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Thread: do you know about mushroom Extract Maitake D-fraction?

  1. #1

    do you know about mushroom Extract Maitake D-fraction?

    I was told by a friend to take Maitake D-fraction extract, which apparently fights against cancer cells and boost your immune system. I have been reading a lot about that mushroom extract and it sounds like a miracle cure. So, i bought it and started taking it a few days ago. But my husband says that i should check with my oncologist before doing so, as we don't know if there is any interference with Arimidex. Does anyone know about Maitake D-fraction and does it have any interactions? Thanks. Nicole

  2. #2
    Hi Nicole. I 100% agree with your husband. ALWAYS consult with your own medical team before starting any supplement or alternative therapy. There is a risk of a supplement preventing your chemo from doing its work.

    Another comment: If it sounds too good, like a "miracle cure" it probably is not. I do not even believe in a cancer being curable. It has been nearly 16 years since I was first diagnosed (Nov 1992). But it recurred almost 13 years later (June 2005). I use the term No Evidence of Disease (NED) instead of CURE (Complete and Utterly Ridiculous Expression ).

    I am sorry about your cancer. You mind if I ask you what type of cancer you have?

    You are in my thoughts and prayers.
    Long-term cancer survivor
    1992 Astrocytoma grade 2, left motor strip
    2005 Recurrence this time said to be an Oligodendroglioma grade 3, same location.
    My Story Part 1: http://cancerforums.net/viewtopic.php?t=2528
    My Story Part 2: http://cancerforums.net/viewtopic.php?p=7350
    My Story Part 3: http://cancerforums.net/viewtopic.php?t=8029

  3. #3
    Administrator Top User ChemoMan's Avatar
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    Jun 2008
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    Hi Nicole

    The American cancer Society has a page on this, you can find it here :


    It is being tested at the moment, and its effects on Chemotherapy is unknown, so I would suggest not taking it during treatment and waiting till after chemo has finished, until such times as it is pronounced safe. If this stuff costs a fortune I wouldn't bother and I would stick to the stuff that really works.
    Age 62
    Diffuse Large B cell Lymphoma
    Stage 2a Bulky presentation
    Finished six cycles of R chop 21 26th May 2008
    Officially in remission 9th July 2008
    Remission reconfirmed 1st October 2008
    Remission reconfirmed 17th June 2009
    Remission reconfirmed 7th June 2010
    Remission reconfirmed 6th July 2011

    NED AND DECLARED CURED on the 2/01/2013

    No more scheduled visits to the Prof

    Still alive in 2019 !

    RULE NUMBER 1.....Don't Panic
    RULE NUMBER 2..... Don't forget rule Number 1

    Great moments often catch us unaware-beautifully wrapped in what others may consider a small one.

    I may not have gone where I intended to go,
    but I think I have ended up where I needed to be.

  4. #4
    I know this is an old post, but anyway...

    Maitake mushrooms are widely eaten food. There's doesn't appear to be any problems with using Maitake D-fraction. If anything, you'll probably only have upside with it, since it's one of the more widely used and tested of the medical mushrooms and it's not new.

    Many doctors are prescribing Maitake D-Fraction in Japan together with chemotherapy, especially for breast cancer, but also other cancers. In many cases it works synergistically so it enhances the effects of chemo and it protects the immune system by increasing NK cells and T cells which is what chemo will impact. Another one that is widely prescribed in hospitals in Japan is AHCC.

    Our doctor usually prescribes 400-600 mg Maitake D-Fraction. Choose a high-potency Pro product for cancer, rather than the standard grade stuff. I guess sometimes you have to pay more for quality and potency. Too low a dose may not produce results. So far no problems taking 600mg of this for the last 2 months. NK cells increased from 29% to 41%, and T cell number increased from 491 to 1080 ul.

    {links deleted by admin. http://cancerforums.net/viewtopic.php?t=12696 }

    All the best.

  5. #5

    Maitake use with chemotherapy

    As far as I know, there have not been any negative effects on maitake use on the effectiveness of any type of Chemo.

    And in recent studies, the combintation of Maitake MD fraction and chemo together, was much more effective against cancer than Only Chemo or Only MD fraction. And no treatment was the worst.

    Other than just activating the immune system, Md fraction has recently shown antimetastatic abilities and bone marrow cell stimulation.

    So go for it! And as the other people suggested, advise your doctor of any treatments you have chosen to take.

    And never give up on being 100% healthy.

  6. #6

    Maitake D-fraction extract

    I have not heard of any harmful side effects of this. However, I do not see this being recommended by many genuine alternative health experts. Probably better than nothing.

  7. #7
    Experienced User
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    Oct 2009

    Maitake D-fraction extact

    Although I completely trust my doctor's recommendations regarding alternative protocols I still like to do research on the supplements etc. that he suggests would be of benefit so that I have a better understanding of what effect they will have. Mushroom extracts have been a part of the daily supplement protocol I have followed since my diagnosis in early 2004.

    There are many clinical trial reports available through such reliable sources as PubMed which clearly state that not only do many mushroom extracts (Maitake included) strengthen and optimize the capacity of the immune system, they also enhance the effectiveness of chemotherapy.

    "Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity.1,2 In this non-random case series, a combination of MD-fraction and whole maitake powder was investigated to determine its effectiveness for 22- to 57-year-old cancer patients in stages II-IV. Cancer regression or significant symptom improvement was observed in 58.3 percent of liver cancer patients, 68.8 percent of breast cancer patients, and 62.5 percent of lung cancer patients. The trial found a less than 10-20 percent improvement for leukemia, stomach cancer, and brain cancer patients. Furthermore, when maitake was taken in addition to chemotherapy, immune-competent cell activities were enhanced 1.2-1.4 times, compared with chemotherapy alone. Animal studies have supported the use of maitake MD-fraction for cancer."

    SOURCES : http://www.ncbi.nlm.nih.gov/pubmed/12126464

    8 pages of reports discussing various cancers

  8. #8
    Regular User
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    May 2011

    More than meets the eye

    I wanted to comment on this discussion since I have a lot of inside information on this topic.

    First I want to make clear that there is a big misunderstanding in terminology surrounding this topic. And it has to do with the words D fraction or MD fraction.

    These words were originally created by Dr. Nanba of Kobe pharmaceutical university to name the series of fractions he purified from his extraction of the Maitake mushroom. Using column chromatography, he labeled different fractions of compounds A fraction, B fraction, C fraction, D fraction, etc.
    And found that the purified, high molecular weight 1,6 beta glucans with 1,3 branches in this fraction (labeled D = the fourth fraction taken off the chromatography column)) had significant activity for stimulating immunocompetent cells.

    He and his group of researchers have been publishing for over 15 years in Japan using these words to describe their patent protected extract. And ther research results are fantastic.

    However these same terms "D fraction" and "MD fraction" have been trademarked by an American company in America, who also sells their own type of Maitake extracts.

    So, it appears that 15 years of research in Japan and clinical trials at sloan kettering all are done on the commercial "D fraction" term patented in America. But that is not the case.

    Please understand that the word "D fraction" published in most scientific papers is absolutely not the same as the "D fraction" being sold to you at your health food store.

    The "D fraction" that is made by Dr. Nanba and his research team is a patented extract that has been further purified by chromatography methods to produce a super concentrated family of high molecualar weight compounds. It cannot be bought in the market place anywhere in the world because it is only an experimental scientific compound and no company currently makes this to sell.

    To emphasize "you cannot actually buy the real D fraction published by Dr. Nanba anywhere in the world. It's not for sale. It does not exist on the market".

    So issues about optimal dosage concentration and the dosages published in scientific papers do not correspond with any available Maitake extracts on the market.

    I don't want to be a downer on this forum. Because actually I am a huge believer in the immune enhancing effects of Maitake extracts.

    But I just wanted to shed some light on this subject, since I am one of the only people who have had access to this information.

    PS. in America, Dr. Nanba's real patented Maitake extracts can be confirmed by the patent number 5,854,404. That is his patented Maitake extract.

    Hope this helps to clarify the very blury naming and terminology surrounding this issue.

  9. #9
    Top User pbj11's Avatar
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    May 2007
    Question. I found this on the label of a Maitake mushroom extract that I was considering ordering to boost my daughter's immune system. What is your take on the quality and recommended dosage?

    Maitake Mushroom450 mg * (Grifola frondosa) (plant)
    Maitake Standardized PlantExtract 30 mg * (D-fraction 10% concentration)

    Other Ingredients: Cellulose (Plant Origin), Gelatin, Vegetable Stearic Acid, Silica. Guarantee: We use only the finest quality herbs and spices. Each is screened and finely milled for quick release. Preservative-free gelatin capsules contain pure milled herb powder. Natural Whole Herb products utilize ground plant parts to provide the natural components in the amounts found in nature.

    No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish, Sodium Free.
    Husband diagnosed with NSCLC Stage IV in 3/2005. Fought & lived over 2 1/2 years with multiple lines of treatment.

    Post describing our journey: http://cancerforums.net/viewtopic.ph...er=asc&start=0

    Left my embrace to live with our Heavenly Father in October of 2007 and now breathes with ease forever. I will miss this gentle, giving soul with the easy smile for the rest of my days, but have faith we will be together again. He's just getting a little break from me!

  10. #10
    Regular User
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    May 2011
    Hi pbj11. That product mostly looks like a holistic type, since it contains alot of whole maitake mushroom. That is good, if you don't have access to fresh Maitake in your area.
    For the extract it looks like one serving contains 10% of 30 mg. So 3mg of total extract (if my math is right). Please somebody correct me if I'm wrong.
    This is not a very large dose of extract. But would probably be suitable for daily use for someone who is already healthy. Similar to putting a handfull mushrooms in your recipe for dinner.
    So there IS benefit to be had from eating them.


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