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Thread: Article on link between ADT and risk of Alzheimers / dementia

  1. #1

    Article on link between ADT and risk of Alzheimers / dementia

    https://www.inquirer.com/news/prosta...-20190708.html

    Not good news. Sorry if this study has already been referenced in a post.
    Year of birth: 1951
    PSA summer 2014 4.2
    PSA fall 2014 4.4
    Biopsy fall 2014, Gleason 3+3
    Decided on RALP fall 2014
    RALP U of Penn, Thomas Guzzo Feb 2015, both nerve bundles spared.
    Pathology after surgery Gleason 3+4, 10% of Prostate, contained within prostate
    PSA May 2015 <0.1

  2. #2
    I posted this earlier and nobody seemed too concerned. I can tell you this, the media has had a field day with it since the study was first published. It definitely got my attention.

  3. #3
    Quote Originally Posted by three putt View Post
    I posted this earlier and nobody seemed too concerned. I can tell you this, the media has had a field day with it since the study was first published. It definitely got my attention.
    A thread on this topic was started by three put. In my last post there I linked to a NYT article as well as the paper that prompted the press interest.

    My first reaction is that this has to be taken into consideration, but the amount of increased risk for dementia has to be weighed against the possibly lifesaving benefits of ADT. If I really needed ADT, a 20% increase in my general risk of dementia might be acceptable. This unfortunate complication needs to be taken into account in developing new ADT medications.

    Djin
    Last edited by DjinTonic; 07-10-2019 at 02:13 AM.

  4. #4
    Senior User
    Join Date
    Jan 2019
    Posts
    479
    Quote Originally Posted by three putt View Post
    I posted this earlier and nobody seemed too concerned. I can tell you this, the media has had a field day with it since the study was first published. It definitely got my attention.
    More worried about death from cancer than dementia.
    DOB 5/1957

    PSA - 11/2010=1.9, 6/12=2.3, 12/13=2.19, 12/14=2.64, 3/17=5.29, 3/17=3.91, 6/17=3.47, 12/17=4.50, 12/17=3.80, free PSA low risk (local (Uro, “My opinion you don’t have cancer), 8/18=5.13, 10/18=5.1, 10/19 ISO PSA 56% risk cancer. All DREs negative.

    DX 12/18, GS 8, 4+4 6/12 cores, LL Apex 100%, LM Apex 60%, LL Mid 50%, LMM 40%, LL Base 5%, LM <5%, Right side negative, (Uro opinion “This has been going on for a year”.... ah, more like 2 years ). Bone scan/CT negative

    2/25/19 R-LESS (Robotic Laparoendoscopic Single Site Surgery) outpatient Cleveland Clinic,

    3/6/19. Pathology - Grade Group 4 with Intraductal Carinoma
    T3aNO, GS8, 21 mm unifocal tumor 10%. -7 Nodes, - SV, - Margins, - PNI,
    - bladder neck neg., +LVI, + EPE non focal apex/mid lateral 1mm max extension, Cribriform pattern present. Decipher .86 High Risk.

    PSA 3/27/19 .03. (29 days)
    4/25/19 <.03. (58 days)
    5/25/19 <.02. (88 days)

    ADT - 6/3/19
    ART - 8/5/19

  5. #5
    Experienced User BeeMan's Avatar
    Join Date
    May 2012
    Posts
    79
    I'm more worried about dementia than cancer.....I will be 73 in September.
    Born in 1946
    1st Biopsy 4/16/2002, Neg PSA 5.30
    Dx age 65: AS
    2012 Gleason 6 (3+3) L Apex <8% positive
    2nd Prostate biopsy T1c
    PSA 6.41
    3rd biopsy age 66: AS
    2013 Gleason 7(3 & 4)
    PSA: 6.85
    PSA: 9.29 2013
    4th Prostate biopsy 1/16/2014
    2 cores positive.
    L lateral base: Gleason of 7 (3+4)
    L Lateral Apex: Prostatic Adenecarcinoma Gleason 7 (4+3)
    HT started 02/24/2014: Casodex one month
    Eligard injection 03/02/2014 & 9/05/2014
    Bone Scan good
    MRI of prostate 8 mm nodular (lateral left peripheral zone near the mid gland)
    Prostatic capsule intact
    Periprostatic fat, semi vesicles, periprostatic neurovascular bundle clear
    T1c-T2c
    IMRT started 4/28/ 2014 (39 Rx) to June 23, 2014
    Hot flashes, fatigue, leg pain, insomnia, body aches, ED
    PSA < 0.02, testosterone 36 as of May 2015
    PSA 08/17/2016 0.44
    PSA 8/23/2017 0.59
    PSA 2/27/18 0.57
    PSA 12/05/2018 0.74 repeat every 6 months

  6. #6
    Top User garyi's Avatar
    Join Date
    Apr 2017
    Posts
    1,293
    I read the story, but can't remember a thing about it.
    72...LUTS for the past 7 years
    TURP 2/16,
    G3+4 discovered
    3T MRI 5/16
    MRI fusion guided biopsy 6/16
    14 cores; four G 3+3, one G3+4,
    CIPRO antibiotic = C. Diff infection 7/16
    Cured with Vanco for 14 days
    Second 3T MRI 1/17
    Worsened bulging of posterior capsule
    Oncotype DX GPS 3/17, LFP risk 63%, Likelihood of Low
    Grade Disease 81%, Likelihood of Organ Confined 80%
    RALP 7/13/17 Dr. Gonzaglo @ Univ of Miami
    G3+4 Confirmed, Organ confined
    pT2 pNO pMn/a Grade Group 2
    PSA 0.32 to .54 over 3 months
    DCFPyl PET & ercMRI Scans - 11/17
    A one inch tumor still in prostate bed = failed surgery
    All met scans clear
    SRT, 2ADT, IMGT 70.2 Gys @1.8 per, completed 5/18
    Radiation Procitis, and Ulcerative Colitis flaired after 20 years
    PSA <.006 9/18, .054 11/18, .070 12/18, .067 2/19, .078 5/19, .074 7/19
    We'll see....what is not known dwarfs what is thought to be fact

  7. #7
    There is also a correlation between heart disease and diabetes due to low testosterone. I don't have a study to link but it becomes relevant for those who have cancer and low testosterone.

 

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