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Thread: PanCan Concerns

  1. #1
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    PanCan Concerns

    I have concerns about PC, history of heavy alcohol abuse.

    In the Spring had a CT w/contrast and Pancreas was described as “unremarkable.” I do have a fatty liver.

    The concerning thing was I have a slightly elevated CEA, Lipase, LFTs including increased billirubin though I have a US and Hida and no blockages. CA 19-9 is < 10. Supposedly PC tumors can destroy RBC and this will raise billirubin levels. Have some slight left side pain.

    I am scheduled for some additional blood work and another US. Concern is maybe I am in very early stages of tumor growth and this is way it shows up on labs but not imaging yet.

  2. #2
    Super Moderator Top User ddessert's Avatar
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    I’ve moved your post to its own thread.

    Blood work does not diagnose pancreatic cancer. The CT scan you had in the spring is a great diagnostic tool as is an Endoscopic US (not an abdominal US) or MRI.

    With the history of alcohol use, many organs can be damaged. To me, bilirubin points towards the liver or gallbladder more than pancreas. But then, I’m not a doctor.
    BRCA2 3398del5
    Dec 2010 - back/abd pain
    May 2011 - Unresectable stage III, 2.5cm tumor
    Jun-Aug 2011 - Gem/Cis, 9 rounds
    Oct-Nov 2011 - IMRT+Xeloda
    Oct 2011-Sep 2012 - shrinking tumor
    Feb 2012 - National Familial Pancreatic Study
    Aug 2012 - Downgraded to stage IIA, PGP
    Sep 2012 - Whipple, T3N0M0, 0.5cm tumor, 0/16 lymph nodes
    Dec 2012 - Quebec PanCan Study
    Sep 2012-May 2019 - NED
    Mar 2013-present - NCT01088789
    Jun 2019- NCT03805919
    @pancanology

  3. #3
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    Thanks, yes, that’s what the doctors think. I requested an EUS but they won’t order it yet.

    True on labs, just doing some research PC patients commonly have elevated CEA and Lipase levels. So that part of concerning.

    They are focused on Liver now too and US may lead to a MRI if it shows anything. The doctor suggested that a CT w/contrast is probably the best means to detect masses and MRI best to determine risks with seeing small blood vessels that could be feeding tumors.

  4. #4
    Super Moderator Top User ddessert's Avatar
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    When you look at those PanCan patients with elevated CEA and lipase, you are usually looking at patients who are well along in the cancer, not early detection. Hardly anyone really uses CEA for pancreatic cancer, it’s usually CA19-9. About 5-20% (dependent on ethnicity) don’t make any CA19-9 so it’s also an inadequate indicator for diagnosis.
    BRCA2 3398del5
    Dec 2010 - back/abd pain
    May 2011 - Unresectable stage III, 2.5cm tumor
    Jun-Aug 2011 - Gem/Cis, 9 rounds
    Oct-Nov 2011 - IMRT+Xeloda
    Oct 2011-Sep 2012 - shrinking tumor
    Feb 2012 - National Familial Pancreatic Study
    Aug 2012 - Downgraded to stage IIA, PGP
    Sep 2012 - Whipple, T3N0M0, 0.5cm tumor, 0/16 lymph nodes
    Dec 2012 - Quebec PanCan Study
    Sep 2012-May 2019 - NED
    Mar 2013-present - NCT01088789
    Jun 2019- NCT03805919
    @pancanology

  5. #5
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    Quote Originally Posted by Gss2003 View Post
    I have concerns about PC, history of heavy alcohol abuse.

    In the Spring had a CT w/contrast and Pancreas was described as “unremarkable.” I do have a fatty liver.

    The concerning thing was I have a slightly elevated CEA, Lipase, LFTs including increased billirubin though I have a US and Hida and no blockages. CA 19-9 is < 10. Supposedly PC tumors can destroy RBC and this will raise billirubin levels. Have some slight left side pain.

    I am scheduled for some additional blood work and another US. Concern is maybe I am in very early stages of tumor growth and this is way it shows up on labs but not imaging yet.
    Gss2003, i sent you a private message. Please check

 

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