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Thread: Swollen Inguinal Lymph Nodes

  1. #1
    Newbie New User
    Join Date
    Sep 2019

    Swollen Inguinal Lymph Nodes

    About 2 months ago, i noticed a lump in the groin area/inguinal area, and obviously doctor google dove straight into the deep end with cancer. Now I didnt worry myself too much over it, but did consult my doctor. He then gave me an ultrasound for 4-6 weeks time if it hadnt gone away.
    So here I am today, just after my ultrasound, and now realizing that it isnt just one swollen lymph node, but a lot of swollen lymph nodes.

    Next doctor appointment is in 4 days time, and honestly just freaking myself out over what it could be.
    Its also been cutting off some blood circulation to my leg, due to some of the lymph nodes pressing onto veins, so its always tiring at the moment dealing with after walking. Some advice and thoughts could be great right now

  2. #2
    Senior User
    Join Date
    Mar 2017

    Sorry your concern has brought you to this forum. At this point, it is worthwhile remembering - and could be helpful in maintaining your sanity - that you do not yet have a cancer diagnosis, and there could be other explanations to your current lymphadenopathy.

    Depending on what the ultrasound report says regarding the size and structure of those swollen lymph nodes, your doctor may decide to refer you to a surgeon for an excisional biopsy. The pathology lab report will then indicate whether they have - or not - found any cancer cells, and provide more detail on the nature of that cancer. Four days is really not a long time to wait, and there is no reason to believe that anything will happen in the meantime, since you've had this for at least two months. So, take a few deep breaths and keep yourself busy until that appointment.

    Should you end up being diagnosed with cancer though, you will find the support and information you need here.

    Do keep us posted.

    Kind regards,

    06/2015 - Spontaneous pelvic fracture after 8 years of unexplained left hip pain
    02/2016 - 52 y.o. - Final Dx: Grade 2, Stage 4 Primary Bone Follicular lymphoma
    TTT - 6 R-CHOP21 (03-06/2016) + Maintenance Rituximab (08/2016-04/2018.)
    Currently in remission - Semestrial scans+mris & follow-up appointments with hematologist.

  3. #3
    Super Moderator Top User po18guy's Avatar
    Join Date
    Feb 2012
    We have a lot of nodes in our groins, and they tend to be somewhat larger than elsewhere, due to the potential for infections in that area. Although you cannot forget what you have read on Google, it sounds more like a localized infection of some type. A urinary tract infection, even if mild, can produce such enlarged/reactive nodes. And infections come in three types: viral bacterial and fungal. Antibiotics are effective against only bacterial infections, and even then against only a fairly narrow range of infections. So, if you receive antibiotics and nothing changes, that is still not cause for alarm.

    Consider: our bodies are capable of about 150 different symptoms. Yet, there are over 68,000 known illnesses and conditions. By simple math, that is 450+ potential illnesses per symptom. Since we com into contact with billions of pathogens daily (in our air, water and food), sooner or later the body must fight and enlarged lymph nodes are one sign of that Yet, enlarged nodes are a produce of your immune system responding to some sort of pathogen
    05/08-07/08 Tumor appears behind left ear. Followed by serial medical incompetence on the parts of PCP, veteran oncologist and pathologist (misdiagnosis via non-diagnosis). Providential guidance to proper care at an NCI designated comprehensive cancer center.
    07/08 Age 56 DX 1) Peripheral T-Cell Lymphoma-Not Otherwise Specified. Stage IV-B, >50 ("innumerable") tumors, bone marrow involvement.
    08/08-12/08 Four cycles CHOEP14 + four cycles GND (Cyclofosfamide, Doxorubicin, Vincristine, Etoposide, Prednisone & Gemcitabine, Navelbine, Doxil)
    02/09 2) Relapse.
    03/09-06/13 Clinical trial of Romidepsin > long-term study. NED for 64 twenty-eight day cycles, dose tapered.
    07/13 3) Relapse, 4) Suspected Mutation.
    08/13-02/14 Romidepsin increased, stopped for lack of response. Watch & Wait.
    09/14 Relapse/Progression. Visible cervical nodes appear within 4 days of being checked clear.
    10/06/14 One cycle Belinostat. Discontinued to enter second clinical trial.
    10/25/14 Clinical trial of Alisertib/Failed - Progression.
    01/12/15 Belinostat resumed/Failed - Progression. 02/23/15
    02/24/15 Pralatrexate/Failed - Progression. 04/17/15
    04/15 Genomic profiling reveals mutation into PTCL-NOS + AngioImmunoblastic T-Cell Lymphoma. Stage IV-B a second time. Two dozen tumors + small intestine (Ileum) involvement.
    04/22/15 TEC (Bendamustine, Etoposide, Carboplatin). Full response in two cycles. PET/CT both clear. Third cycle followed.
    06/15-07/15 Transplant preparation (X-rays, spinal taps, BMB, blood test, MUGA scan, lung function, CMV screening, C-Diff testing etc. etc. etc.) Intrathecal Methotrexate during spinal tap.
    BMB reveals 5) 26% blast cells of 20q Deletion Myelodysplastic Syndrome MDS), a bone marrow cancer and precursor to Acute Myeloid Leukemia.
    07/11-12/15 Cyclofosfamide + Fludarabine conditioning regimen.
    07/16/15 Total Body Irradiation.
    07/17/15 Moderate intensity Haploidentical Allogeneic Stem Cell Transplant receiving my son's peripheral blood stem cells.
    07/21-22/15 Triple dose Cyclofosfamide + Mesna, followed by immunosuppressants Tacrolimus and Mycophenolate Mofetil.
    07/23-08/03/15 Marrow producing zero blood cells. Fever. Hospitalized two weeks.
    08/04/15 Engraftment occurs, and blood cells are measurable - released from hospital.
    08/13/15 Day 26 - Marrow is 100% donor cells. Platelets climbing steadily, red cells follow.
    09/21/15 Acute skin Graft versus Host Disease arrives.
    DEXA scan reveals Osteoporosis.
    09/26/-11/03/15 Prednisone to control skin GvHD.
    11/2015 Acute GvHD re-classified to Chronic Graft versus Host Disease.
    05/2016 Tacrolimus stopped. Prednisone from 30-90mg daily tried. Sirolimus begun. Narrow-band UV-B therapy started, but discontinued for lack of response. One treatment of P-UVAreceived, but halted due to medication reaction.
    09/16/16 Three skin punch biopsies.
    11/04/16 GvHD clinical trial of Ofatumumab (Arzerra) + Prednisone + Methylprednisolone begun.
    12/16 Type II Diabetes, Hypertension - both treatment-related.
    05/17 Extracorporeal Photopheresis (ECP) begun in attempt to control chronic Graft-versus-Host-Disease (cGvHD. 8 year old Power Port removed and replaced with Vortex (Smart) Port for ECP.
    05/2017 Chronic anemia (low hematocrit). Chronic kidney disease. Cataracts from radiation and steroids.
    06/17 Trying various antibiotics in a search for tolerable prophylaxis.
    08/17 Bone marrow biopsy reveals the presence of 2% cells with 20q Deletion Myelodysplastic Syndrome, considered to be Minimum Residual Disease.
    12/17 Bone marrow biopsy reveals no abnormalities in the marrow - MDS eradicated. The steroid taper continues.
    01/18 Consented for Kadmon clinical trial.
    03/18 Began 400mg daily of KD025, a rho-Associated Coiled-coil Kinase 2 Inhibitor (ROCK2).
    09/18 Due to refractory GvHD, Extracorporeal Photopheresis halted after 15 months ue to lack of additional benefit.
    10/18 I was withdrawn from the Kadmon KD025 clinical trial due to increasing fatigue/lack of benefit.
    11/18 Began therapy with Ruxolitinib (Jakafi), a JAK 1&2 inhibitor class drug. Started at half-dose due to concerns with drug interactions.
    11/19 MRI of brain reveals apparently benign frontal lobe tumor. Has the appearance of a cerebral cavernoma. Watch & wait on that.

    To date: 1 cancer, relapse, second relapse/mutation into 2 cancers, then 3 cancers simultaneously, 20 chemotherapy/GVHD drugs in 11 regimens (4 of them at least twice), 5 salvage regimens, 4 clinical trials, 5 post-transplant immuno-suppressant/modulatory drugs, the equivalent of 1,000 years of background radiation from 40+ CT series scans and about 24 PET scans.
    Both lymphoid and myeloid malignancies lend a certain symmetry to the hematological journey.

    Believing in the redemptive value of suffering makes all the difference.


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