 Clinical trial of Alisertib/Failed - Progression.
    01/12/15 Belinostat resumed/Failed - Progression. 02/23/15
    02/24/15 Pralatrexate/Failed - Progression. 04/17/15
    04/15 Genomic profiling reveals mutation into PTCL-NOS + AngioImmunoblastic T-Cell Lymphoma. Stage IV-B a second time. Two dozen tumors + small intestine (Ileum) involvement.
    04/22/15 TEC (Bendamustine, Etoposide, Carboplatin). Full response in two cycles. PET/CT both clear. Third cycle followed.
    06/15-07/15 Transplant preparation (X-rays, spinal taps, BMB, blood test, MUGA scan, lung function, CMV screening, C-Diff testing etc. etc. etc.) Intrathecal Methotrexate during spinal tap.
    BMB reveals 5) 26% blast cells of 20q Deletion Myelodysplastic Syndrome MDS), a bone marrow cancer and precursor to Acute Myeloid Leukemia.
    07/11-12/15 Cyclofosfamide + Fludarabine conditioning regimen.
    07/16/15 Total Body Irradiation.
    07/17/15 Moderate intensity Haploidentical Allogeneic Stem Cell Transplant receiving my son's peripheral blood stem cells.
    07/21-22/15 Triple dose Cyclofosfamide + Mesna, followed by immunosuppressants Tacrolimus and Mycophenolate Mofetil.
    07/23-08/03/15 Marrow producing zero blood cells. Fever. Hospitalized two weeks.
    08/04/15 Engraftment occurs, and blood cells are measurable - released from hospital.
    08/13/15 Day 26 - Marrow is 100% donor cells. Platelets climbing steadily, red cells follow.
    09/21/15 Acute skin Graft versus Host Disease arrives.
    DEXA scan reveals Osteoporosis.
    09/26/-11/03/15 Prednisone to control skin GvHD.
    11/2015 Acute GvHD re-classified to Chronic Graft versus Host Disease.
    05/2016 Tacrolimus stopped. Prednisone from 30-90mg daily tried. Sirolimus begun. Narrow-band UV-B therapy started, but discontinued for lack of response. One treatment of P-UVAreceived, but halted due to medication reaction.
    09/16/16 Three skin punch biopsies.
    11/04/16 GvHD clinical trial of Ofatumumab (Arzerra) + Prednisone + Methylprednisolone begun.
    12/16 Type II Diabetes, Hypertension - both treatment-related.
    05/17 Extracorporeal Photopheresis (ECP) begun in attempt to control chronic Graft-versus-Host-Disease (cGvHD. 8 year old Power Port removed and replaced with Vortex (Smart) Port for ECP.
    05/2017 Chronic anemia (low hematocrit). Chronic kidney disease. Cataracts from radiation and steroids.
    06/17 Trying various antibiotics in a search for tolerable prophylaxis.
    08/17 Bone marrow biopsy reveals the presence of 2% cells with 20q Deletion Myelodysplastic Syndrome, considered to be Minimum Residual Disease.
    12/17 Bone marrow biopsy reveals no abnormalities in the marrow - MDS eradicated. The steroid taper continues.
    01/18 Consented for Kadmon clinical trial.
    03/18 Began 400mg daily of KD025, a rho-Associated Coiled-coil Kinase 2 Inhibitor (ROCK2).
    09/18 Due to refractory GvHD, Extracorporeal Photopheresis halted after 15 months ue to lack of additional benefit.
    10/18 I was withdrawn from the Kadmon KD025 clinical trial due to increasing fatigue/lack of benefit.
    11/18 Began therapy with Ruxolitinib (Jakafi), a JAK 1&2 inhibitor class drug. Started at half-dose due to concerns with drug interactions.
    11/19 MRI of brain reveals apparently benign frontal lobe tumor. Has the appearance of a cerebral cavernoma. Watch & wait on that.

    To date: 1 cancer, relapse, second relapse/mutation into 2 cancers, then 3 cancers simultaneously, 20 chemotherapy/GVHD drugs in 11 regimens (4 of them at least twice), 5 salvage regimens, 4 clinical trials, 5 post-transplant immuno-suppressant/modulatory drugs, the equivalent of 1,000 years of background radiation from 40+ CT series scans and about 24 PET scans.
    Both lymphoid and myeloid malignancies lend a certain symmetry to the hematological journey.

    Believing in the redemptive value of suffering makes all the difference.

  5. #5
    Hi BAS,

    I am wondering if you had hysterectomy and how you are faring? Curious as to what stage your pathology report reveals as well. I am praying for a full recovery for you. Take care!
    Diagnosed Sept. 2005
    Stage III-C Endometrial Adenocarcinoma
    Grade 2
    My Story:

  6. #6
    Newbie New User
    Join Date
    Dec 2019
    Hi everyone my mother in law just got diagnosed with uterine cancer. The doctor said it’s for sure a stage 3 but could be a stage 4. It’s in her entire pelvis and in her lymph nodes and her aorta lymph nodes. My main concern is he doesn’t want to do surgery and everything I read they have had surgery.

  7. #7
    Typically a hysterectomy is done, at least in regards to Stage III cancers of the uterus. From what you have written, if it has spread everywhere in her pelvis, it could well be stage IV. It is possible the cancer has invaded into her bladder or bowel. But even regarding women diagnosed with Stage 4 uterine cancers, hysterectomies are often performed --still she will require adjuvant treatment after such a surgery. It could be this doctor wants to do chemotherapy or radiation absent of surgery.

    If possible, obtain a second opinion. Be point blank to him, the doctor needs to be questioned as to why he believes a hysterectomy is not in order for her case. Regardless of the answer, try to get another opinion anyway. Doctors can certainly differ in their opinions concerning the treatment of their patients. A hysterectomy might help mitigate some of her symptoms, like heavy bleeding and pain. She needs to examine all viable options to treat the cancer.

    There are survivors of stage 4 uterine cancer out there, despite the odds. I hope you get the answers you are seeking and your mother-in-law will be in prayers.
    Diagnosed Sept. 2005
    Stage III-C Endometrial Adenocarcinoma
    Grade 2
    My Story:


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