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Thread: Docetaxil increased bone pain

  1. #1
    Newbie New User
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    Nov 2019
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    Docetaxil increased bone pain

    My father began docetaxil chemotherapy last Wednesday. Was dealing with pain with fentanyl patch and Tylenol for low lumbar bone pain. Took him off Tylenol so it couldn’t hide potential fevers while on chemo. He was given an increased dose of fentanyl patch had it for two days now and is taking oxycodone for pain every four hours. His pain is now worse than ever. Has anyone experienced this? Elected to do chemotherapy to reduce tumor size to aid with pain. Were not warned of this.

  2. #2
    Moderator Top User HighlanderCFH's Avatar
    Join Date
    Nov 2011
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    7,281
    Welcome to the forum, Buckman,

    Sounds like your father is dealing with prostate cancer? Can you give us some details of his case? This will give us a better idea of his situation and will allow us to help you with more informed comments, etc.

    In the meantime, sorry to hear of his high pan levels. It sounds like the cancer is now in his bones? Knowing what he has been dealing with will enable us to be more helpful to you.

    Best of luck!
    Chuck
    July 2011 local PSA lab reading 6.41 (from 4.1 in 2009). Mayo Clinic PSA 9/ 2011 = 5.7.
    Local uro DRE revealed significant BPH, no lumps.
    PCa Dx Aug. 2011 age of 61.
    Biopsy DXd adenocarcinoma in 3/20 cores (one 5%, two 20%). T2C.
    Gleason 3+3=6. CT abdomen, bone scan negative.
    DaVinci prostatectomy 11/1/11 at Mayo Clinic (Rochester, MN), nerve sparing, age 62.
    Surgeon was Dr. Matthew Tollefson, who I highly recommend.
    Final pathology shows tumor confined to prostate.
    5 lymph nodes, seminal vesicules, extraprostatic soft tissue all negative.
    1.0 x 0.6 x 0.6 cm mass involving right posterior inferior, right posterior apex & left
    mid posterior prostate. Right posterior apex margin involved by tumor over 0.2 cm length,
    doctor says this is insignificant.
    Prostate 98 grams, tumor 2 grams.
    Catheter out in 7 days. No incontinence, minor dripping for a few weeks.
    Eight annual post-op exams 2012 through 2019: PSA <0.1
    Semi-firm erections without "training wheels," usable erections with 100mg Sildenafil.
    NOTE: ED caused by BPH, not the surgery.

  3. #3
    Hi Buckman & Welcome to The Forum! You will receive lots of support during this Journey - starting with our great moderator Chuck!

    Very sorry to read that your father appears to be at an advanced stage of PCa. This is undoubtedly very stressful for both your father and all of those close to him.

    Re Docetaxel: This chemotherapy agent was introduced to the fight against advanced/advancing PCa about 10 years ago. It has been a game changer in certain scenarios. It is reported to be fairly well tolerated so it is not likely causing additional pain. FYI, here is a link to some basic info on Docetaxel:

    https://www.pcf.org/about-prostate-c...-side-effects/

    If willing and when convenient, please share some additional information that you can put into a Signature. Instructions are at the top of The Forum page or link to:

    https://www.cancerforums.net/threads...ch-of-My-Posts

    The essential items to include are:

    - Age at diagnosis
    - PSA at time of Biopsy
    - Did he undergo Surgery, Radiation or both
    - Date of treatment (month & year)
    - If surgery, What were the Path Report findings: Gleason Grade / Lymph Nodes / Seminal Vesicles / Margins / Extraprostatic Extensions
    - PSA history following treatment(s)
    - How long has he been on Hormone Therapy (HT) / Androgen Deprivation Therapy (ADT)?
    - How many metastatic sites have been identified?

    What are his MDs saying about his status?

    Also, where is he being treated? There may be other Forum Brothers (FBs) who have also been treated there.

    Pain management is essential. Hoping that this phase of pain will clear up. Is he able to maintain basic physical activities: get out of bed, walk, ride in the car?

    Keep us updated. Looking forward to some improving news.

    MF
    PSA: Oct '09 = 1.91, Oct '11 = 2.79, Dec '11 = 2.98 (PSA, Free = 0.39ng/ml, % PSA Free = 13%)
    Referred to URO MD
    Jan '12: DRE = Positive: "Left induration"
    Jan '12: Biopsy = 6 of 12 Cores were Positive: 1 = G7 (3+4) and 5 = Gleason 6
    Referred to URO Surgeon
    March '12: Robotic RP: Left: PM + EPE. MD waited in surgery for preliminary Path Report then excised substantial left adjacent tissue(s) down to negative margins and placed 2 Ti clips for SR guidance, if needed in future.
    Pathology: Gleason (3+4) pT3a pNO pMX pRO c tertiary pattern 5 / Prostate Size = 32 grams / Tumor = Bilateral: 20% / PNI: present
    3 month Post Op standard PSA = <0.1 ng/ml
    1st uPSA at 7 months Post Op = 0.018 ng/ml
    uPSA remains "stable" at 91 Months Post Op: Mean = 0.022 (22x uPSAs: Range 0.017 - 0.032) LabCorp: Ultrasensitive PSA: Roche ECLIA
    Continence = Very Good (≥ 99%)
    ED = present

 

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